Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk
Abstract: Polyunsaturated fatty acids (PUFAs) may have effects on hemostasis, although the results are controversial. Sex could modulate PUFAs metabolism with differential effects on cardiovascular risk (CVR). The aim was to analyze the association between food source (FS) intake of omega...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/34872 |
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I10-R327-article-34872 |
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| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
polyunsaturated fatty acids fibrinogen cardiovascular diseases acidos grasos poliinsaturados fibrinógeno enfermedades cardiovasculares |
| spellingShingle |
polyunsaturated fatty acids fibrinogen cardiovascular diseases acidos grasos poliinsaturados fibrinógeno enfermedades cardiovasculares Leconte , A Otero Ramonda , E Peranovich , E Defagó , MD Oberto , MG Marchiori , GN Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| topic_facet |
polyunsaturated fatty acids fibrinogen cardiovascular diseases acidos grasos poliinsaturados fibrinógeno enfermedades cardiovasculares |
| author |
Leconte , A Otero Ramonda , E Peranovich , E Defagó , MD Oberto , MG Marchiori , GN |
| author_facet |
Leconte , A Otero Ramonda , E Peranovich , E Defagó , MD Oberto , MG Marchiori , GN |
| author_sort |
Leconte , A |
| title |
Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| title_short |
Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| title_full |
Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| title_fullStr |
Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| title_full_unstemmed |
Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| title_sort |
food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk |
| description |
Abstract:
Polyunsaturated fatty acids (PUFAs) may have effects on hemostasis, although the results are controversial. Sex could modulate PUFAs metabolism with differential effects on cardiovascular risk (CVR).
The aim was to analyze the association between food source (FS) intake of omega 3 and omega 6 (n-3 and n-6) PUFAs serum profile and plasma fibrinogen levels, as a prothrombotic marker in patients with CVR according to sex.
Observational, correlational and cross-sectional study. Participated 249 adults, both sexes, over 40 years old, with CVR according to waist circumference, cardiology service assistants of the National Hospital of Clinic (NHC), Cordoba, 2017- 2020. Ethical aspects were approved by Institutional Ethics Committee of the Health Research - NHC. The information was collected by using a clinic history, and validated food frequency and tobacco questionnaires. Anthropometric measurements, blood pressure, lipid profile, glycemia and fibrinogen concentrations were taken by standard norms. Interfood v.1.3 software was employed to process dietary information. Fisher’s or Wilcoxon’s tests were used to analyze variables by group. Spearman’s test was used to determine the association between consumption of FS, PUFAs n-3 and n-6 profile and plasma fibrinogen (p=<0.05).
Significant differences were observed in lipid profile, glycemia and fibrinogen, being higher in women than men (p=<0.01, 0.05 y 0.05, respectively). Intake of soybeans and derivatives, FS of PUFAs n-3 and red meat, FS of PUFAs n-6 were statistically different according to sex (p=0.008 y 0.002, respectively). Men showed a significantly higher intake of PUFAs n-3 y n-6 (p=<0.05). We found a positive correlation between arachidonic fatty acid (20:4 n-6) intake and plasma fibrinogen levels, only in male (r=0,44 y p=0.02). There were no associations between PUFAs n-3 and fibrinogen.
In conclusion, 20:4 n-6 could increase plasma fibrinogen levels in male, and this is associated with the production of pro-inflammatory eicosanoids from foods source intake of PUFAs n-6. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34872 |
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I10-R327-article-348722024-04-15T16:19:09Z Food source intake of polyunsaturated fatty acids and the relation to with plasma fibrinogen in patients with cardiovascular risk Consumo de alimentos fuente de ácidos grasos poliinsaturados y su relación con el fibrinógeno plasmático en pacientes con riesgo cardiovascular Leconte , A Otero Ramonda , E Peranovich , E Defagó , MD Oberto , MG Marchiori , GN polyunsaturated fatty acids fibrinogen cardiovascular diseases acidos grasos poliinsaturados fibrinógeno enfermedades cardiovasculares Abstract: Polyunsaturated fatty acids (PUFAs) may have effects on hemostasis, although the results are controversial. Sex could modulate PUFAs metabolism with differential effects on cardiovascular risk (CVR). The aim was to analyze the association between food source (FS) intake of omega 3 and omega 6 (n-3 and n-6) PUFAs serum profile and plasma fibrinogen levels, as a prothrombotic marker in patients with CVR according to sex. Observational, correlational and cross-sectional study. Participated 249 adults, both sexes, over 40 years old, with CVR according to waist circumference, cardiology service assistants of the National Hospital of Clinic (NHC), Cordoba, 2017- 2020. Ethical aspects were approved by Institutional Ethics Committee of the Health Research - NHC. The information was collected by using a clinic history, and validated food frequency and tobacco questionnaires. Anthropometric measurements, blood pressure, lipid profile, glycemia and fibrinogen concentrations were taken by standard norms. Interfood v.1.3 software was employed to process dietary information. Fisher’s or Wilcoxon’s tests were used to analyze variables by group. Spearman’s test was used to determine the association between consumption of FS, PUFAs n-3 and n-6 profile and plasma fibrinogen (p=<0.05). Significant differences were observed in lipid profile, glycemia and fibrinogen, being higher in women than men (p=<0.01, 0.05 y 0.05, respectively). Intake of soybeans and derivatives, FS of PUFAs n-3 and red meat, FS of PUFAs n-6 were statistically different according to sex (p=0.008 y 0.002, respectively). Men showed a significantly higher intake of PUFAs n-3 y n-6 (p=<0.05). We found a positive correlation between arachidonic fatty acid (20:4 n-6) intake and plasma fibrinogen levels, only in male (r=0,44 y p=0.02). There were no associations between PUFAs n-3 and fibrinogen. In conclusion, 20:4 n-6 could increase plasma fibrinogen levels in male, and this is associated with the production of pro-inflammatory eicosanoids from foods source intake of PUFAs n-6. Resumen: Los ácidos grasos poliinsaturados (AGPI) han demostrado efectos sobre la hemostasia vascular, aunque a la fecha los resultados son controvertidos. El sexo podría modular el metabolismo de los AGPI con efectos diferenciales sobre el riesgo cardiovascular (RCV). Se propuso analizar la asociación entre el consumo de alimentos fuente (AF) y perfil cuali-cuantitativo de AGPI omega 3 y 6 (n-3 y n-6) y los niveles plasmáticos de fibrinógeno, como marcador protrombótico en pacientes RCV según sexo. Estudio observacional, correlacional y de corte transversal. Participaron 249 adultos de ambos sexos, mayores de 40 años con RCV según circunferencia de cintura, asistentes al servicio de Cardiología del Hospital Nacional de Clínicas (HNC), Córdoba, durante el periodo 2017-2020. Los aspectos éticos fueron aprobados por el Comité Institucional de Ética de las Investigaciones en Salud del HNC. La información se recolectó a través de la historia clínica, los cuestionarios de frecuencia de consumo alimentario y de tabaco. Se tomaron medidas antropométricas, presión arterial, perfil lipídico, glucemia y concentraciones de fibrinógeno. La información alimentaria-nutricional fue procesada con el software Interfood v.1.3. Se aplicaron los test de Fisher o Wilcoxon para comparar las variables según sexo y el test de correlación de Spearman para analizar la asociación entre el consumo de AF y perfil de AGPI n-3 y n-6, y las concentraciones de fibrinógeno (p=<0,05). Se observaron diferencias significativas en el perfil lipídico, glucemia y fibrinógeno, siendo mayor en las mujeres (p=<0,01, 0,05 y 0,05, respectivamente). El consumo de soja y derivados AF de AGPI n-3 y carnes rojas AF de AGPI n-6 fueron estadísticamente diferente según sexo (p=0,008 y 0,002, respectivamente). Los hombres presentaron una ingesta significativamente mayor de AGPI n-3 y n-6 (p=<0,05). Se halló una correlación positiva entre el consumo del ácido araquidónico (20:4 n-6) y el fibrinógeno solo en el sexo masculino (r=0,44 y p=0,02). No se observaron asociaciones entre los AGPI n-3 y el fibrinógeno. Se concluye que el 20:4 n-6 podría aumentar las concentraciones de fibrinógeno plasmático en los hombres, hecho que estaría asociado a la producción de eicosanoides proinflamatorios a partir del consumo de AF de AGPI n-6. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/34872 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |