Acquired hemophilia: Report of four cases
Introduction: Acquired hemophilia is a hemostasis disorder that occurs due to the presence of inhibitory autoantibodies that are directed against coagulation factor VIII. Clinically, it is manifested by spontaneous bleeding mainly in the skin and soft tissues, and unlike hereditary hemophilia ,the p...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/34045 |
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I10-R327-article-34045 |
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Universidad Nacional de Córdoba |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
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Artículo revista |
| topic |
hemophilia a factor viii autoantibodies hematoma Hematology Coagulation hemofilia a factor viii autoanticuerpos hematoma Hematología Coagulación hemofilia a fator viii autoanticorpos hematoma Hematología Coagulação |
| spellingShingle |
hemophilia a factor viii autoantibodies hematoma Hematology Coagulation hemofilia a factor viii autoanticuerpos hematoma Hematología Coagulación hemofilia a fator viii autoanticorpos hematoma Hematología Coagulação Milanesio, Martín Tabares, Aldo Hugo Caeiro, Gastón Andrés Olmedo, Julieta Montivero, Ana Romina Acquired hemophilia: Report of four cases |
| topic_facet |
hemophilia a factor viii autoantibodies hematoma Hematology Coagulation hemofilia a factor viii autoanticuerpos hematoma Hematología Coagulación hemofilia a fator viii autoanticorpos hematoma Hematología Coagulação |
| author |
Milanesio, Martín Tabares, Aldo Hugo Caeiro, Gastón Andrés Olmedo, Julieta Montivero, Ana Romina |
| author_facet |
Milanesio, Martín Tabares, Aldo Hugo Caeiro, Gastón Andrés Olmedo, Julieta Montivero, Ana Romina |
| author_sort |
Milanesio, Martín |
| title |
Acquired hemophilia: Report of four cases |
| title_short |
Acquired hemophilia: Report of four cases |
| title_full |
Acquired hemophilia: Report of four cases |
| title_fullStr |
Acquired hemophilia: Report of four cases |
| title_full_unstemmed |
Acquired hemophilia: Report of four cases |
| title_sort |
acquired hemophilia: report of four cases |
| description |
Introduction: Acquired hemophilia is a hemostasis disorder that occurs due to the presence of inhibitory autoantibodies that are directed against coagulation factor VIII. Clinically, it is manifested by spontaneous bleeding mainly in the skin and soft tissues, and unlike hereditary hemophilia ,the presence of hemarthrosis is infrequent. Although many cases are idiopathic, secondary causes must be sought since their treatment is key in the prognosis of the disease. Among these, the presence of autoimmune diseases, neoplasms, drugs, pregnancy, and postpartum stand out. Treatment is based on hemostatic measures to control the bleeding, and therapies to erradicate the autoantibody.
Methodology: In the following manuscript we describe four patients with acquired hemophilia its etiology, treatment, and prognosis.
Results: All four patients had resolution of the bleeding after specific treatment.
Conclusion: Acquired hemophilia is a rare disorder of hemostasis that should be suspected in patients with extensive spontaneous hematomas without prior coagulopathy. Although in many cases an underlying etiology is not found, secondary causes must be sought since their treatment is key to the patient's evolution. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34045 |
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I10-R327-article-340452022-06-06T11:18:17Z Acquired hemophilia: Report of four cases Hemofilia adquirida: Reporte de cuatro casos Hemofilia adquirida: Relatório de quatro casos Milanesio, Martín Tabares, Aldo Hugo Caeiro, Gastón Andrés Olmedo, Julieta Montivero, Ana Romina hemophilia a factor viii autoantibodies hematoma Hematology Coagulation hemofilia a factor viii autoanticuerpos hematoma Hematología Coagulación hemofilia a fator viii autoanticorpos hematoma Hematología Coagulação Introduction: Acquired hemophilia is a hemostasis disorder that occurs due to the presence of inhibitory autoantibodies that are directed against coagulation factor VIII. Clinically, it is manifested by spontaneous bleeding mainly in the skin and soft tissues, and unlike hereditary hemophilia ,the presence of hemarthrosis is infrequent. Although many cases are idiopathic, secondary causes must be sought since their treatment is key in the prognosis of the disease. Among these, the presence of autoimmune diseases, neoplasms, drugs, pregnancy, and postpartum stand out. Treatment is based on hemostatic measures to control the bleeding, and therapies to erradicate the autoantibody. Methodology: In the following manuscript we describe four patients with acquired hemophilia its etiology, treatment, and prognosis. Results: All four patients had resolution of the bleeding after specific treatment. Conclusion: Acquired hemophilia is a rare disorder of hemostasis that should be suspected in patients with extensive spontaneous hematomas without prior coagulopathy. Although in many cases an underlying etiology is not found, secondary causes must be sought since their treatment is key to the patient's evolution. Introducción: La hemofilia adquirida es un trastorno de la hemostasia que se produce por la presencia de autoanticuerpos inhibidores dirigidos contra el factor VIII de la coagulación. Clínicamente se manifiesta por sangrados espontáneos principalmente en piel y tejidos blandos, y a diferencia de la hemofilia hereditaria, la presencia de hemartrosis es infrecuente. Si bien muchos casos son idiopáticos, se deben buscar causas secundarias ya que el tratamiento de las mismas es clave en el pronóstico de la enfermedad. Dentro de estas destacan la presencia de neoplasias, enfermedades autoinmunes, fármacos, embarazo y postparto. El tratamiento se basa en medidas hemostáticas y terapias que permitan erradicar el autoanticuerpo. Metodología: En el siguiente manuscrito describimos cuatro pacientes con hemofilia adquirida con diferentes etiologías, tratamientos y pronóstico. Resultados: Los cuatro pacientes presentaron resolución del sangrado tras el tratamiento específico. Conclusión: La hemofilia adquirida es un trastorno raro de la hemostasia que debe sospecharse en pacientes con hematomas extensos espontáneos sin coagulopatía previa. Si bien en muchos casos no se encuentra una etiología subyacente, deben buscarse causas secundarias ya que el tratamiento de las mismas es clave para la evolución del paciente. Introdução: A hemofilia adquirida é um distúrbio da hemostasia causado pela presença de autoanticorpos inibitórios dirigidos contra o fator VIII de coagulação. Clinicamente, manifesta-se por sangramento espontâneo principalmente na pele e tecidos moles e, ao contrário da hemofilia hereditária, a presença de hemartrose é incomum. Embora muitos casos sejam idiopáticos, as causas secundárias devem ser buscadas, pois seu tratamento é fundamental no prognóstico da doença. Dentre estes, destacam-se a presença de neoplasias, doenças autoimunes, medicamentos, gravidez e puerpério. O tratamento é baseado em medidas hemostáticas e terapias que permitem a erradicação do autoanticorpo. Metodologia: No manuscrito a seguir, descrevemos quatro pacientes com hemofilia adquirida com diferentes etiologias, tratamentos e prognósticos. Resultados: Todos os quatro pacientes tiveram resolução do sangramento após tratamento específico. Conclusão: A hemofilia adquirida é um distúrbio raro de hemostasia que deve ser suspeitado em pacientes com hematomas espontâneos extensos sem coagulopatia prévia. Embora em muitos casos não seja encontrada uma etiologia subjacente, as causas secundárias devem ser buscadas, pois seu tratamento é fundamental para a evolução do paciente. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-03-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text texto texto application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/34045 10.31053/1853.0605.v79.n1.34045 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 1 (2022); 57-60 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 1 (2022); 57-60 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 1 (2022); 57-60 1853-0605 0014-6722 10.31053/1853.0605.v79.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/34045/37254 https://revistas.unc.edu.ar/index.php/med/article/view/34045/37065 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |