Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment

Introduction: Antipsychotics agents increase morbidity and mortality due to their metabolic impact. Information on its prescription and follow-up is scarce. The objective of this study was to estimate the chronic antipsychotic prescription prevalence and to evaluate the metabolic monitoring of patie...

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Autores principales: Vivacqua, María Noelia, Abudarham, Tomás, Pagotto, Vanina, Faccioli, José Luis
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:
antipsychotic agents
prevalence
aged
monitoring
antipsicóticos
prevalencia
ancianos
monitoreo
prevalência
idosos
monitoramento
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/32653
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic antipsychotic agents
prevalence
aged
monitoring
antipsicóticos
prevalencia
ancianos
monitoreo
antipsicóticos
prevalência
idosos
monitoramento
spellingShingle antipsychotic agents
prevalence
aged
monitoring
antipsicóticos
prevalencia
ancianos
monitoreo
antipsicóticos
prevalência
idosos
monitoramento
Vivacqua, María Noelia
Abudarham, Tomás
Pagotto, Vanina
Faccioli, José Luis
Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
topic_facet antipsychotic agents
prevalence
aged
monitoring
antipsicóticos
prevalencia
ancianos
monitoreo
antipsicóticos
prevalência
idosos
monitoramento
author Vivacqua, María Noelia
Abudarham, Tomás
Pagotto, Vanina
Faccioli, José Luis
author_facet Vivacqua, María Noelia
Abudarham, Tomás
Pagotto, Vanina
Faccioli, José Luis
author_sort Vivacqua, María Noelia
title Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
title_short Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
title_full Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
title_fullStr Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
title_full_unstemmed Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
title_sort antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment
description Introduction: Antipsychotics agents increase morbidity and mortality due to their metabolic impact. Information on its prescription and follow-up is scarce. The objective of this study was to estimate the chronic antipsychotic prescription prevalence and to evaluate the metabolic monitoring of patients treated with these medications.  Methods: We examined a retrospective cohort of patients older than 18 years treated in the outpatient setting of a hospital in Argentina. The crude and adjusted prevalence of chronic antipsychotic prescription was estimated by indirect standardization of the World Health Organization population, with its confidence interval (95%). It was evaluated whether the patients had biochemical determinations, systolic blood pressure (SBP), and body mass index (BMI) at the beginning and at 12 months of their treatment. Results: The crude antipsychotic prescription prevalence was 23.8 ‰ (95% CI 23.0 - 24.6) and the adjusted prevalence was 10.1 ‰ (95% CI 9.5-10.7). 3702 patients were evaluated. The male:female ratio was 0.6. Median age 77.5 years (IQR 25-75: 59.5-86.1). Quetiapine was the most frequently prescribed. Initial determinations: Lipid profile 1804 (48.7%), blood glucose 2034 (54.9%), SBP 2546 (68.8%) and BMI 1584 (42.8%). At 12 months: Lipid profile 680 (18.4%), blood glucose 898 (24.3%), SAT 1609 (43.5%), and BMI 1584 (21.7%).  Conclusions: We observed a higher prevalence of atypical antipsychotic prescription in the elderly and female population and scarce registry of biochemical determinations for adverse effects follow-up.   
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2021
url https://revistas.unc.edu.ar/index.php/med/article/view/32653
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spelling I10-R327-article-326532021-11-18T12:43:09Z Antipsychotic prescription prevalence and metabolic monitoring of patients under chronic treatment Prevalencia en la prescripción de antipsicóticos y monitoreo metabólico en pacientes bajo tratamiento crónico Prevalência na prescrição de antipsicóticos e monitoramento metabólico em pacientes em tratamento crônico Vivacqua, María Noelia Abudarham, Tomás Pagotto, Vanina Faccioli, José Luis antipsychotic agents prevalence aged monitoring antipsicóticos prevalencia ancianos monitoreo antipsicóticos prevalência idosos monitoramento Introduction: Antipsychotics agents increase morbidity and mortality due to their metabolic impact. Information on its prescription and follow-up is scarce. The objective of this study was to estimate the chronic antipsychotic prescription prevalence and to evaluate the metabolic monitoring of patients treated with these medications.  Methods: We examined a retrospective cohort of patients older than 18 years treated in the outpatient setting of a hospital in Argentina. The crude and adjusted prevalence of chronic antipsychotic prescription was estimated by indirect standardization of the World Health Organization population, with its confidence interval (95%). It was evaluated whether the patients had biochemical determinations, systolic blood pressure (SBP), and body mass index (BMI) at the beginning and at 12 months of their treatment. Results: The crude antipsychotic prescription prevalence was 23.8 ‰ (95% CI 23.0 - 24.6) and the adjusted prevalence was 10.1 ‰ (95% CI 9.5-10.7). 3702 patients were evaluated. The male:female ratio was 0.6. Median age 77.5 years (IQR 25-75: 59.5-86.1). Quetiapine was the most frequently prescribed. Initial determinations: Lipid profile 1804 (48.7%), blood glucose 2034 (54.9%), SBP 2546 (68.8%) and BMI 1584 (42.8%). At 12 months: Lipid profile 680 (18.4%), blood glucose 898 (24.3%), SAT 1609 (43.5%), and BMI 1584 (21.7%).  Conclusions: We observed a higher prevalence of atypical antipsychotic prescription in the elderly and female population and scarce registry of biochemical determinations for adverse effects follow-up.    Introducción: Los antipsicóticos incrementan la morbimortalidad por su impacto metabólico. Es escasa la información sobre su prescripción y seguimiento. El objetivo fue estimar la prevalencia de prescripción de antipsicóticos crónicos y evaluar el monitoreo metabólico.  Métodos: Cohorte retrospectiva de pacientes ambulatorios mayores de 18 años de un hospital de Argentina. Se estimó la prevalencia cruda y ajustada de prescripción crónica de antipsicóticos mediante estandarización indirecta por la población de la Organización Mundial de la Salud (OMS), con su intervalo de confianza 95%. Se evaluó si los pacientes en tratamiento tenían determinaciones bioquímicas, tensión arterial sistólica (TAS) e índice de masa corporal (IMC), al inicio y a los 12 meses.  Resultados: La prevalencia cruda de prescripción de antipsicóticos fue 23,8‰ (IC del 95% 23,0 – 24,6) y la ajustada fue 10,1 ‰ (95% CI 9,5-10,7). Se evaluaron 3702 pacientes. La razón hombre/mujer fue 0,6. La mediana de edad 77,5 años (IQR 25-75: 59,5-86,1). Predominó quetiapina. Pacientes con determinaciones al inicio: lipidograma 1804 (48,7%), glucemia 2034 (54,9 %), TAS 2546 (68,8 %) e IMC 1584 (42,8%). A los 12 meses: lipidograma 680 (18,4%), glucemia 898 (24,3%), TAS 1609 (43,5%) e IMC 1584 (21,7%).  Conclusiones: Observamos una mayor prescripción de antipsicóticos atípicos en la población anciana y femenina, y un escaso registro de determinaciones clínico-bioquímicas para control de efectos adversos.  Introdução: Os antipsicóticos aumentam a morbimortalidade devido ao seu impacto metabólico. As informações sobre sua prescrição e acompanhamento são escassas. O objetivo foi estimar a prevalência da prescrição de antipsicóticos crônicos e avaliar o monitoramento metabólico.  Métodos: Cohorte retrospectiva de pacientes ambulatoriais maiores de 18 anos de um hospital na Argentina. A prevalência bruta e ajustada da prescrição de antipsicóticos crônicos foi estimada por padronização indireta pela população da Organização Mundial da Saúde, com seu intervalo de confiança (95%). Foi avaliado se os pacientes em tratamento apresentavam determinações bioquímicas, pressão arterial sistólica (PAS) e índice de massa corporal (IMC), no início e aos 12 meses. Resultados: A prevalência da prescrição bruta de antipsicóticos foi de 23,8 ‰ (IC95% 23,0 - 24,6) e ajustada foi de 10,1 ‰ (IC95% 9,5-10,7). 3702 pacientes foram avaliados. A razão homem: mulher foi de 0,6. A idade mediana foi de 77,5 anos (IIQ 25-75 : 59,5-86,1). Com predomínio da quetiapina. Pacientes com determinações no início: lipidograma 1804 (48,7%), glicemia 2034 (54,9%), PAS 2546 (68,8%) e IMC 1584 (42,8%). Aos 12 meses: lipidograma 680 (18,4%), glicemia 898 (24,3%), PAS 1609 (43,5%) e IMC 1584 (21,7%). Conclusões: Observamos uma maior prescrição de antipsicóticos atípicos na população idosa e feminina, e escasso registro de determinações clínico-bioquímicas para controle de efeitos adversos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-09-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/32653 10.31053/1853.0605.v78.n3.32653 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 3 (2021); 276-282 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 3 (2021); 276-282 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 3 (2021); 276-282 1853-0605 0014-6722 10.31053/1853.0605.v78.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/32653/35084 https://revistas.unc.edu.ar/index.php/med/article/view/32653/35085 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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