Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome.
INTRODUCTION: Intermittent chronic hypoxia produced during obstructive sleep apneas (OSA) leads to oxidative stress, and consequently to a state of systemic inflammation. There are no biomarkers that assess the degree of inflammation and are related to the severity of this disease. The red cell dist...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/30397 |
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I10-R327-article-30397 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
Sleep Apnea Syndromes Biomarkers Inflammation Síndromes de la Apnea del Sueño Biomarcadores Inflamación Síndromes da Apneia do Sono Biomarcadores Inflamação |
| spellingShingle |
Sleep Apnea Syndromes Biomarkers Inflammation Síndromes de la Apnea del Sueño Biomarcadores Inflamación Síndromes da Apneia do Sono Biomarcadores Inflamação Camporro, Fernando Astur Kevorkof, Gregorio Varujan Gallmann, Ana Gazzoni, Florencia Bulacio , Exequiel Gutierrez Magaldi, Ignacio Borsini, Eduardo Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| topic_facet |
Sleep Apnea Syndromes Biomarkers Inflammation Síndromes de la Apnea del Sueño Biomarcadores Inflamación Síndromes da Apneia do Sono Biomarcadores Inflamação |
| author |
Camporro, Fernando Astur Kevorkof, Gregorio Varujan Gallmann, Ana Gazzoni, Florencia Bulacio , Exequiel Gutierrez Magaldi, Ignacio Borsini, Eduardo |
| author_facet |
Camporro, Fernando Astur Kevorkof, Gregorio Varujan Gallmann, Ana Gazzoni, Florencia Bulacio , Exequiel Gutierrez Magaldi, Ignacio Borsini, Eduardo |
| author_sort |
Camporro, Fernando Astur |
| title |
Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| title_short |
Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| title_full |
Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| title_fullStr |
Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| title_full_unstemmed |
Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| title_sort |
relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. |
| description |
INTRODUCTION: Intermittent chronic hypoxia produced during obstructive sleep apneas (OSA) leads to oxidative stress, and consequently to a state of systemic inflammation. There are no biomarkers that assess the degree of inflammation and are related to the severity of this disease. The red cell distribution amplitude and the ultrasensitive reactive C protein are sensitive to the systemic inflammation generated by oxidative stress. We intend to correlate the reactive C protein and red cell distribution amplitude values with the degree of severity of OSA.
METHODS: An observational, prospective, analytical study was performed. OSA patients participated. Spearman's correlation coefficient was used to estimate the correlation between red cell distribution amplitude and reactive C protein with OSA severity according to apnea hypopnea index (AHI).
RESULTS: 95 patients participated, of which 79 were men. Only 10 (10.5%) patients presented normal BMI. The correlations between AHI with reactive C protein and red cell distribution amplitude were weak (r = 0.17; p = 0.1066 and r = 0.06; p = 0.5867, respectively). The correlations between T90 with reactive C protein and red cell distribution amplitude were also weak (r = 0.16; p = 0.1331 and r = 0.24; p = 0.0202, respectively). An association was found between red cell distribution amplitude greater than 14 and severe OSA (p = 0.0369) and with T90 greater than 10% (p = 0.0168).
CONCLUSIONS: Although the correlations between AHI and T90 with reactive C protein and red cell distribution amplitude were weak, it was found that severe patients, presented higher values of red cell distribution amplitude and higher T <90. This association could not be tested with reactive C protein. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/30397 |
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I10-R327-article-303972021-12-29T20:15:49Z Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. Relación entre marcadores inflamatorios y severidad del síndrome de apnea e hipopnea del sueño Relação entre marcadores inflamatórios e gravidade da da síndrome de apneia do sono e hipopnéia Camporro, Fernando Astur Kevorkof, Gregorio Varujan Gallmann, Ana Gazzoni, Florencia Bulacio , Exequiel Gutierrez Magaldi, Ignacio Borsini, Eduardo Sleep Apnea Syndromes Biomarkers Inflammation Síndromes de la Apnea del Sueño Biomarcadores Inflamación Síndromes da Apneia do Sono Biomarcadores Inflamação INTRODUCTION: Intermittent chronic hypoxia produced during obstructive sleep apneas (OSA) leads to oxidative stress, and consequently to a state of systemic inflammation. There are no biomarkers that assess the degree of inflammation and are related to the severity of this disease. The red cell distribution amplitude and the ultrasensitive reactive C protein are sensitive to the systemic inflammation generated by oxidative stress. We intend to correlate the reactive C protein and red cell distribution amplitude values with the degree of severity of OSA. METHODS: An observational, prospective, analytical study was performed. OSA patients participated. Spearman's correlation coefficient was used to estimate the correlation between red cell distribution amplitude and reactive C protein with OSA severity according to apnea hypopnea index (AHI). RESULTS: 95 patients participated, of which 79 were men. Only 10 (10.5%) patients presented normal BMI. The correlations between AHI with reactive C protein and red cell distribution amplitude were weak (r = 0.17; p = 0.1066 and r = 0.06; p = 0.5867, respectively). The correlations between T90 with reactive C protein and red cell distribution amplitude were also weak (r = 0.16; p = 0.1331 and r = 0.24; p = 0.0202, respectively). An association was found between red cell distribution amplitude greater than 14 and severe OSA (p = 0.0369) and with T90 greater than 10% (p = 0.0168). CONCLUSIONS: Although the correlations between AHI and T90 with reactive C protein and red cell distribution amplitude were weak, it was found that severe patients, presented higher values of red cell distribution amplitude and higher T <90. This association could not be tested with reactive C protein. INTRODUCCION: La hipoxia crónica intermitente producida durante las apneas obstructivas del sueño (AOS) conduce a estrés oxidativo, y consecuentemente a un estado de inflamación sistémica. No se dispone de biomarcadores que evalúen el grado de inflamación y se relacionen con la severidad de esta enfermedad. La amplitud de distribución eritrocitaria (ADE) y la Proteína C Reactiva ultrasensible (PCRus), son sensibles a la inflamación sistémica generada por el estrés oxidativo. Pretendemos correlacionar los valores de PCR y ADE con el grado de severidad de AOS. METODOS: Se realizó un estudio observacional, prospectivo, analítico. Participaron pacientes con AOS. Para estimar la correlación entre el ADE y PCR con la gravedad del SAOS según IAH se utilizó el coeficiente de correlación de Spearman. RESULTADOS: Participaron 95 pacientes, de los cuales 79 fueron hombres. Solo 10 (10.5%) pacientes presentaron IMC normal. Las correlaciones entre IAH con PCR y ADE fueron débiles (r=0,17; p=0,1066 y r=0.06; p=0.5867, respectivamente). También fueron débiles las correlaciones entre T90 con PCR y ADE (r=0,16; p=0,1331 y r=0,24; p=0,0202, respectivamente). Se encontró una asociación entre ADE mayor a 14 y AOS severo (p=0.0369) y entre ADE mayor a 14 y T90 mayor al 10% (p=0.0168). CONCLUSIONES: Si bien las correlaciones entre IAH y T90 con PCR y ADE fueron débiles, se halló que los pacientes severos, presentaron mayores valores de ADE y mayor T<90. Esta asociación no pudo ser probada con la PCR. INTRODUÇÃO: A hipóxia crônica intermitente produzida durante as apneias obstrutivas do sono (AOS) leva ao estresse oxidativo e, consequentemente, a um estado de inflamação sistêmica. Não existem biomarcadores que avaliem o grau de inflamação e estejam relacionados com a gravidade da doença. A largura de distribuição eritrocitária (LDE) e a proteína C reativa ultrassensível (PCRus) são sensíveis à inflamação sistêmica gerada pelo estresse oxidativo. Pretendemos correlacionar os valores de PCR e LDE com o grau de gravidade da SAOS. MÉTODOS: Foi realizado um estudo observacional, prospectivo e analítico. Pacientes com AOS participaram. Para estimar a correlação entre LDE e PCR com a gravidade da AOS de acordo com o IAH, foi utilizado o coeficiente de correlação de Spearman. RESULTADOS: Participaram 95 pacientes, dos quais 79 eram homens. Apenas 10 (10,5%) pacientes apresentavam IMC normal. As correlações entre IAH com PCR e LDE foram fracas (r = 0,17; p = 0,1066 er = 0,06; p = 0,5867, respectivamente). As correlações entre T90 com PCR e LDE também foram fracas (r = 0,16; p = 0,1331 er = 0,24; p = 0,0202, respectivamente). Foi encontrada associação entre LDE maior que 14 e AOS grave (p = 0,0369) e entre LDE maior que 14 e T90 maior que 10% (p = 0,0168). CONCLUSÕES: Embora as correlações entre IAH e T90 com PCR e RDW sejam fracas, verificou-se que pacientes graves apresentaram maiores valores de RDW e maior T <90. Esta associação não pode ser comprovada com PCR. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-06-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/30397 10.31053/1853.0605.v78.n2.30397 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 2 (2021); 137-141 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 2 (2021); 137-141 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 2 (2021); 137-141 1853-0605 0014-6722 10.31053/1853.0605.v78.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/30397/33650 https://revistas.unc.edu.ar/index.php/med/article/view/30397/33651 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |