Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study
BACKGRUOUND: Chronic Obstructive Pulmonary Disease (COPD), a preventable and underdiagnosed pathology, can be defined as a progressive and poorly reversible limitation to airflow as a result of a persistent inflammatory response due to inhalation of harmful substances, particularly tobacco smoke. Th...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/28721 |
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I10-R327-article-28721 |
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ojs |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
pulmonary disease, chronic obstructive cognitive dysfunction tobacco use disorder COPD enfermedad pulmonar obstructiva crónica disfunción cognitiva tabaquismo EPOC doença pulmonar obstrutiva crônica disfunção cognitiva tabagismo DPOV |
| spellingShingle |
pulmonary disease, chronic obstructive cognitive dysfunction tobacco use disorder COPD enfermedad pulmonar obstructiva crónica disfunción cognitiva tabaquismo EPOC doença pulmonar obstrutiva crônica disfunção cognitiva tabagismo DPOV Varela, Lucía Belen Correa, Facundo Cazaux, Alexis Spaccesi, Agostina Salica, Daniel Antonio Vanoni, Susana Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| topic_facet |
pulmonary disease, chronic obstructive cognitive dysfunction tobacco use disorder COPD enfermedad pulmonar obstructiva crónica disfunción cognitiva tabaquismo EPOC doença pulmonar obstrutiva crônica disfunção cognitiva tabagismo DPOV |
| author |
Varela, Lucía Belen Correa, Facundo Cazaux, Alexis Spaccesi, Agostina Salica, Daniel Antonio Vanoni, Susana |
| author_facet |
Varela, Lucía Belen Correa, Facundo Cazaux, Alexis Spaccesi, Agostina Salica, Daniel Antonio Vanoni, Susana |
| author_sort |
Varela, Lucía Belen |
| title |
Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| title_short |
Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| title_full |
Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| title_fullStr |
Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| title_full_unstemmed |
Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study |
| title_sort |
stable chronic obstructive pulmonary disease associated with cognitive impairment: possible causality factor: pilot study |
| description |
BACKGRUOUND: Chronic Obstructive Pulmonary Disease (COPD), a preventable and underdiagnosed pathology, can be defined as a progressive and poorly reversible limitation to airflow as a result of a persistent inflammatory response due to inhalation of harmful substances, particularly tobacco smoke. The disease has a systemic impact. Among other conditions, it may increase the risk of cognitive impairment along with its associated consequences. METHODS: Prospective, cross-sectional, observational and analytical design. The space were COPD patients who visited in two health institutions from June 2017 to September 2018. Non-probabilistic and convenience sampling. Data were collected on demographics, tobacco consumption, comorbidities (Charlson index), a validated scale for dyspnea (MCRm), the main symptom in COPD and the COPD Assessment Test (CAT) were applied along with a history of exacerbation of the disease. The severity of COPD was evaluated by spirometry according to GOLD guideline. Cognitive impairment was assessed using Neuropsi. OUTCOMES: The final sample consisted of 44 subjects. According to spirometry and GOLD, 7 patients (15.9%) classified in group 1 (mild), 19 (43.2%) in group 2 (moderate), 11 (25%) in group 3 (severe) and 7 (15.9%) in group 4 (very serious). Of the 44 patients recruited, 28 (63.6%) had normal cognitive function and 16 (36.3%) had some degree of cognitive impairment. Memory was the most compromised function. CONCLUSION: Difficulties in recruitment impeded reaching the expected sample size. However, a trend was observed favoring the association. It is important to insist on avoiding smoking because it seems to increase the risk of cognitive impairment that further disrupts the quality of life and makes treatment difficult. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/28721 |
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I10-R327-article-287212024-08-27T18:28:24Z Stable Chronic Obstructive Pulmonary Disease Associated With Cognitive Impairment: Possible Causality Factor: Pilot Study La enfermedad pulmonar obstructiva crónica estable asociada a deterioro cognitivo: posible factor de causalidad: Estudio piloto A doença pulmonar obstrutiva crônica estável associada à deterioração cognitiva: possível fator de causalidade: Estudo piloto Varela, Lucía Belen Correa, Facundo Cazaux, Alexis Spaccesi, Agostina Salica, Daniel Antonio Vanoni, Susana pulmonary disease, chronic obstructive cognitive dysfunction tobacco use disorder COPD enfermedad pulmonar obstructiva crónica disfunción cognitiva tabaquismo EPOC doença pulmonar obstrutiva crônica disfunção cognitiva tabagismo DPOV BACKGRUOUND: Chronic Obstructive Pulmonary Disease (COPD), a preventable and underdiagnosed pathology, can be defined as a progressive and poorly reversible limitation to airflow as a result of a persistent inflammatory response due to inhalation of harmful substances, particularly tobacco smoke. The disease has a systemic impact. Among other conditions, it may increase the risk of cognitive impairment along with its associated consequences. METHODS: Prospective, cross-sectional, observational and analytical design. The space were COPD patients who visited in two health institutions from June 2017 to September 2018. Non-probabilistic and convenience sampling. Data were collected on demographics, tobacco consumption, comorbidities (Charlson index), a validated scale for dyspnea (MCRm), the main symptom in COPD and the COPD Assessment Test (CAT) were applied along with a history of exacerbation of the disease. The severity of COPD was evaluated by spirometry according to GOLD guideline. Cognitive impairment was assessed using Neuropsi. OUTCOMES: The final sample consisted of 44 subjects. According to spirometry and GOLD, 7 patients (15.9%) classified in group 1 (mild), 19 (43.2%) in group 2 (moderate), 11 (25%) in group 3 (severe) and 7 (15.9%) in group 4 (very serious). Of the 44 patients recruited, 28 (63.6%) had normal cognitive function and 16 (36.3%) had some degree of cognitive impairment. Memory was the most compromised function. CONCLUSION: Difficulties in recruitment impeded reaching the expected sample size. However, a trend was observed favoring the association. It is important to insist on avoiding smoking because it seems to increase the risk of cognitive impairment that further disrupts the quality of life and makes treatment difficult. INTRODUCCIÓN: La enfermedad pulmonar obstructiva crónica (EPOC) se define como limitación progresiva y poco reversible al flujo aéreo a consecuencia de una respuesta inflamatoria por inhalación sustancias, en particular humo del tabaco. La enfermedad tiene repercusión sistémica y entre otras, puede aumentar el riesgo de deterioro cognitivo. MATERIALES Y MÉTODOS: Diseño prospectivo, transversal, observacional y analítico. El universo fueron pacientes EPOC que consultaron en dos instituciones de salud desde junio de 2017 a septiembre de 2018. Muestreo no probabilístico, por conveniencia. Se recogieron datos demográficos, de comorbilidades, se aplicó la escalaMCRm de disnea y se valoraron antecedentes de exacerbación de la enfermedad. La gravedad de la EPOC se reconoció por espirometría de acuerdo a GOLD. El deterioro cognitivo fue evaluado mediante el Neuropsi. RESULTADOS: La muestra final incluyó 44 sujetos. De acuerdo a espirometría y GOLD 7 pacientes (15,9 %) clasificaron en el grupo 1 (leve), 19 (43,2 %) en el 2 (moderado), 11 (25 %) en el 3 (grave) y 7 (15,9 %) en el 4 (muy grave). De los 44 pacientes reclutados, 28 (63,6 %) presentaron una función cognitiva normal y 16 (36,3 %), algún grado de alteración cognitiva. La memoria fue la función más comprometida. CONCLUSIONES: Dificultades en el reclutamiento impidieron alcanzar el tamaño de muestra esperado. Sin embargo, se observó una tendencia a favor de la asociación. Resulta importante insistir en evitar el tabaquismo pues este parece incrementar el riesgo de deterioro cognitivo que perturba aún más la calidad de vida y dificulta el tratamiento. INTRODUÇÃO: A doença pulmonar obstrutiva crônica (DPOC) é definida como a limitação progressiva e pouco reversível ao fluxo de ar como resultado de uma resposta inflamatória por substâncias inalatórias, em particular a fumaça do tabaco. A doença tem repercussão sistêmica e, entre outras, pode aumentar o risco de comprometimento cognitivo. MATERIAIS E MÉTODOS: Desenho prospectivo, transversal, observacional e analítico. O universo foram pacientes com DPOC que consultaram em duas instituições de saúde de junho de 2017 a setembro de 2018. Amostragem não probabilística, por conveniência. Os dados demográficos das comorbidades foram coletados, a escala MDRM de dispnéia foi aplicada e uma história de exacerbação da doença foi avaliada. A gravidade da DPOC foi reconhecida pela espirometria, segundo o GOLD. O comprometimento cognitivo foi avaliado polo Neuropsi. RESULTADOS: A amostra final incluiu 44 sujeitos. De acordo com a espirometria e o GOLD, 7 pacientes (15,9%) foram classificados no grupo 1 (leve), 19 (43,2%) no 2 (moderado), 11 (25%) no 3 (grave) e 7 (15,9%) no 4 (muito grave). Dos 44 pacientes recrutados, 28 (63,6%) apresentavam função cognitiva normal e 16 (36,3%), algum grau de comprometimento cognitivo. A memória foi a função mais comprometida. CONCLUSÕES: Dificuldades no recrutamento impediram o tamanho esperado da amostra. No entanto, uma tendência foi observada a favor da associação. É importante insistir em evitar o tabagismo, pois parece aumentar o risco de comprometimento cognitivo que atrapalha ainda mais a qualidade de vida e dificulta o tratamento. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-06-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/28721 10.31053/1853.0605.v78.n2.28721 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 2 (2021); 97-102 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 2 (2021); 97-102 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 2 (2021); 97-102 1853-0605 0014-6722 10.31053/1853.0605.v78.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/28721/33563 https://revistas.unc.edu.ar/index.php/med/article/view/28721/33402 Derechos de autor 2021 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |