Coronavirus disease (COVID-19) and sirtuins
The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data source and selection: For this, a search was made in Medline, Scopus and WO...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2020
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/28196 |
| Aporte de: |
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I10-R327-article-28196 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
Coronavirus infections Neoplasms Histone deacetylases NAD Sirtuins Infecciones por coronavirus neoplasias Inhibidores de Histona Desacetilasas NAD Sirtuinas Infecções por Coronavirus neoplasias Inibidores de Histona Desacetilases NAD Sirtuinas |
| spellingShingle |
Coronavirus infections Neoplasms Histone deacetylases NAD Sirtuins Infecciones por coronavirus neoplasias Inhibidores de Histona Desacetilasas NAD Sirtuinas Infecções por Coronavirus neoplasias Inibidores de Histona Desacetilases NAD Sirtuinas Huarachi Olivera, Ronald Eleazar Lazarte Rivera, Antonio Coronavirus disease (COVID-19) and sirtuins |
| topic_facet |
Coronavirus infections Neoplasms Histone deacetylases NAD Sirtuins Infecciones por coronavirus neoplasias Inhibidores de Histona Desacetilasas NAD Sirtuinas Infecções por Coronavirus neoplasias Inibidores de Histona Desacetilases NAD Sirtuinas |
| author |
Huarachi Olivera, Ronald Eleazar Lazarte Rivera, Antonio |
| author_facet |
Huarachi Olivera, Ronald Eleazar Lazarte Rivera, Antonio |
| author_sort |
Huarachi Olivera, Ronald Eleazar |
| title |
Coronavirus disease (COVID-19) and sirtuins |
| title_short |
Coronavirus disease (COVID-19) and sirtuins |
| title_full |
Coronavirus disease (COVID-19) and sirtuins |
| title_fullStr |
Coronavirus disease (COVID-19) and sirtuins |
| title_full_unstemmed |
Coronavirus disease (COVID-19) and sirtuins |
| title_sort |
coronavirus disease (covid-19) and sirtuins |
| description |
The NAD+dependent proteins deacetylases are called Sirtuins (SIRT).
Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19.
Data source and selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. SIRT2 is regulated by the secretion of IL-4 by eosinophils and the increase in SIRT2 increases hyperplasia, in contrast, SIRT3 promotes angiogenesis, inducing cardiac remodeling. SIRT4 is a tumor suppressor, in contrastto SIRT5 that promotes cell proliferation causing colorectal cancer; SIRT6 attenuates herpes virus associated with Kaposi's Sarcoma (KSHV) in immune compromised patients. Suppression of SIRT7 inhibits the growth of endometrial cancer cells.
Conclusions: It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2020 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/28196 |
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2024-09-03T21:01:53Z |
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2024-09-03T21:01:53Z |
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I10-R327-article-281962024-08-27T18:28:07Z Coronavirus disease (COVID-19) and sirtuins Enfermedad del coronavirus (covid-19) y las sirtuinas Doença de coronavírus (COVID-19) e sirtuínas Huarachi Olivera, Ronald Eleazar Lazarte Rivera, Antonio Coronavirus infections Neoplasms Histone deacetylases NAD Sirtuins Infecciones por coronavirus neoplasias Inhibidores de Histona Desacetilasas NAD Sirtuinas Infecções por Coronavirus neoplasias Inibidores de Histona Desacetilases NAD Sirtuinas The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data source and selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. SIRT2 is regulated by the secretion of IL-4 by eosinophils and the increase in SIRT2 increases hyperplasia, in contrast, SIRT3 promotes angiogenesis, inducing cardiac remodeling. SIRT4 is a tumor suppressor, in contrastto SIRT5 that promotes cell proliferation causing colorectal cancer; SIRT6 attenuates herpes virus associated with Kaposi's Sarcoma (KSHV) in immune compromised patients. Suppression of SIRT7 inhibits the growth of endometrial cancer cells. Conclusions: It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes. Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. Fuente y selección de datos: Para ello se realizó una búsqueda en Medline, Scopus y WOS, donde se incluyeron estudios descriptivos de cada una de las funciones de las sirtuinas ajustado a las recientes investigaciones científicas. La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, siendo susceptibles a infecciones por SARS CoV-2. La SIRT2 se regula por la secreción de IL-4 por los eosinófilos y el aumento de SIRT2 incrementa la hiperplasia, en contraste la SIRT3 promueve la angiogénesis, induciendo la remodelación cardiaca. La SIRT4 es un supresor de tumores, en contraste con la SIRT5 que promueve la proliferación celular provocando el cáncer colorrectal; la SIRT6 atenúa al herpes virus asociado al Sarcoma de Kaposi (KSHV) en pacientes inmuno comprometidos. La supresión de SIRT7 inhibe el crecimiento de las células cancerígenas endometriales. Conclusiones: Se concluye que las SIRT1, SIRT2 y SIRT4 están involucradas en el desarrollo del cáncer, la supresión de SIRT5 y SIRT7 promueve la apoptosis de células cancerígenas y la SIRT6 atenúa la replicación de KSHV, además la vía de patología molecular de la COVID-19 está asociada a la inhibición de la actividad de SIRT1 que puede estar relacionada a procesos inflamatorios. As proteínas desacetilases dependentes de NAD + são chamadas Sirtuins (SIRT). Objetivos: destarevisão é estudar as sirtuínas envolvidas no câncer, bem como estudos de inibição da SIRT1 em pacientes com doença de coronavírus COVID-19. Fonte e seleção dos dados: Para isso, foi realizada uma pesquisa no Medline, Scopus e WOS, onde foram incluídos estudos descritivos de cada uma das funções das sirtuínas, ajustados às pesquisas científicas recentes. À inibição da SIRT1 diminui a citotoxicidade das células T CD8 em pacientes com Lúpus Eritematoso Sistêmico sendo suscetível a infecções por SARS Cov-2. O SIRT2 é regulado pela secreção de IL-4 pelos eosinófilos e o aumento do SIRT2 aumenta a hiperplasia, enquanto o SIRT3 promove a angiogênese, induzindo a remodelação cardíaca. SIRT4 é um supressor de tumor, em contraste com o SIRT5, que promove a proliferação celular causando cáncer colorretal; O SIRT6 atenua o vírus do herpes associadoao Sarcoma de Kaposi (KSHV) em pacientes imunocomprometidos. A supressão de SIRT7 inibe o crescimento de células cancerígenas endometriais. Conclusões: Conclui-se que SIRT1, SIRT2 e SIRT4 estão envolvidos no desenvolvimento do câncer, a supressão de SIRT5 e SIRT7 promove a apoptose das células cancerígenas e o SIRT6 atenua a replicação do KSHV, alémdisso, a via da patologia molecular do COVID-19 é associado à inibição da atividade da SIRT1 que pode estar relacionada a procesos inflamatórios. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-06-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html text/html https://revistas.unc.edu.ar/index.php/med/article/view/28196 10.31053/1853.0605.v77.n2.28196 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 77 No. 2 (2020); 117-125 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm. 2 (2020); 117-125 Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 2 (2020); 117-125 1853-0605 0014-6722 10.31053/1853.0605.v77.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/28196/29899 https://revistas.unc.edu.ar/index.php/med/article/view/28196/29900 Derechos de autor 2020 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |