Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment
Introduction: continuous growth monitoring allows the identification of anthropometric and metabolic disorders as an integral part of HIV treatment. It was proposed to analyze the evolution of nutritional status, with the immunological and virological parameters in children infected with vertically...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/28147 |
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I10-R327-article-28147 |
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Universidad Nacional de Córdoba |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
nutritional status anthropometry child HIV estado nutricional antropometría niño VIH estado nutricional antropometria criança HIV |
| spellingShingle |
nutritional status anthropometry child HIV estado nutricional antropometría niño VIH estado nutricional antropometria criança HIV Oberto, María Georgina Asis, Elizabeth Liliana Defagó, María Daniela Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| topic_facet |
nutritional status anthropometry child HIV estado nutricional antropometría niño VIH estado nutricional antropometria criança HIV |
| author |
Oberto, María Georgina Asis, Elizabeth Liliana Defagó, María Daniela |
| author_facet |
Oberto, María Georgina Asis, Elizabeth Liliana Defagó, María Daniela |
| author_sort |
Oberto, María Georgina |
| title |
Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| title_short |
Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| title_full |
Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| title_fullStr |
Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| title_full_unstemmed |
Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment |
| title_sort |
evolution of nutritional status, immunological and virological parameters in children with vertically transmitted hiv under antiretroviral treatment |
| description |
Introduction: continuous growth monitoring allows the identification of anthropometric and metabolic disorders as an integral part of HIV treatment. It was proposed to analyze the evolution of nutritional status, with the immunological and virological parameters in children infected with vertically transmitted HIV and its association with highly active antiretroviral treatment (HAART).
Material and Methods: were included 56 children aged 0 to 12 years, attending the Hospital Materno Neonatal of Córdoba, Argentina between 1998-2014. Anthropometric and biochemical, immunological, virological nutritional status and clinical manifestations were evaluated by age group (younger or older than 6 years) and HAART administered in three medical controls.
Results: in the third control the analysis of the anthropometric nutritional status according to the body mass index (BMI) diagnosed 47 children (83.93%) with a normal BMI and 6 (10.71%) overweight/obesity, without statistically significant difference by age group (p=0.10). Thirty six children (64.29%) presented hypertriglyceridemia, with higher concentrations at the second (p=0.003) and third control (p=0.06) in those treated with scheme II and III with protease inhibitors (PI), unlike scheme I without IP. Normoglycemia prevailed in 54 children (96.43%) and anemia in 29 (51.79%).
The clinical manifestations decreased in the successive controls and in the last one, 3 children (5.36%) older than 6 years, had pneumonia and one (1.79%) severe immunosuppression.
Conclusions: hypertriglyceridemia was the main adverse effect of the medication, which, added to the high prevalence of anemia, constitute important parameters for interdisciplinary treatment. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/28147 |
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I10-R327-article-281472024-08-27T18:28:02Z Evolution of nutritional status, immunological and virological parameters in children with vertically transmitted HIV under antiretroviral treatment Evolución del estado nutricional, parámetros inmunológicos y virológicos en niños con VIH de transmisión vertical bajo tratamiento antirretroviral Evolução do estado nutricional, parâmetros imunológicos e virológicos em crianças com HIV transmitido verticalmente sob tratamento antiretroviral Oberto, María Georgina Asis, Elizabeth Liliana Defagó, María Daniela nutritional status anthropometry child HIV estado nutricional antropometría niño VIH estado nutricional antropometria criança HIV Introduction: continuous growth monitoring allows the identification of anthropometric and metabolic disorders as an integral part of HIV treatment. It was proposed to analyze the evolution of nutritional status, with the immunological and virological parameters in children infected with vertically transmitted HIV and its association with highly active antiretroviral treatment (HAART). Material and Methods: were included 56 children aged 0 to 12 years, attending the Hospital Materno Neonatal of Córdoba, Argentina between 1998-2014. Anthropometric and biochemical, immunological, virological nutritional status and clinical manifestations were evaluated by age group (younger or older than 6 years) and HAART administered in three medical controls. Results: in the third control the analysis of the anthropometric nutritional status according to the body mass index (BMI) diagnosed 47 children (83.93%) with a normal BMI and 6 (10.71%) overweight/obesity, without statistically significant difference by age group (p=0.10). Thirty six children (64.29%) presented hypertriglyceridemia, with higher concentrations at the second (p=0.003) and third control (p=0.06) in those treated with scheme II and III with protease inhibitors (PI), unlike scheme I without IP. Normoglycemia prevailed in 54 children (96.43%) and anemia in 29 (51.79%). The clinical manifestations decreased in the successive controls and in the last one, 3 children (5.36%) older than 6 years, had pneumonia and one (1.79%) severe immunosuppression. Conclusions: hypertriglyceridemia was the main adverse effect of the medication, which, added to the high prevalence of anemia, constitute important parameters for interdisciplinary treatment. Introducción: la vigilancia del crecimiento de manera continua permite la identificación de alteraciones antropométricas y metabólicas como parte integral del tratamiento en VIH. Se propuso analizar la evolución del estado nutricional, con los parámetros inmunológicos y virológicos en niños infectados con VIH de transmisión vertical y su asociación con el tratamiento antirretroviral de gran actividad (TARGA). Material y Métodos: se incluyeron 56 niños de 0-12 años, asistentes al Hospital Materno Neonatal de Córdoba, Argentina entre 1998-2014. Se evaluó, por grupo etario (menor o mayor de 6 años) y TARGA administrado, el estado nutricional antropométrico y bioquímico, inmunológico, virológico y manifestaciones clínicas en tres controles médicos. Resultados: en el tercer control el análisis del estado nutricional antropométrico según el índice de masa corporal (IMC) diagnosticó 47 niños (83,93%) con un IMC normal y 6 (10,71%) sobrepeso/obesidad, sin diferencia estadísticamente significativa por grupo etario (p=0,10). Treinta y seis niños (64,29%) presentaron hipertrigliceridemia, siendo mayores las concentraciones al segundo (p=0,003) y tercer control (p=0,06) en los tratados con esquema II y III con inhibidores de proteasa (IP), a diferencia del esquema I sin IP. La normoglucemia prevaleció en 54 niños (96,43%) y la anemia en 29 (51,79%). Las manifestaciones clínicas disminuyeron en los sucesivos controles y en el último, 3 niños (5,36%) mayores de 6 años, tuvieron neumonía y uno (1,79%) inmunosupresión grave. Conclusiones: la hipertrigliceridemia fue el principal efecto adverso de la medicación que, sumados a la alta prevalencia de anemia, constituyen parámetros importantes para el tratamiento de manera interdisciplinaria. Introdução: o monitoramento contínuo do crescimento permite identificar distúrbios antropométricos e metabólicos como parte integrante do tratamento do HIV. Foi proposto analisar a evolução do estado nutricional, com os parâmetros imunológicos e virológicos em crianças infectadas com HIV transmitido verticalmente e sua associação com tratamento antirretroviral altamente ativo (HAART). Material e Métodos: Foram incluídas 56 crianças de 0 a 12 anos, atendidas no Hospital Materno Neonatal de Córdoba, Argentina, entre 1998 e 2014. O estado nutricional antropométrico e bioquímico, imunológico, virológico e as manifestações clínicas foram avaliadas por faixa etária (menor ou maior que 6 anos) e HAART administrado em três controles médicos. Resultados: no terceiro controle, a análise do estado nutricional antropométrico de acordo com o índice de massa corporal (IMC) diagnosticou 47 crianças (83,93%) com IMC normal e 6 (10,71%) sobrepeso/obesidade, sem diferença estatisticamente significante por faixa etária (p=0,10). Trinta e seis crianças (64,29%) apresentaram hipertrigliceridemia, com maiores concentrações no segundo (p=0,003) e terceiro controle (p=0,06) naquelas tratadas com os esquemas II e III com inibidores de protease (PI), ao contrário do esquema I sem IP. A normoglicemia prevaleceu em 54 crianças (96,43%) e a anemia em 29 (51,79%). As manifestações clínicas diminuíram nos controles sucessivos e, no último, 3 crianças (5,36%) com idade superior a 6 años apresentaram pneumonia e uma (1,79%) imunossupressão grave. Conclusões: a hipertrigliceridemia foi o principal efeito adverso do medicamento, que, somado à alta prevalência de anemia, constituem parâmetros importantes para o tratamento interdisciplinar. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-12-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/28147 10.31053/1853.0605.v78.n4.28147 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 4 (2021); 359-366 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 4 (2021); 359-366 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 4 (2021); 359-366 1853-0605 0014-6722 10.31053/1853.0605.v78.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/28147/35940 https://revistas.unc.edu.ar/index.php/med/article/view/28147/36205 Derechos de autor 2021 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |