Zika virus embryopathy in Argentina: clinical characteristics in newborns
Introduction: Microcephaly and brain abnormalities may be due to multiple etiologies, one of them is the congenital infection by Zika virus (ZIKV). From 2016 to the present, there has been a series of ZIKV outbreaks in Argentina. Method: National Network of Congenital Anomalies (RENAC) and...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2020
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/26754 |
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I10-R327-article-26754 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
congenital anomalies microcephaly Argentina Zika virus serological tests anomalías congénitas microcefalia Argentina virus Zika pruebas serológicas anormalidades congénitas microcefalia Argentina Zika virus testes sorológicos |
| spellingShingle |
congenital anomalies microcephaly Argentina Zika virus serological tests anomalías congénitas microcefalia Argentina virus Zika pruebas serológicas anormalidades congénitas microcefalia Argentina Zika virus testes sorológicos Tellechea, Ana Laura Bidondo, María Paz Luppo, Victoria Baricalla, Agustín Liascovich, Rosa Fabbri, Cintia Morales, María Alejandra Groisman, Boris Silva, María Masi, Patricia Israilev, Adriana Rocha, Marcela Ruth Quaglia, Marcela Escalante, Beatriz Villarreal, Alexandra Antinori, Marilena Barbero, Pablo Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| topic_facet |
congenital anomalies microcephaly Argentina Zika virus serological tests anomalías congénitas microcefalia Argentina virus Zika pruebas serológicas anormalidades congénitas microcefalia Argentina Zika virus testes sorológicos |
| author |
Tellechea, Ana Laura Bidondo, María Paz Luppo, Victoria Baricalla, Agustín Liascovich, Rosa Fabbri, Cintia Morales, María Alejandra Groisman, Boris Silva, María Masi, Patricia Israilev, Adriana Rocha, Marcela Ruth Quaglia, Marcela Escalante, Beatriz Villarreal, Alexandra Antinori, Marilena Barbero, Pablo |
| author_facet |
Tellechea, Ana Laura Bidondo, María Paz Luppo, Victoria Baricalla, Agustín Liascovich, Rosa Fabbri, Cintia Morales, María Alejandra Groisman, Boris Silva, María Masi, Patricia Israilev, Adriana Rocha, Marcela Ruth Quaglia, Marcela Escalante, Beatriz Villarreal, Alexandra Antinori, Marilena Barbero, Pablo |
| author_sort |
Tellechea, Ana Laura |
| title |
Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| title_short |
Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| title_full |
Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| title_fullStr |
Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| title_full_unstemmed |
Zika virus embryopathy in Argentina: clinical characteristics in newborns |
| title_sort |
zika virus embryopathy in argentina: clinical characteristics in newborns |
| description |
Introduction: Microcephaly and brain abnormalities may be due to multiple etiologies, one of them is the congenital infection by Zika virus (ZIKV). From 2016 to the present, there has been a series of ZIKV outbreaks in Argentina. Method: National Network of Congenital Anomalies (RENAC) and the National Institute of Viral Diseases (INEVH), under the National Administration of Laboratories and Health Institutes “Carlos Malbrán” (ANLIS), carry out the intensified surveillance of newborns with microcephaly and brain abnormalities. This article presents the clinical characteristics and laboratory testof patients detected with congenital infection by ZIKV between April 2016 to March 2018, Results: 10 cases with embryopathy were detected, six autochthonous and four imported; in two cases, the mothers were asymptomatic during pregnancy; all the cases presented microcephaly and cranial facial disproportion, ventriculomegaly in seven cases and in six cerebral calcifications. The diagnosis of congenital infection by Zika in the newborn was made by antigen-specific Immunoglobulin M (MAC-ELISA) and plaque-reduction neutralization test (PRNT90 ). PCR was negative in all cases. Conclusion: the patients presented clinical features that were consistent with those reported in other countries. The need for serological studies that allow confirmation is emphasized, ruling out cross-reactivity with other Flaviviruses. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2020 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/26754 |
| work_keys_str_mv |
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I10-R327-article-267542024-08-27T18:27:11Z Zika virus embryopathy in Argentina: clinical characteristics in newborns Embriopatía por virus Zika en Argentina: características clínicas y diagnóstico en recién nacidos Embriopatia pelo vírus zika na Argentina: características clínicas e diagnóstico em recém-nascidos Tellechea, Ana Laura Bidondo, María Paz Luppo, Victoria Baricalla, Agustín Liascovich, Rosa Fabbri, Cintia Morales, María Alejandra Groisman, Boris Silva, María Masi, Patricia Israilev, Adriana Rocha, Marcela Ruth Quaglia, Marcela Escalante, Beatriz Villarreal, Alexandra Antinori, Marilena Barbero, Pablo congenital anomalies microcephaly Argentina Zika virus serological tests anomalías congénitas microcefalia Argentina virus Zika pruebas serológicas anormalidades congénitas microcefalia Argentina Zika virus testes sorológicos Introduction: Microcephaly and brain abnormalities may be due to multiple etiologies, one of them is the congenital infection by Zika virus (ZIKV). From 2016 to the present, there has been a series of ZIKV outbreaks in Argentina. Method: National Network of Congenital Anomalies (RENAC) and the National Institute of Viral Diseases (INEVH), under the National Administration of Laboratories and Health Institutes “Carlos Malbrán” (ANLIS), carry out the intensified surveillance of newborns with microcephaly and brain abnormalities. This article presents the clinical characteristics and laboratory testof patients detected with congenital infection by ZIKV between April 2016 to March 2018, Results: 10 cases with embryopathy were detected, six autochthonous and four imported; in two cases, the mothers were asymptomatic during pregnancy; all the cases presented microcephaly and cranial facial disproportion, ventriculomegaly in seven cases and in six cerebral calcifications. The diagnosis of congenital infection by Zika in the newborn was made by antigen-specific Immunoglobulin M (MAC-ELISA) and plaque-reduction neutralization test (PRNT90 ). PCR was negative in all cases. Conclusion: the patients presented clinical features that were consistent with those reported in other countries. The need for serological studies that allow confirmation is emphasized, ruling out cross-reactivity with other Flaviviruses. Introducción: La microcefalia y las anomalías cerebrales congénitas pueden deberse a múltiples etiologías, siendo uno de ellas la infección congénita por el virus Zika (ZIKV). Desde 2016 hasta hoy se han sucedido una serie de brotes del ZIKV en Argentina. Métodos: La Red Nacional de Anomalías Congénitas (RENAC) y el Instituto Nacional de Enfermedades Virales (INEVH), dependientes de la Administración Nacional de Laboratorios e Institutos de Salud “Carlos Malbrán” (ANLIS), realizan la vigilancia intensificada de recién nacidos con microcefalia y anomalías cerebrales. Este trabajo presenta las características clínicas y estudios de laboratorio de los pacientes con infección congénita por ZIKV detectados entre abril de 2016 a marzo 2018. Resultados: se detectaron 10 casos con embriopatía, seis fueron autóctonos y cuatro importados; en dos casos las madres fueron asintomática durante el embarazo; todos los casos presentaron microcefalia y desproporción cráneo facial, ventriculomegalia en siete casos y en seis calcificaciones cerebrales. El diagnóstico de infección congénita por Zika en el recién nacido se realizó por estudios serológicos inmunoglobulina M antígeno específica (MAC-ELISA) y prueba de neutralización por reducción de placas (PRNT90). La PCR fue negativa en todos los casos. Conclusión: Los pacientes presentaron características clínicas coincidentes con las reportadas en otros países Se enfatiza la necesidad de estudios serológicos que permitan la confirmación, descartando la reactividad cruzada con otros Flavivirus Introdução: Microcefalia e anormalidades cerebrais congênitas podem ser causadas por múltiplas etiologias, sendo uma delas infecção congênita pelo vírus Zika (ZIKV). De 2016 a hoje, houve uma série de surtos de ZIKV na Argentina. Métodos: A Rede Nacional de Anomalias Congênitas (RENAC) e o Instituto Nacional de Doenças Virais (INEVH), da Administração Nacional de Laboratórios e Institutos de Saúde "Carlos Malbrán" (ANLIS), realizam a vigilância intensiva de recém-nascidos com microcefalia e anormalidades cerebrais. Este trabalho apresenta as características clínicas e estudos laboratoriais de pacientes com infecção congênita pelo ZIKV detectados entre abril de 2016 e março de 2018. Resultados: 10 casos com embriopatia foram detectados, seis nativos e quatro importados; em dois casos as mães eram assintomáticas durante a gravidez; Todos os casos apresentaram desproporção de microcefalia e crânio facial, ventriculomegalia em sete casos e em seis calcificações cerebrais. O diagnóstico de infecção congênita por zika no recém-nascido foi realizado por estudos sorológicos de antígeno específico da imunoglobulina M (MAC-ELISA) e teste de neutralização da redução de placa (PRNT90). A PCR foi negativa em todos os casos. Conclusão: Os pacientes apresentaram características clínicas coincidentes com as relatadas em outros países, enfatizando a necessidade de estudos sorológicos que permitam a confirmação, descartando a reatividade cruzada com outros flavivírus. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-04-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/26754 10.31053/1853.0605.v77.n2.26754 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 77 No. 2 (2020); 100-105 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm. 2 (2020); 100-105 Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 2 (2020); 100-105 1853-0605 0014-6722 10.31053/1853.0605.v77.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/26754/29485 https://revistas.unc.edu.ar/index.php/med/article/view/26754/29870 Derechos de autor 2020 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |