Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice
The genus Passiflora is widely used in medicinal folklore for the treatment mainly of anxiety. However, there are more studies on Passiflora incarnata. On the other hand, Passiflora coerulea (P. coerulea) is present in our country and is consumed as a tea...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/26170 |
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I10-R327-article-26170 |
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| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
phytomedicine passionflower anxiety depression fitomedicina passiflora ansiedad depresión |
| spellingShingle |
phytomedicine passionflower anxiety depression fitomedicina passiflora ansiedad depresión Diez, M Carlini, VP Chiarini, FE García, M Vergara Duveaux, EF Brizuela, NY Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| topic_facet |
phytomedicine passionflower anxiety depression fitomedicina passiflora ansiedad depresión |
| author |
Diez, M Carlini, VP Chiarini, FE García, M Vergara Duveaux, EF Brizuela, NY |
| author_facet |
Diez, M Carlini, VP Chiarini, FE García, M Vergara Duveaux, EF Brizuela, NY |
| author_sort |
Diez, M |
| title |
Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| title_short |
Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| title_full |
Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| title_fullStr |
Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| title_full_unstemmed |
Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| title_sort |
effects of the hydroalcoholic extract of passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice |
| description |
The genus Passiflora is widely used in medicinal folklore for the treatment mainly of anxiety. However, there are more studies on Passiflora incarnata. On the other hand, Passiflora coerulea (P. coerulea) is present in our country and is consumed as a tea by the population; the proportion of its active substance is different. Previous studies showed that P. coerulea acts as a partial agonist on the GABAA benzodiazepine receptor through called chrysin (flavonoid) in the acute treatment of rats. The aim of this study was to evaluate the effect of P. coerulea on anxiety and the expression of depressive behavior in Swiss albino mice with depression.
Swiss albino mice (N: NIH) with bilateral olfactory bulbectomy (animal depression model) were used in comparison to mice without extraction of olfactory bulbs (Sham, controls), N = 5-3. The antidepressant effect was assessed after 5 days of oral administration (gavage) of passionflower (10mg / kg) in the open field test (TCA) and anxiety behavior in the elevated labyrinth in cross (plus maze). The data were analyzed by two-way ANOVA followed by an LSD test.
The results show that sub-chronic treatment with P. coerulea in bulbectomized animals (BO) decreased locomotor activity in relation to BO - saline animals (p≤0.05). No significant differences were observed in Sham animals treated with P. coerulea with respect to Sham - saline (p≤0.05). In addition, BO-saline animals showed a significant decrease in % of entries (F (9.59) = 9.31; p≤ 0.05) and % of time in open arms (F (9.59) = 6,99; p≤0.05), which was reversed by the administration of P. coerulea, showing an anxiolytic effect.
In conclusion, this study provides new evidence about the effects of P. coerulea on the processes of anxiety and depression in an animal model of depression, where P. coerulea managed to reverse the anxiety and depressive behavior characteristic of BO animals. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/26170 |
| work_keys_str_mv |
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2024-09-03T21:01:27Z |
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2024-09-03T21:01:27Z |
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I10-R327-article-261702024-08-27T18:26:53Z Effects of the hydroalcoholic extract of Passiflora coerulea as an anxiolytic and antidepressant in subchronic treatment of mice Efectos del extracto hidroalcohólico de Passiflora coerulea como ansiolítico y antidepresivo en tratamiento subcrónico de ratones Diez, M Carlini, VP Chiarini, FE García, M Vergara Duveaux, EF Brizuela, NY phytomedicine passionflower anxiety depression fitomedicina passiflora ansiedad depresión The genus Passiflora is widely used in medicinal folklore for the treatment mainly of anxiety. However, there are more studies on Passiflora incarnata. On the other hand, Passiflora coerulea (P. coerulea) is present in our country and is consumed as a tea by the population; the proportion of its active substance is different. Previous studies showed that P. coerulea acts as a partial agonist on the GABAA benzodiazepine receptor through called chrysin (flavonoid) in the acute treatment of rats. The aim of this study was to evaluate the effect of P. coerulea on anxiety and the expression of depressive behavior in Swiss albino mice with depression. Swiss albino mice (N: NIH) with bilateral olfactory bulbectomy (animal depression model) were used in comparison to mice without extraction of olfactory bulbs (Sham, controls), N = 5-3. The antidepressant effect was assessed after 5 days of oral administration (gavage) of passionflower (10mg / kg) in the open field test (TCA) and anxiety behavior in the elevated labyrinth in cross (plus maze). The data were analyzed by two-way ANOVA followed by an LSD test. The results show that sub-chronic treatment with P. coerulea in bulbectomized animals (BO) decreased locomotor activity in relation to BO - saline animals (p≤0.05). No significant differences were observed in Sham animals treated with P. coerulea with respect to Sham - saline (p≤0.05). In addition, BO-saline animals showed a significant decrease in % of entries (F (9.59) = 9.31; p≤ 0.05) and % of time in open arms (F (9.59) = 6,99; p≤0.05), which was reversed by the administration of P. coerulea, showing an anxiolytic effect. In conclusion, this study provides new evidence about the effects of P. coerulea on the processes of anxiety and depression in an animal model of depression, where P. coerulea managed to reverse the anxiety and depressive behavior characteristic of BO animals. El género Passiflora es utilizado ampliamente en el folclore medicinal para el tratamiento principalmente de ansiedad. Sin embargo, existen mayores estudios sobre Passiflora incarnata. Por otro lado, Passiflora coerulea (P. coerulea) se encuentra en nuestro país y es consumida en forma de tisana por parte de la población y la proporción de sus principios activos es diferente. Estudios previos demostraron que P. coerulea actúa como agonista parcial sobre el receptor de benzodiacepinas GABAA a través llamado crisina (flavonoide) en el tratamiento agudo de ratas. El objetivo del presente trabajo fue evaluar el efecto de P. coerulea sobre la ansiedad y la expresión de la conducta de tipo depresiva en ratones albino Swiss con modelo de depresión. Se utilizaron ratones albino Swiss (N:NIH) con bulbectomía olfatoria bilateral (modelo animal de depresión) en comparación con ratones sin extracción de los bulbos olfatorios (Sham, controles), N = 5-3. El efecto antidepresivo se valoró luego de 5 días de la administración oral (gavage) de pasiflora (10mg/kg) en el test de campo abierto (TCA) y la conducta de ansiedad en el laberinto elevado en cruz (plus maze). Los datos fueron analizados por ANOVA de dos vías seguido por un test de LSD. Los resultados muestran que el tratamiento sub-crónico con P. coerulea en animales bulbectomizados (BO) disminuyó la actividad locomotora en relación a los animales BO - salina (p≤0,05). No se observaron diferencias significativas en los animales Sham tratados con P. coerulea respecto a los Sham - salina (p≤0,05). Además, los animales BO-salina mostraron una disminución significativa del % de entradas (F (9,59) = 9,31; p≤ 0,05) y el % de tiempo en brazos abiertos (F (9,59) = 6,99; p≤ 0,05), lo cual fue revertido por la administración de P. coerulea, mostrando un efecto ansiolítico. En conclusión, el presente trabajo aporta nuevas evidencias acerca de los efectos de P. coerulea sobre los procesos de ansiedad y depresión en un modelo animal de depresión, donde P. coerulea logró revertir la ansiedad y la conducta de tipo depresiva característica de los animales BO. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/26170 Revista de la Facultad de Ciencias Médicas de Córdoba.; 2019: Suplemento JIC XX Revista de la Facultad de Ciencias Médicas de Córdoba; 2019: Suplemento JIC XX Revista da Faculdade de Ciências Médicas de Córdoba; 2019: Suplemento JIC XX 1853-0605 0014-6722 10.31053/1853.0605.v76.nSuplemento spa https://revistas.unc.edu.ar/index.php/med/article/view/26170/27988 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |