Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)

The purpose of this study was to analyze the influence of diets varying in lipids and proteins on the histopathologic variety of  murine salivaiy tumors induced by DMBA. 117 BALB/c mice were assigned to experiments one (El: lipids, males) and  two (E2: proteins, males and fima1es)....

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Detalles Bibliográficos
Autores principales: Actis, Adriana B, Cremonezzi, David C, Carino, Silvia, Joekes, Silvia, Valentich, Mirta A
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Materias:
salivary glands
tumors
mice
dietary lipids
soy protein
histopathology
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25948
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-25948
record_format ojs
spelling I10-R327-article-259482024-08-27T18:26:38Z Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA) Influencia de dietas de diferente contenido lipídico y proteico sobre variantes histopatológicas de tumores de glándulas salivares murinos inducidos con 9, 10 - dimethyl- 1, 2 - benzathraceno (DMBA) Actis, Adriana B Cremonezzi, David C Carino, Silvia Joekes, Silvia Valentich, Mirta A salivary glands tumors mice dietary lipids soy protein histopathology The purpose of this study was to analyze the influence of diets varying in lipids and proteins on the histopathologic variety of  murine salivaiy tumors induced by DMBA. 117 BALB/c mice were assigned to experiments one (El: lipids, males) and  two (E2: proteins, males and fima1es). El comprising Soy oil (SO): Corn oil (CO. control); Fish oil (FO) and 01cm (0)  groups and E2, soy protein (SP) and casein (C) groups. Tumors were induced by DMBA and the animaJs were sacrificed  t week 13' post-induction. Tumor volume was calculated. Tumor sections were stained with HE for histopathologic  evaluation. No significant association was found between tumor volume and dietary condition (p> 0. 05). In El, FO  animais developed mainly carcinomas (C) (58,8%), the sarcomas (S) and carcinosarcomas (CS) being especially of  highgrade type (tumors <600 mm3). In E2, SP animais developed mainly C (55.61/1 o). Although no significantly  different (p>0.05), 5 and C were more frequent in female and maTe mice, respectively. In both El aral E2, the biggest tumors (>600 mm3) were mainly high-grade 5 (87.5%-80%). Dietary fat and soy protein appear to influence the tumor  histopathology and thus its prognosis. El objetivo de este estudio fue analizar la influencia de dietas con diferente contenido de lípidos y proteínas sobre la  variedad histopatológica de tumores salivales murinos inducidos por DMBA. Se asignaron 117 ratones BALB/c a los experimentos uno (El: lípidos, machos) y dos (E2: proteínas, machos y hembras). El comprendió a los grupos aceite de  soja (AS), aceite de maíz (AM, control), aceite de pescado (AP) y oleína (0), en tanto que E2 incluyó a los grupos proteína  de soja (PS) y caseína (C). Los tumores fueron inducidos por DMBA y los animales fueron sacrificados a la l3 semana post-inducción. Se calculó el volumen tumoral. Los cortes de tumor fueron coloreados con Hematoxilina-Eosina para su  evaluación histopatológica. No se encontró asociación entre volumen tumoral y condición dietaria (p>0.05). En El, los  animales del grupo AP desarrollaron principalmente carcinomas (C) (58,8%), en tanto que los sarcomas (S) y  arcinosarcomas (CS) fueron de alto grado (tumores <600 mm3). En E2. los animales del grupo PS desarrollaron principalmente C (55.6%). Aunque la diferencia no fue significativa (p>0.05), S C fueron más frecuentes en ratones  hembras y machos, respectivamente. Tanto en El como en E2, los tumores más voluminosos (>600 mm3) fueron principalmente S de alto grado (87.5%-80%). Los lípidos y la proteína de soja de la dieta parecen influenciar la histopatología de los tumores y. en consecuencia, su pronóstico. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25948 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 64 No. 2 (2007); 16 - 22 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 64 Núm. 2 (2007); 16 - 22 Revista da Faculdade de Ciências Médicas de Córdoba; v. 64 n. 2 (2007); 16 - 22 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/25948/27779 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic salivary glands
tumors
mice
dietary lipids
soy protein
histopathology
spellingShingle salivary glands
tumors
mice
dietary lipids
soy protein
histopathology
Actis, Adriana B
Cremonezzi, David C
Carino, Silvia
Joekes, Silvia
Valentich, Mirta A
Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
topic_facet salivary glands
tumors
mice
dietary lipids
soy protein
histopathology
author Actis, Adriana B
Cremonezzi, David C
Carino, Silvia
Joekes, Silvia
Valentich, Mirta A
author_facet Actis, Adriana B
Cremonezzi, David C
Carino, Silvia
Joekes, Silvia
Valentich, Mirta A
author_sort Actis, Adriana B
title Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
title_short Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
title_full Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
title_fullStr Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
title_full_unstemmed Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (DMBA)
title_sort influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9, 10 - dimethyl - 1, 2 - benzanthraceno (dmba)
description The purpose of this study was to analyze the influence of diets varying in lipids and proteins on the histopathologic variety of  murine salivaiy tumors induced by DMBA. 117 BALB/c mice were assigned to experiments one (El: lipids, males) and  two (E2: proteins, males and fima1es). El comprising Soy oil (SO): Corn oil (CO. control); Fish oil (FO) and 01cm (0)  groups and E2, soy protein (SP) and casein (C) groups. Tumors were induced by DMBA and the animaJs were sacrificed  t week 13' post-induction. Tumor volume was calculated. Tumor sections were stained with HE for histopathologic  evaluation. No significant association was found between tumor volume and dietary condition (p> 0. 05). In El, FO  animais developed mainly carcinomas (C) (58,8%), the sarcomas (S) and carcinosarcomas (CS) being especially of  highgrade type (tumors <600 mm3). In E2, SP animais developed mainly C (55.61/1 o). Although no significantly  different (p>0.05), 5 and C were more frequent in female and maTe mice, respectively. In both El aral E2, the biggest tumors (>600 mm3) were mainly high-grade 5 (87.5%-80%). Dietary fat and soy protein appear to influence the tumor  histopathology and thus its prognosis.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/25948
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first_indexed 2024-09-03T21:01:18Z
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