Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018).
Paracetamol (Acetaminophen) is an over-the-counter drug, present in most homes, becoming the leading cause of drug poisoning (accidental or voluntary) and acute liver failure in the world. Due to the frequency of presentation in pediatric emergency rooms and high morbidity and mortality of acute poi...
Guardado en:
| Autores principales: | , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25880 |
| Aporte de: |
| id |
I10-R327-article-25880 |
|---|---|
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
paracetamol / acetaminophen acute poisoning / paracetamol N-acetylcysteine paracetamol/acetaminofén intoxicación aguda/paracetamol N-acetilcisteína |
| spellingShingle |
paracetamol / acetaminophen acute poisoning / paracetamol N-acetylcysteine paracetamol/acetaminofén intoxicación aguda/paracetamol N-acetilcisteína Charcos, LC Llebeili, R Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| topic_facet |
paracetamol / acetaminophen acute poisoning / paracetamol N-acetylcysteine paracetamol/acetaminofén intoxicación aguda/paracetamol N-acetilcisteína |
| author |
Charcos, LC Llebeili, R |
| author_facet |
Charcos, LC Llebeili, R |
| author_sort |
Charcos, LC |
| title |
Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| title_short |
Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| title_full |
Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| title_fullStr |
Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| title_full_unstemmed |
Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). |
| title_sort |
characterization of patients with acute intoxication by paracetamol attended in the children's hospital santísima trinidad of córdoba (2008-2018). |
| description |
Paracetamol (Acetaminophen) is an over-the-counter drug, present in most homes, becoming the leading cause of drug poisoning (accidental or voluntary) and acute liver failure in the world. Due to the frequency of presentation in pediatric emergency rooms and high morbidity and mortality of acute poisoning with Paracetamol, we set out to carry out this work.
To describe prevalence, toxic-epidemiological aspects and the clinical assistance of acute poisoning with Paracetamol in the Children's Hospital of Córdoba / HNC (2008-2018).
Observational, descriptive and retrospective study. From the records of the HNC Toxicology Service, were included children under 15 years of age that were diagnosed with acute paracetamol poisoning (2008-2018). Demographic, clinical and epidemiological variables were described. The numerical data were summarized using measures of central tendency and dispersion, and categorical data by frequency distribution and percentages (95% CI).
Final sample included 62 patients, all the poisonings occurred at home, predominantly in children under 5 years: 38/62 (61%), frequent "accidental" cause and adolescents: 22/62 (35.5%) prevalent cause the "suicide attempt". There was association with other drugs in 32 patients (51.6%) either by commercial formulas or by poly-drug intake. The majority did not show symptoms at the time of the consultation. Digestive decontamination was performed; only 30/62 (48%) blood acetaminophen dosage was required to decide therapeutic behaviors according to the Rumack-Matthew nomogram; 10 of them needed treatment with N-acetylcysteine. Only 18/62 required hospitalization for follow-up. No comorbidities or mortality were reported in any case.
Acute paracetamol poisoning continues to be frequent in our environment mainly in children under 5 years old (accidental cause) and in adolescents in a situation of self-harm. Commercial formulas with two or more drugs, free access of medicines in homes, irresponsible use, self-medication, as well as the lack of controls on their sale are the main factors associated with poisoning. It would be important to raise public awareness as well as deepen public health measures for the prevention and regulation of access and consumption of these substances. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/25880 |
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2024-09-03T21:01:14Z |
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I10-R327-article-258802024-08-27T18:26:32Z Characterization of patients with acute intoxication by paracetamol attended in the Children's Hospital Santísima Trinidad of Córdoba (2008-2018). Caracterización de pacientes con intoxicación aguda por paracetamol atendidos en el Hospital de Niños de la Santísima Trinidad de Córdoba (2008-2018). Charcos, LC Llebeili, R paracetamol / acetaminophen acute poisoning / paracetamol N-acetylcysteine paracetamol/acetaminofén intoxicación aguda/paracetamol N-acetilcisteína Paracetamol (Acetaminophen) is an over-the-counter drug, present in most homes, becoming the leading cause of drug poisoning (accidental or voluntary) and acute liver failure in the world. Due to the frequency of presentation in pediatric emergency rooms and high morbidity and mortality of acute poisoning with Paracetamol, we set out to carry out this work. To describe prevalence, toxic-epidemiological aspects and the clinical assistance of acute poisoning with Paracetamol in the Children's Hospital of Córdoba / HNC (2008-2018). Observational, descriptive and retrospective study. From the records of the HNC Toxicology Service, were included children under 15 years of age that were diagnosed with acute paracetamol poisoning (2008-2018). Demographic, clinical and epidemiological variables were described. The numerical data were summarized using measures of central tendency and dispersion, and categorical data by frequency distribution and percentages (95% CI). Final sample included 62 patients, all the poisonings occurred at home, predominantly in children under 5 years: 38/62 (61%), frequent "accidental" cause and adolescents: 22/62 (35.5%) prevalent cause the "suicide attempt". There was association with other drugs in 32 patients (51.6%) either by commercial formulas or by poly-drug intake. The majority did not show symptoms at the time of the consultation. Digestive decontamination was performed; only 30/62 (48%) blood acetaminophen dosage was required to decide therapeutic behaviors according to the Rumack-Matthew nomogram; 10 of them needed treatment with N-acetylcysteine. Only 18/62 required hospitalization for follow-up. No comorbidities or mortality were reported in any case. Acute paracetamol poisoning continues to be frequent in our environment mainly in children under 5 years old (accidental cause) and in adolescents in a situation of self-harm. Commercial formulas with two or more drugs, free access of medicines in homes, irresponsible use, self-medication, as well as the lack of controls on their sale are the main factors associated with poisoning. It would be important to raise public awareness as well as deepen public health measures for the prevention and regulation of access and consumption of these substances. El Paracetamol (Acetaminofén) es un fármaco de venta libre, presente en la mayoría de los hogares, convirtiéndose en la primera causa de intoxicación medicamentosa (accidental o voluntaria) y de insuficiencia hepática aguda en el mundo. Debido a la frecuencia de presentación en salas de urgencias pediátricas y alta morbi-mortalidad de la intoxicación aguda con Paracetamol, nos propusimos realizar este trabajo. El objetivo de este trabajo fue describir prevalencia, aspectos toxico-epidemiológicos y la asistencia clínica de la Intoxicación aguda con Paracetamol en el Hospital de Niños de Córdoba/HNC ( 2008-2018 ). Estudio observacional, descriptivo y retrospectivo. A partir de los registros del Servicio de Toxicología del HNC fueron incluidos menores de 15 años con diagnóstico de intoxicación aguda por Paracetamol (2008-2018). Se describieron variables demográficas, clínicas y epidemiológicas. Los datos numéricos se resumieron mediante medidas de tendencia central y dispersión, y las categóricas por distribución de frecuencia y porcentajes (IC 95%). Muestra final 62 pacientes, ocurriendo todas las intoxicaciones en el hogar, con predominio en menores de 5 años: 38/62 (61%), causa frecuente “accidental” y adolescentes: 22/62 (35,5%) causa prevalente el “Intento de suicidio”. Hubo asociación a otros fármacos en 32 pacientes (51,6%) ya sea por fórmulas comerciales o por ingesta poli medicamentosa. La mayoría no presento síntomas al momento de la consulta. Se realizó descontaminación digestiva; solo requirieron dosaje en sangre de acetaminofén 30/62 (48%) para decidir conductas terapéuticas de acuerdo con el nomograma de Rumack-Matthew; 10 de ellos necesitaron tratamiento con N-acetilcisteína. Solo 18/62 requirieron internación para seguimiento. No se informaron comorbilidades ni mortalidad en ningún caso. La intoxicación aguda por paracetamol continúa siendo frecuente en nuestro medio principalmente en menores de 5 años (causa accidental) y en adolescentes en situación de autoagresión. Las fórmulas comerciales con dos o más fármacos, el libre acceso de medicamentos en los hogares, el uso irresponsable, la automedicación, así como la falta de controles en su venta constituyen los principales factores asociados a la intoxicación. Sería importante la concientización a la población así como profundizar medidas de salud pública para la prevención y regulación del acceso y consumo de estas sustancias. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25880 Revista de la Facultad de Ciencias Médicas de Córdoba.; 2019: Suplemento JIC XX Revista de la Facultad de Ciencias Médicas de Córdoba; 2019: Suplemento JIC XX Revista da Faculdade de Ciências Médicas de Córdoba; 2019: Suplemento JIC XX 1853-0605 0014-6722 10.31053/1853.0605.v76.nSuplemento spa https://revistas.unc.edu.ar/index.php/med/article/view/25880/27704 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |