ORIGINS OF HEALTH AND DISEASE

To present a new area of knowledge, knowri as developmental origins of health and  disease, covering its concepts study methods and ethical considerations. Material and   methods: A review of the medical literature intended to identify current references related  to the subject under discussion.Resu...

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Autor principal: Cuestas, Eduardo
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Materias:
biología del desarrollo
hipótesis de barker
developmental biology
barker hypothesis
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25506
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-25506
record_format ojs
spelling I10-R327-article-255062024-08-27T18:25:49Z ORIGINS OF HEALTH AND DISEASE Orígenes de la Salud y la Enfermedad Cuestas, Eduardo biología del desarrollo hipótesis de barker developmental biology barker hypothesis To present a new area of knowledge, knowri as developmental origins of health and  disease, covering its concepts study methods and ethical considerations. Material and   methods: A review of the medical literature intended to identify current references related  to the subject under discussion.Results: The studies dernonstrate associations between aggressions suffered during the  initial phases of somatic development and amplified risk of chronic diseases throughout   life, such as obesity, diabetes and cardiovascular diseases. A variety of modeis havc been  proposed inattempts to better explain these associations,such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Mechanisms possihly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signais transmitted to the fetus via the placenta or the newborn vía lactation.Conclusions: Developmental origins of health and diseases draws together information originating from many different arcas of knowledge, proposing new investigative methodologies Lo clucidate the influence of adverse events that occur during early phases of human development on the pattern of health and disease throughout. life. This new scientiflc fleid proposes new modeis of causali' and of the mechanisms involved in the emergence aral development of chronic diseases. The results of these invcstigations may result in a signiflcant impaci on the prevention of chronic diseases, and also on health promotion in differentphases of life. Presentar un nuevo campo del conocimiento, que estudia los orígenes de la salud y la  enfermedad a través del desarrollo evolutivo del ser humano, abordando conceptos, métodos  e estudio, aspectos éticos y diferentes perspectivas referidas a ésta área del saber. Material y  métodos: Revisión de la literatura, para obtener referencias pertinentes y actualizadas  relacionadas con el tema. Resultados: Los estudios recientes demuestran asociaciones entre  eventos ocurridos en fases tempranas del desarrollo somático y el aumento del riesgo para presentar enfermedades crónicas a lo largo de la vida, tales como diabetes, obesidad y  enfermedades cardiovasculares. Se han propuesto diferentes modelos para explicar esas  asociaciones, como la teoría del fenotipo frugal, la programación, las respuestas adaptativas  predictivas y el concepto de concordancia o contraste. Algunos de los posibles mecanismos  involucrados en estos procesos son: efectos del ambiente sobre la expresión génica, a través  e mecanismos epigenéticos; efectos de señales hormonales transmitidos al feto a través de  a placenta o al neonato por la leche materna.  Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25506 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 64 No. 3 (2007); 73-86 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 64 Núm. 3 (2007); 73-86 Revista da Faculdade de Ciências Médicas de Córdoba; v. 64 n. 3 (2007); 73-86 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/25506/24734 Derechos de autor 1970 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic biología del desarrollo
hipótesis de barker
developmental biology
barker hypothesis
spellingShingle biología del desarrollo
hipótesis de barker
developmental biology
barker hypothesis
Cuestas, Eduardo
ORIGINS OF HEALTH AND DISEASE
topic_facet biología del desarrollo
hipótesis de barker
developmental biology
barker hypothesis
author Cuestas, Eduardo
author_facet Cuestas, Eduardo
author_sort Cuestas, Eduardo
title ORIGINS OF HEALTH AND DISEASE
title_short ORIGINS OF HEALTH AND DISEASE
title_full ORIGINS OF HEALTH AND DISEASE
title_fullStr ORIGINS OF HEALTH AND DISEASE
title_full_unstemmed ORIGINS OF HEALTH AND DISEASE
title_sort origins of health and disease
description To present a new area of knowledge, knowri as developmental origins of health and  disease, covering its concepts study methods and ethical considerations. Material and   methods: A review of the medical literature intended to identify current references related  to the subject under discussion.Results: The studies dernonstrate associations between aggressions suffered during the  initial phases of somatic development and amplified risk of chronic diseases throughout   life, such as obesity, diabetes and cardiovascular diseases. A variety of modeis havc been  proposed inattempts to better explain these associations,such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Mechanisms possihly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signais transmitted to the fetus via the placenta or the newborn vía lactation.Conclusions: Developmental origins of health and diseases draws together information originating from many different arcas of knowledge, proposing new investigative methodologies Lo clucidate the influence of adverse events that occur during early phases of human development on the pattern of health and disease throughout. life. This new scientiflc fleid proposes new modeis of causali' and of the mechanisms involved in the emergence aral development of chronic diseases. The results of these invcstigations may result in a signiflcant impaci on the prevention of chronic diseases, and also on health promotion in differentphases of life.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/25506
work_keys_str_mv AT cuestaseduardo originsofhealthanddisease
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first_indexed 2024-09-03T21:00:45Z
last_indexed 2024-09-03T21:00:45Z
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