Brain signaling mechanisms during neonatal sepsis

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The brain and the immune system are the two major adaptive systems of the body. During an immune response the developing neonatal brain and the immune system "cross-talk" and this course of action is essential for maintaining homeostasis. Two pathway are involved in this intercommunication...

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Autores principales: Cuestas, Eduardo, Rizzotti, Alina, Agüero, Guillermo
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2010
Materias:
neonatal sepsis
brain
immune system
sepsis neonatal
cerebro
sistema inmune
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/22631
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-22631
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic neonatal sepsis
brain
immune system
sepsis neonatal
cerebro
sistema inmune
spellingShingle neonatal sepsis
brain
immune system
sepsis neonatal
cerebro
sistema inmune
Cuestas, Eduardo
Rizzotti, Alina
Agüero, Guillermo
Brain signaling mechanisms during neonatal sepsis
topic_facet neonatal sepsis
brain
immune system
sepsis neonatal
cerebro
sistema inmune
author Cuestas, Eduardo
Rizzotti, Alina
Agüero, Guillermo
author_facet Cuestas, Eduardo
Rizzotti, Alina
Agüero, Guillermo
author_sort Cuestas, Eduardo
title Brain signaling mechanisms during neonatal sepsis
title_short Brain signaling mechanisms during neonatal sepsis
title_full Brain signaling mechanisms during neonatal sepsis
title_fullStr Brain signaling mechanisms during neonatal sepsis
title_full_unstemmed Brain signaling mechanisms during neonatal sepsis
title_sort brain signaling mechanisms during neonatal sepsis
description The brain and the immune system are the two major adaptive systems of the body. During an immune response the developing neonatal brain and the immune system "cross-talk" and this course of action is essential for maintaining homeostasis. Two pathway are involved in this intercommunication: the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Thisless attention than the role of HPA axis. Evidence suggests that norepinephrine (NE) is a neurotransmitter/ neuromodulator in different organs and tissues. Under stimulation, NE is released from the sympathetic nerve terminals in these organs and tissues .Through stimulation of specific receptors, locally released NE, or circulating catecholamines such as epinephrine, affect lymphocyte traffic, circulation, and proliferation, and modulate cytokine production and the functional activity of different lymphoid cells. In addition, recent evidence is discussed that NE and epinephrine, through stimulation of the beta(2)-adrenoreceptor-cAMP-protein kinase A pathway, inhibit the production of type 1/proinflammatory cytokines, such as interleukin (IL-12), tumor necrosis factor-alpha, and interferongamma by antigen-presenting cells and T helper (Th) 1 cells, whereas they stimulate the production of type 2/anti-inflammatory cytokines such as IL-10 and transforming growth factor-beta. Thus, the activation of SNS during an immune response might be aimed to localize the inflammatory response.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2010
url https://revistas.unc.edu.ar/index.php/med/article/view/22631
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AT rizzottialina brainsignalingmechanismsduringneonatalsepsis
AT agueroguillermo brainsignalingmechanismsduringneonatalsepsis
AT cuestaseduardo mecanismosdesenalizacioncerebraldurantelasepsisneonatal
AT rizzottialina mecanismosdesenalizacioncerebraldurantelasepsisneonatal
AT agueroguillermo mecanismosdesenalizacioncerebraldurantelasepsisneonatal
first_indexed 2024-09-03T21:00:25Z
last_indexed 2024-09-03T21:00:25Z
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spelling I10-R327-article-226312024-08-27T18:24:08Z Brain signaling mechanisms during neonatal sepsis Mecanismos de señalización cerebral durante la sepsis neonatal Cuestas, Eduardo Rizzotti, Alina Agüero, Guillermo neonatal sepsis brain immune system sepsis neonatal cerebro sistema inmune The brain and the immune system are the two major adaptive systems of the body. During an immune response the developing neonatal brain and the immune system "cross-talk" and this course of action is essential for maintaining homeostasis. Two pathway are involved in this intercommunication: the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Thisless attention than the role of HPA axis. Evidence suggests that norepinephrine (NE) is a neurotransmitter/ neuromodulator in different organs and tissues. Under stimulation, NE is released from the sympathetic nerve terminals in these organs and tissues .Through stimulation of specific receptors, locally released NE, or circulating catecholamines such as epinephrine, affect lymphocyte traffic, circulation, and proliferation, and modulate cytokine production and the functional activity of different lymphoid cells. In addition, recent evidence is discussed that NE and epinephrine, through stimulation of the beta(2)-adrenoreceptor-cAMP-protein kinase A pathway, inhibit the production of type 1/proinflammatory cytokines, such as interleukin (IL-12), tumor necrosis factor-alpha, and interferongamma by antigen-presenting cells and T helper (Th) 1 cells, whereas they stimulate the production of type 2/anti-inflammatory cytokines such as IL-10 and transforming growth factor-beta. Thus, the activation of SNS during an immune response might be aimed to localize the inflammatory response. El cerebro y el sistema inmune son los dos principales sistemas de adaptación del ser humano. Durante una respuesta inmune se establece una intercomunicación entre el cerebro neonatal y el sistema inmunológico en desarrollo, y este curso de acción es esencial para mantener la homeostasis. Dos vías están principalmente involucradas en esta intercomunicación: el eje hipotálamo-pituitarioadrenal (HPA) y el sistema nervioso simpático (SNS). Esta revisión trata el papel del SNS en las interacciones neuroinmunes, centrándose especialmente sobre la función del eje HPA. La evidencia sugiere que la norepinefrina (NE) es un neurotransmisor/ neuromodulador en diferentes órganos y tejidos. Bajo determinados estímulos, se libera NE de las terminales nerviosas simpáticas, a través de la activación de receptores específicos, liberadas localmente o a la circulación, las catecolaminas, afectan el tráfico, la circulación y proliferación de los linfocitos, y modulan la producción de citoquinas. Además existe evidencia reciente de que la NE y la epinefrina, a través de la estimulación de la vía beta (2)-adrenérgico-AMPc-proteína quinasa A, inhiben la producción de citocinas tipo 1/proinflamatorias, tales como la interleuquina (IL-12), factor de necrosis tumoral alfa e interferón gamma por células presentadoras de antígeno y linfocitos T helper (Th) 1 en las células, mientras que estimulan la producción de citocinas tipo 2/antinflammatorias como la IL-10 y factor de crecimiento transformante beta. Por lo tanto, la activación del SNS durante una respuesta inmune podría actuar como un “localizar” de la respuesta inflamatoria. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2010-09-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/22631 10.31053/1853.0605.v67.n3.22631 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 67 No. 3 (2010); 108-111 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 67 Núm. 3 (2010); 108-111 Revista da Faculdade de Ciências Médicas de Córdoba; v. 67 n. 3 (2010); 108-111 1853-0605 0014-6722 10.31053/1853.0605.v67.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/22631/22248 Derechos de autor 2010 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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