The induced sputum allows guide a therapeutic strategy to control bronchial asthma
In spite of physiopathogenic and therapeutic advances, asthma remains uncontrolled. The purpose of this test is to assess whether the instruments commonly used in the management of asthma are sufficient tools to control asthma, comparing the information provided by clinical evidence with cellular i...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2010
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/22577 |
| Aporte de: |
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I10-R327-article-22577 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
asma control del asma esputo inducido estrategia guiada por esputo inducido asthma control induced sputum strategy guided by induced putum |
| spellingShingle |
asma control del asma esputo inducido estrategia guiada por esputo inducido asthma control induced sputum strategy guided by induced putum Uribe Echevarría, Elisa Margarita Garcia, Luciana Leimgruber, Carolina Quintar, Amado Uribe Echevarría, Agustín M. Maldonado, Cristina The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| topic_facet |
asma control del asma esputo inducido estrategia guiada por esputo inducido asthma control induced sputum strategy guided by induced putum |
| author |
Uribe Echevarría, Elisa Margarita Garcia, Luciana Leimgruber, Carolina Quintar, Amado Uribe Echevarría, Agustín M. Maldonado, Cristina |
| author_facet |
Uribe Echevarría, Elisa Margarita Garcia, Luciana Leimgruber, Carolina Quintar, Amado Uribe Echevarría, Agustín M. Maldonado, Cristina |
| author_sort |
Uribe Echevarría, Elisa Margarita |
| title |
The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| title_short |
The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| title_full |
The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| title_fullStr |
The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| title_full_unstemmed |
The induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| title_sort |
induced sputum allows guide a therapeutic strategy to control bronchial asthma |
| description |
In spite of physiopathogenic and therapeutic advances, asthma remains uncontrolled. The purpose of this test is to assess whether the instruments commonly used in the management of asthma are sufficient tools to control asthma, comparing the information provided by clinical evidence with cellular inflammatory parameters obtained through the analysis of induced sputum.We studied 15 asthmatics under treatment, which were evaluated the asthma control status (ACS) by clinical and spirometrical criteria, according to GINA recommendations. Then each patient underwent to obtain a sample of induced sputum (IE) and it was further analysed as a previously validated tech nique. From the total number of patients, 7 were total controlled patients according to ACS; only 2 of them had a normal IE cellular pattern while the other 5 presented an inflammatory profile in the differential cells count of the IE, forced to make adjustments in the anti-inflammatory treatment. One partially controlled patient by ACS, revealed inflammatory parameters in IE allowing modify the therapeutic schema. In 7 not controlled patients by ACS, the cellular inflammatory characteristics in IE, allowed modify therapeutic strategy which achieved control of the disease.We concluded that inflamommetry by IE cellular analysis is the tool that contributes to optimize the treatment and achieve true control of the disease.We suggest including this procedure in clinical practice and proposing a strategy for the management of asthma. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2010 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/22577 |
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I10-R327-article-225772024-08-27T18:24:06Z The induced sputum allows guide a therapeutic strategy to control bronchial asthma El esputo inducido permite guiar una estrategia terapéutica para lograr el control del asma bronquial Uribe Echevarría, Elisa Margarita Garcia, Luciana Leimgruber, Carolina Quintar, Amado Uribe Echevarría, Agustín M. Maldonado, Cristina asma control del asma esputo inducido estrategia guiada por esputo inducido asthma control induced sputum strategy guided by induced putum In spite of physiopathogenic and therapeutic advances, asthma remains uncontrolled. The purpose of this test is to assess whether the instruments commonly used in the management of asthma are sufficient tools to control asthma, comparing the information provided by clinical evidence with cellular inflammatory parameters obtained through the analysis of induced sputum.We studied 15 asthmatics under treatment, which were evaluated the asthma control status (ACS) by clinical and spirometrical criteria, according to GINA recommendations. Then each patient underwent to obtain a sample of induced sputum (IE) and it was further analysed as a previously validated tech nique. From the total number of patients, 7 were total controlled patients according to ACS; only 2 of them had a normal IE cellular pattern while the other 5 presented an inflammatory profile in the differential cells count of the IE, forced to make adjustments in the anti-inflammatory treatment. One partially controlled patient by ACS, revealed inflammatory parameters in IE allowing modify the therapeutic schema. In 7 not controlled patients by ACS, the cellular inflammatory characteristics in IE, allowed modify therapeutic strategy which achieved control of the disease.We concluded that inflamommetry by IE cellular analysis is the tool that contributes to optimize the treatment and achieve true control of the disease.We suggest including this procedure in clinical practice and proposing a strategy for the management of asthma. A pesar de los avances fisiopatogénicos y terapéuticos, el asma permanece sin control.El objetivo de este ensayo es mostrar evidencias clínicas-científicas que los instrumentos utilizados en el manejo del asma no son herramientas suficientes y proponer una estrategia para el abordaje y su control en forma objetiva, teniendo como blanco terapéutico la inflamación de la vía aérea según parámetros celulares del esputo inducido. Evaluamos en 15 pacientes asmáticos bajo tratamiento: el grado de control del asma (GCA) en base a criterios clínicos, espirométricos y el cuestionario de control, según recomendaciones de GINA (Global Initiative for Asthma). Posteriormente todos los pacientes fueron sometidos a la recolección de una muestra de esputo inducido (EI) para realizar el recuento diferencial de células según técnica previamente validada.Del total estudiados, obtuvimos que 7 pacientes, a pesar que se encontraban totalmente controlados según parámetros de GCA 5 presentaban un perfil inflamatorio en el recuento diferencial de células del EI que obligaron a ajustar las dosis del tratamiento antiinflamatorio. Un paciente parcialmente controlado según GCA, reveló parámetros inflamatorios en EI y se le modificó el tratamiento. En 7 pacientes no controlados según GCA, las características de las células inflamatorias en el EI permitieron modificar la estrategia terapéutica con lo que se logró controlar la enfermedad.Concluimos que la inflamometría por medio del análisis celular del EI es la herramienta más apropiada para optimizar el tratamiento y alcanzar el verdadero control de la enfermedad. Aconsejamos incluir este procedimiento en la práctica clínica y sugerimos una estrategia para el manejo del asma bronquial. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2010-12-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/22577 10.31053/1853.0605.v67.n4.22577 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 67 No. 4 (2010); 169-176 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 67 Núm. 4 (2010); 169-176 Revista da Faculdade de Ciências Médicas de Córdoba; v. 67 n. 4 (2010); 169-176 1853-0605 0014-6722 10.31053/1853.0605.v67.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/22577/22192 Derechos de autor 2010 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |