Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept

Introduction: There are numerous reports of patients with rheumatoid arthritis (RA) who became pregnant while on treatment with etanercept. In spite of being formally contraindicated during pregnancy and lactation its discontinuation in cases of women with severe RA is no longer recommended since an...

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Autores principales: Malano, Damian Jesus, Strusberg, Ingrid
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Materias:
etanercept
in vitro fertilization
rheumatoid arthritis
fertilizacion in vitro
artritis reumatoide
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/21959
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-21959
record_format ojs
spelling I10-R327-article-219592024-08-27T18:23:58Z Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept Embarazos a término por fertilización asistida en dos pacientes con artritis reumatoidea severa en tratamiento con etanercept Malano, Damian Jesus Strusberg, Ingrid etanercept in vitro fertilization rheumatoid arthritis etanercept fertilizacion in vitro artritis reumatoide Introduction: There are numerous reports of patients with rheumatoid arthritis (RA) who became pregnant while on treatment with etanercept. In spite of being formally contraindicated during pregnancy and lactation its discontinuation in cases of women with severe RA is no longer recommended since an increase in congenital malformations nor perinatal complications has not been reported. There are few data on the success or failure of pregnancies achieved by assisted fertilization in patients with RA treated with etanercept. Methods: Two cases of severe RA under etanercept treatment and assisted fertilization are described. Results: After 4 failed attempts both patients became pregnant. They finally arrived at term without obstetric or perinatal complications. No congenital malformations nor infectious complications of the newborns occurred. Conclusion: The risk-benefit profile of etanercept in severe RA patients has been changing with postmarketing surveillance. If there is clinical indication, the benefit of not stopping etanercept during assited fertilization and pregnancy should be evaluated. Introducción: Existen numerosos reportes de pacientes con artritis reumatoidea (AR) que quedaron embarazadas mientras se encontraban en tratamiento con etanercept. Si bien se encuentra formalmente contraindicado durante embarazo y lactancia, su suspensión en casos de mujeres con AR severa ya no se aconseja debido a que no se ha reportado un aumento de malformaciones congénitas ni de complicaciones perinatales. Existen pocos datos acerca del éxito o fracaso de embarazos logrados por fertilización asistida en pacientes con AR en tratamiento con etanercept. Métodos: Se describen dos casos clínicos de pacientes con AR severa en tratamiento con etanercept que realizaron técnicas de fertilización in vitro. Resultados: Tras 4 intentos fallidos, ambas pacientes cursaron embarazos sin complicaciones obstétricas ni perinatales y no se registraron malformaciones congénitas ni complicaciones infectológicas en los recién nacidos. Conclusión: El perfil riesgo-beneficio de etanercept en pacientes con AR severa ha ido cambiando con la farmacovigilancia poscomercialización. Si existe indicación clínica, debe evaluarse el beneficio de no suspenderlo en el curso de tratamientos de fertilización asistida y embarazo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-02-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html application/vnd.openxmlformats-officedocument.wordprocessingml.document https://revistas.unc.edu.ar/index.php/med/article/view/21959 10.31053/1853.0605.v76.n1.21959 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 76 No. 1 (2019); 59-62 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 76 Núm. 1 (2019); 59-62 Revista da Faculdade de Ciências Médicas de Córdoba; v. 76 n. 1 (2019); 59-62 1853-0605 0014-6722 10.31053/1853.0605.v76.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/21959/23340 https://revistas.unc.edu.ar/index.php/med/article/view/21959/23287 https://revistas.unc.edu.ar/index.php/med/article/view/21959/27110 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic etanercept
in vitro fertilization
rheumatoid arthritis
etanercept
fertilizacion in vitro
artritis reumatoide
spellingShingle etanercept
in vitro fertilization
rheumatoid arthritis
etanercept
fertilizacion in vitro
artritis reumatoide
Malano, Damian Jesus
Strusberg, Ingrid
Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
topic_facet etanercept
in vitro fertilization
rheumatoid arthritis
etanercept
fertilizacion in vitro
artritis reumatoide
author Malano, Damian Jesus
Strusberg, Ingrid
author_facet Malano, Damian Jesus
Strusberg, Ingrid
author_sort Malano, Damian Jesus
title Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
title_short Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
title_full Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
title_fullStr Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
title_full_unstemmed Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
title_sort assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept
description Introduction: There are numerous reports of patients with rheumatoid arthritis (RA) who became pregnant while on treatment with etanercept. In spite of being formally contraindicated during pregnancy and lactation its discontinuation in cases of women with severe RA is no longer recommended since an increase in congenital malformations nor perinatal complications has not been reported. There are few data on the success or failure of pregnancies achieved by assisted fertilization in patients with RA treated with etanercept. Methods: Two cases of severe RA under etanercept treatment and assisted fertilization are described. Results: After 4 failed attempts both patients became pregnant. They finally arrived at term without obstetric or perinatal complications. No congenital malformations nor infectious complications of the newborns occurred. Conclusion: The risk-benefit profile of etanercept in severe RA patients has been changing with postmarketing surveillance. If there is clinical indication, the benefit of not stopping etanercept during assited fertilization and pregnancy should be evaluated.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/21959
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AT strusbergingrid assistedfertilizationwithattermpregnanciesintwopatientswithsevererheumatoidarthritiswhileintreatmentwithetanercept
AT malanodamianjesus embarazosaterminoporfertilizacionasistidaendospacientesconartritisreumatoideaseveraentratamientoconetanercept
AT strusbergingrid embarazosaterminoporfertilizacionasistidaendospacientesconartritisreumatoideaseveraentratamientoconetanercept
first_indexed 2024-09-03T21:00:21Z
last_indexed 2024-09-03T21:00:21Z
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