Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children

Objectives: To determine whether changes related to age in gastroesophageal reflux (GER) in infants and children are due to acid, non acid reflux or both, as determined by 24 hr pH probe (pH) and Multichannel Intraluminal Impedance (MII).Methods: Tracings of simultaneous pH-MII from 243 infants and...

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Autores principales: Orsi, Marina, Cohen-Sabban, Judith, Grandi, Carlos, Donato, María Gabriela, Lifschitz, Carlos, D’Agostino, Daniel
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2011
Materias:
gastroesophageal reflux
multichannel intraluminal impedance
non acid reflux
pH probe
reflujo gastroesofágico
impedancia intraluminal multicanal
niños
reflujo no ácido
pHmetría
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/21574
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-21574
record_format ojs
spelling I10-R327-article-215742024-08-27T18:23:43Z Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children Disminucion con la edad de los episodios de reflujo gastroesofagico no acido determinados por impedancia intraluminal multicanal y phmetria en niños sintomaticos Orsi, Marina Cohen-Sabban, Judith Grandi, Carlos Donato, María Gabriela Lifschitz, Carlos D’Agostino, Daniel gastroesophageal reflux multichannel intraluminal impedance non acid reflux pH probe reflujo gastroesofágico impedancia intraluminal multicanal niños reflujo no ácido pHmetría Objectives: To determine whether changes related to age in gastroesophageal reflux (GER) in infants and children are due to acid, non acid reflux or both, as determined by 24 hr pH probe (pH) and Multichannel Intraluminal Impedance (MII).Methods: Tracings of simultaneous pH-MII from 243 infants and children who presented with either digestive or respiratory symptoms attributable to GER were reviewed and analyzed using Mann-Whitney U test.Results: The number of GER episodes recorded was similar among children with predominantly gastrointestinal and those with respiratory symptoms. A significantly higher total number of GER episodes was observed by pH probe and MII in children under 22.8 mos of age compared with those who were older (median 159 vs. 110.5, p = 0.002). There was no significant change with age of acid reflux (AR) parameters. The changes observed were due to the significant decrease of non AR for all parameters measured, regardless of the presenting symptom.Conclusions: The decrease in GER parameters that is observed after a mean of 22.8 mos. of age is at the expense of non AR. This finding may have an impact on the choice and results of therapeutic modalities in children versus that in infants. Objetivos: Determinar si los cambios de reflujo gastroesofágico (RGE) relacionados a la edad en pacientes pediátricos sintomáticos, medidos por Impedanciometría Intraluminal Multicanal (IIM).y pHmetría de 24 horas (pH), se deben a reflujo ácido, no ácido o ambos.Métodos: Se revisaron y analizaron usando la prueba de Mann-Whitney U trazados simultáneos de IIM-pH de 243 niños que presentaron con síntomas digestivos o respiratorios atribuibles a RGE. Results: El número de episodios registrados de RGE fue semejante en niños con síntomas predominantemente gastrointestinales que en aquellos con síntomas respiratorios. Se observó un número significativamente más grande de RGE por pH e IIM en niños debajo de los 22.8 meses de edad comparado con los mayores de esa edad (media 159 vs. 110.5, p = 0.002). No hubo un cambio significativo con la edad en los parámetros relacionados a reflujo acido (RA). Los cambios observados se debieron a una disminución significativa del reflujo no ácido en todos los parámetros estudiados, independientemente de los síntomas de presentación. Conclusiones: La disminución en los parámetros de RGE que se observan con la edad después de una media de 22.8 meses de edad se hace a expensas del reflujo no ácido. Esto puede tener un impacto en la elección y resultado de las modalidades terapéuticas en niños mayores versus los más pequeños.  Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2011-02-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/21574 10.31053/1853.0605.v68.n1.21574 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 68 No. 1 (2011); 8-13 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 68 Núm. 1 (2011); 8-13 Revista da Faculdade de Ciências Médicas de Córdoba; v. 68 n. 1 (2011); 8-13 1853-0605 0014-6722 10.31053/1853.0605.v68.n1 eng https://revistas.unc.edu.ar/index.php/med/article/view/21574/21323 Derechos de autor 2011 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Inglés
format Artículo revista
topic gastroesophageal reflux
multichannel intraluminal impedance
non acid reflux
pH probe
reflujo gastroesofágico
impedancia intraluminal multicanal
niños
reflujo no ácido
pHmetría
spellingShingle gastroesophageal reflux
multichannel intraluminal impedance
non acid reflux
pH probe
reflujo gastroesofágico
impedancia intraluminal multicanal
niños
reflujo no ácido
pHmetría
Orsi, Marina
Cohen-Sabban, Judith
Grandi, Carlos
Donato, María Gabriela
Lifschitz, Carlos
D’Agostino, Daniel
Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
topic_facet gastroesophageal reflux
multichannel intraluminal impedance
non acid reflux
pH probe
reflujo gastroesofágico
impedancia intraluminal multicanal
niños
reflujo no ácido
pHmetría
author Orsi, Marina
Cohen-Sabban, Judith
Grandi, Carlos
Donato, María Gabriela
Lifschitz, Carlos
D’Agostino, Daniel
author_facet Orsi, Marina
Cohen-Sabban, Judith
Grandi, Carlos
Donato, María Gabriela
Lifschitz, Carlos
D’Agostino, Daniel
author_sort Orsi, Marina
title Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
title_short Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
title_full Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
title_fullStr Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
title_full_unstemmed Non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
title_sort non acid gastroesophageal reflux episodes decrease with age as determined by multichannel intraluminal impedance-ph monitoring in symptomatic children
description Objectives: To determine whether changes related to age in gastroesophageal reflux (GER) in infants and children are due to acid, non acid reflux or both, as determined by 24 hr pH probe (pH) and Multichannel Intraluminal Impedance (MII).Methods: Tracings of simultaneous pH-MII from 243 infants and children who presented with either digestive or respiratory symptoms attributable to GER were reviewed and analyzed using Mann-Whitney U test.Results: The number of GER episodes recorded was similar among children with predominantly gastrointestinal and those with respiratory symptoms. A significantly higher total number of GER episodes was observed by pH probe and MII in children under 22.8 mos of age compared with those who were older (median 159 vs. 110.5, p = 0.002). There was no significant change with age of acid reflux (AR) parameters. The changes observed were due to the significant decrease of non AR for all parameters measured, regardless of the presenting symptom.Conclusions: The decrease in GER parameters that is observed after a mean of 22.8 mos. of age is at the expense of non AR. This finding may have an impact on the choice and results of therapeutic modalities in children versus that in infants.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2011
url https://revistas.unc.edu.ar/index.php/med/article/view/21574
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first_indexed 2024-09-03T21:00:18Z
last_indexed 2024-09-03T21:00:18Z
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