Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation
Background: Atrial fibrillation is the most common cardiac tachyarrythmia and is an important independent risk factor for ischemic stroke. Its prevalence begins to increase in both sexes after 40 years of age as well as the risk of hemorrhage. The aim of this study was to compare the annual rate of...
| Autores principales: | , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2011
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/21509 |
| Aporte de: |
| id |
I10-R327-article-21509 |
|---|---|
| record_format |
ojs |
| spelling |
I10-R327-article-215092024-08-27T18:23:34Z Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation Riesco de hemorragia en pacientes mayores de 85 años anticoagulados por fibrilación auricular Revigliono, José I. Amuchastegui, Tomás Contreras, Alejandro E. Amuchastegui, Marcos atrial fibrillation anticoagulation hemorrhage major bleeding fibrilación auricular anticoagulación hemorragia sangrado mayor Background: Atrial fibrillation is the most common cardiac tachyarrythmia and is an important independent risk factor for ischemic stroke. Its prevalence begins to increase in both sexes after 40 years of age as well as the risk of hemorrhage. The aim of this study was to compare the annual rate of hemorrhagic events between patients older and younger than 85 years, with diagnosis of nonvalvular atrial fibrillation and anticoagulated with warfarin. Material and methods: A retrospective study was performed. We included 118 patients with diagnosis of nonvalvular atrial fibrillation monitorized by an informatized follow up system. Results: The study follow-up was 28,2 ±17,5 months and 24 patients (20,3%) were older than 85 years of age. The rate of major bleedings was 4,62%/year (older than 85 years) vs 0,95%/year (younger than 85 years) , p= 0,05, OR 6,57 (IC 95% 1,04-41,8) and minor bleeding was 4,62%/year (older than 85 years) vs 5,2%/year (younger than 85 years), p=0,99, OR 1,08 (IC 95% 0,28-4,21). There was no difference in the Time in Therapeutic Range between both groups (56.4 ± 16.3 % vs 60.5 ± 17.7 %, p 0,30). Conclusion: The age should not be considered a contraindication to anticoagulant therapy, however, special care and careful monitoring of patients older than 85 years should be considered due to they had high risk of bleeding. Antecedentes: La fibrilación auricular es la más común de las taquiarritmias y es un importante factor de riesgo independiente para accidente cerebrovascular. Su prevalencia comienza a incrementarse en ambos sexos después de los 40 años de edad así como el riesgo de hemorragia. El objetivo de este trabajo fue, comparar la tasa anual de eventos hemorrágicos entre pacientes mayores y menores de 85 años de edad, con diagnóstico de fibrilación auricular no valvular y anticoagulados con warfarina.Material y métodos: Se realizó un estudio retrospectivo, dónde se incluyeron 118 pacientes con diagnóstico de fibrilación auricular no valvular monitorizado por sistema informático de anticoagulación. Resultados: El estudio tuvo un seguimiento de 28,2 ±17,5 meses, 24 pacientes (20,3%) tenían más de 85 años de edad. El porcentaje de sangrados mayores fue 4,62%/anual (? a 85 años) vs 0,95%/anual (< a 85 años); p= 0,05, OR 6,57 (IC 95% 1,04-41,8) y de sangrados menores 4,62%/anual (? a 85 años) vs 5,2%/anual (< a 85 años), p=0,99; OR 1,08 (IC 95% 0,28-4,21). No hubo diferencias en el Tiempo en Rango Terapéutico entre ambos grupos (56,4 ± 16,3% vs 60,5 ± 17,7%, p=0,30). Conclusión: la edad no debería ser un motivo suficiente para contraindicar la anticoagulación, sin embargo, se debe tener especial cuidado y un seguimiento estricto de los pacientes mayores de 85 años de edad, ya que poseen mayor riesgo de sangrados. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2011-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/21509 10.31053/1853.0605.v68.n3.21509 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 68 No. 3 (2011); 94-100 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 68 Núm. 3 (2011); 94-100 Revista da Faculdade de Ciências Médicas de Córdoba; v. 68 n. 3 (2011); 94-100 1853-0605 0014-6722 10.31053/1853.0605.v68.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/21509/21165 Derechos de autor 2011 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
atrial fibrillation anticoagulation hemorrhage major bleeding fibrilación auricular anticoagulación hemorragia sangrado mayor |
| spellingShingle |
atrial fibrillation anticoagulation hemorrhage major bleeding fibrilación auricular anticoagulación hemorragia sangrado mayor Revigliono, José I. Amuchastegui, Tomás Contreras, Alejandro E. Amuchastegui, Marcos Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| topic_facet |
atrial fibrillation anticoagulation hemorrhage major bleeding fibrilación auricular anticoagulación hemorragia sangrado mayor |
| author |
Revigliono, José I. Amuchastegui, Tomás Contreras, Alejandro E. Amuchastegui, Marcos |
| author_facet |
Revigliono, José I. Amuchastegui, Tomás Contreras, Alejandro E. Amuchastegui, Marcos |
| author_sort |
Revigliono, José I. |
| title |
Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| title_short |
Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| title_full |
Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| title_fullStr |
Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| title_full_unstemmed |
Risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| title_sort |
risc of hemorrhage in patients older than 85 years, anticoagulated due to atrial fibrillation |
| description |
Background: Atrial fibrillation is the most common cardiac tachyarrythmia and is an important independent risk factor for ischemic stroke. Its prevalence begins to increase in both sexes after 40 years of age as well as the risk of hemorrhage. The aim of this study was to compare the annual rate of hemorrhagic events between patients older and younger than 85 years, with diagnosis of nonvalvular atrial fibrillation and anticoagulated with warfarin. Material and methods: A retrospective study was performed. We included 118 patients with diagnosis of nonvalvular atrial fibrillation monitorized by an informatized follow up system. Results: The study follow-up was 28,2 ±17,5 months and 24 patients (20,3%) were older than 85 years of age. The rate of major bleedings was 4,62%/year (older than 85 years) vs 0,95%/year (younger than 85 years) , p= 0,05, OR 6,57 (IC 95% 1,04-41,8) and minor bleeding was 4,62%/year (older than 85 years) vs 5,2%/year (younger than 85 years), p=0,99, OR 1,08 (IC 95% 0,28-4,21). There was no difference in the Time in Therapeutic Range between both groups (56.4 ± 16.3 % vs 60.5 ± 17.7 %, p 0,30). Conclusion: The age should not be considered a contraindication to anticoagulant therapy, however, special care and careful monitoring of patients older than 85 years should be considered due to they had high risk of bleeding. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2011 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/21509 |
| work_keys_str_mv |
AT reviglionojosei riscofhemorrhageinpatientsolderthan85yearsanticoagulatedduetoatrialfibrillation AT amuchasteguitomas riscofhemorrhageinpatientsolderthan85yearsanticoagulatedduetoatrialfibrillation AT contrerasalejandroe riscofhemorrhageinpatientsolderthan85yearsanticoagulatedduetoatrialfibrillation AT amuchasteguimarcos riscofhemorrhageinpatientsolderthan85yearsanticoagulatedduetoatrialfibrillation AT reviglionojosei riescodehemorragiaenpacientesmayoresde85anosanticoaguladosporfibrilacionauricular AT amuchasteguitomas riescodehemorragiaenpacientesmayoresde85anosanticoaguladosporfibrilacionauricular AT contrerasalejandroe riescodehemorragiaenpacientesmayoresde85anosanticoaguladosporfibrilacionauricular AT amuchasteguimarcos riescodehemorragiaenpacientesmayoresde85anosanticoaguladosporfibrilacionauricular |
| first_indexed |
2024-09-03T21:00:14Z |
| last_indexed |
2024-09-03T21:00:14Z |
| _version_ |
1809210109842161664 |