Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants

Introduction: Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs. Methods: Randomi...

Descripción completa

Detalles Bibliográficos
Autores principales: Amaral, Diego, Galimberti, Griselda, Cuesta, Soledad, Pinto, Juana, Ferrario, Claudia, Graciela, Elena
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
hierro
hierro polimaltosato
sulfato ferroso
anemia
deficiencia de hierro
iron
iron polymaltose complex
ferrous sulphate
iron deficiency
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/21340
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-21340
record_format ojs
spelling I10-R327-article-213402024-08-27T18:23:02Z Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants Evaluación comparativa de eficacia y tolerancia de hierro sulfato y hierro polimaltosato para el tratamiento de anemia ferropenica en lactantes Amaral, Diego Galimberti, Griselda Cuesta, Soledad Pinto, Juana Ferrario, Claudia Graciela, Elena hierro hierro polimaltosato sulfato ferroso anemia deficiencia de hierro iron iron polymaltose complex ferrous sulphate anemia iron deficiency Introduction: Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs. Methods: Randomized, double-blind, controlled trial, including children aged 6 to 18 months with iron deficiency anemia (hemoglobin < 11 g/dl, transferrine saturation < 20%). Patients were randomly assigned to one of two treatments: iron polymaltose  complex (IPC) or ferrous sulphate (FS). Efficacy, tolerance and adverse events occurrence were evaluated. Results: 60 children with iron deficiency anemia were included; 29 in the FS group and 31 in the IPC group. There were no significant differences between groups regarding hemoglobin at baseline (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) and after 90 days treatment (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21).Also, there were no differences regarding adverse events frequency (FS: 4/29  y IPC: 9/31; p=0,2). Conclusions: In our study, there were no differences in efficacy and safety between FS and IPC in the treatment of children with iron deficiency anemia. Introducción: La anemia ferropénica es la deficiencia nutricional más frecuente en niños menores de 2 años, alcanzando una prevalencia de 34,1% en Argentina. El suplemento con hierro es la opción terapéutica de elección. El objetivo de nuestro trabajo fue evaluar la eficacia y tolerancia de dos formas farmacéuticas de hierro disponibles (polimatosato y sulfato).Métodos: Ensayo clínico controlado, aleatorizado, enmascarado "doble-ciego". Se incluyeron pacientes de 6 a 18 meses de edad con diagnóstico de anemia ferropénica (hemoglobina < 11 g/dl y saturación de transferrina < 20%), que fueron asignados aleatoriamente a dos tratamientos con hierro (6 mg/kg/día): hierro polimaltosato (HPM) o sulfato ferroso (SF). Se valoró eficacia, tolerancia y efectos adversos.Resultados: Se estudiaron 60 niños; 29 recibieron SF y 31 HPM. No se encontraron diferencias significativas entre ambos grupos en relación a valores de hemoglobina basal (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) y a los 90 días de tratamiento (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21). Tampoco se encontraron diferencias significativas en la frecuencia de efectos adversos entre ambos grupos (SF: 4/29 y HPM: 9/31; p=0,2).Conclusiones: No se encontraron diferencias significativas entre HPM y SF en cuanto a eficacia y presencia de efectos adversos en el tratamiento de niños de 6 a 18 meses con anemia ferropénica. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-09-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/21340 10.31053/1853.0605.v69.n2.21340 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 69 No. 2 (2012); 97-101 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 69 Núm. 2 (2012); 97-101 Revista da Faculdade de Ciências Médicas de Córdoba; v. 69 n. 2 (2012); 97-101 1853-0605 0014-6722 10.31053/1853.0605.v69.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/21340/20850 https://revistas.unc.edu.ar/index.php/med/article/view/21340/20864 Derechos de autor 2018 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic hierro
hierro polimaltosato
sulfato ferroso
anemia
deficiencia de hierro
iron
iron polymaltose complex
ferrous sulphate
anemia
iron deficiency
spellingShingle hierro
hierro polimaltosato
sulfato ferroso
anemia
deficiencia de hierro
iron
iron polymaltose complex
ferrous sulphate
anemia
iron deficiency
Amaral, Diego
Galimberti, Griselda
Cuesta, Soledad
Pinto, Juana
Ferrario, Claudia
Graciela, Elena
Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
topic_facet hierro
hierro polimaltosato
sulfato ferroso
anemia
deficiencia de hierro
iron
iron polymaltose complex
ferrous sulphate
anemia
iron deficiency
author Amaral, Diego
Galimberti, Griselda
Cuesta, Soledad
Pinto, Juana
Ferrario, Claudia
Graciela, Elena
author_facet Amaral, Diego
Galimberti, Griselda
Cuesta, Soledad
Pinto, Juana
Ferrario, Claudia
Graciela, Elena
author_sort Amaral, Diego
title Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
title_short Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
title_full Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
title_fullStr Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
title_full_unstemmed Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
title_sort comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants
description Introduction: Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs. Methods: Randomized, double-blind, controlled trial, including children aged 6 to 18 months with iron deficiency anemia (hemoglobin < 11 g/dl, transferrine saturation < 20%). Patients were randomly assigned to one of two treatments: iron polymaltose  complex (IPC) or ferrous sulphate (FS). Efficacy, tolerance and adverse events occurrence were evaluated. Results: 60 children with iron deficiency anemia were included; 29 in the FS group and 31 in the IPC group. There were no significant differences between groups regarding hemoglobin at baseline (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) and after 90 days treatment (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21).Also, there were no differences regarding adverse events frequency (FS: 4/29  y IPC: 9/31; p=0,2). Conclusions: In our study, there were no differences in efficacy and safety between FS and IPC in the treatment of children with iron deficiency anemia.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/21340
work_keys_str_mv AT amaraldiego comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT galimbertigriselda comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT cuestasoledad comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT pintojuana comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT ferrarioclaudia comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT gracielaelena comparativeevaluationofefficacyandtoleranceofironpolymaltosecomplexandferroussulphatefortreatmentofirondeficiencyanemiaininfants
AT amaraldiego evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
AT galimbertigriselda evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
AT cuestasoledad evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
AT pintojuana evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
AT ferrarioclaudia evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
AT gracielaelena evaluacioncomparativadeeficaciaytoleranciadehierrosulfatoyhierropolimaltosatoparaeltratamientodeanemiaferropenicaenlactantes
first_indexed 2024-09-03T20:59:52Z
last_indexed 2024-09-03T20:59:52Z
_version_ 1809210086077235200

Ejemplares similares