Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina

Introduction: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in patients older than 50 years. The diagnosis is based on the clinical history, laboratory findings and imaging studies associated with a temporal artery biopsy (TAB). However, the biopsy result could be inconclusive...

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Autores principales: de la Torre, María Laura, Kostianovsky, Alex, Pisoni, Cecilia Nora
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020
Materias:
review
giant cell arteritis
biopsy
revisión
arteritis de células gigantes
biopsia
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/21087
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-21087
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic review
giant cell arteritis
biopsy
revisión
arteritis de células gigantes
biopsia
spellingShingle review
giant cell arteritis
biopsy
revisión
arteritis de células gigantes
biopsia
de la Torre, María Laura
Kostianovsky, Alex
Pisoni, Cecilia Nora
Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
topic_facet review
giant cell arteritis
biopsy
revisión
arteritis de células gigantes
biopsia
author de la Torre, María Laura
Kostianovsky, Alex
Pisoni, Cecilia Nora
author_facet de la Torre, María Laura
Kostianovsky, Alex
Pisoni, Cecilia Nora
author_sort de la Torre, María Laura
title Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
title_short Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
title_full Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
title_fullStr Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
title_full_unstemmed Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina
title_sort anatomoclinical results of temporal artery biopsies at a university hospital in argentina
description Introduction: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in patients older than 50 years. The diagnosis is based on the clinical history, laboratory findings and imaging studies associated with a temporal artery biopsy (TAB). However, the biopsy result could be inconclusive in up to 40% of the cases. The aim of this study was to review the current management of the patients with clinical suspect of GCA in the university hospital CEMIC in Buenos Aires, Argentina, and correlate the disease behavior with the TAB result. Methods: Retrospective study that reviewed consecutive patients to whom a TAB was made in an 11-year period (2005-2016). Clinical and pathology reports were reviewed. Descriptive statistics were performed. Quantitative variables were described as mean (S.D.) or median [range or inter- quartile range (IQR)] and qualitative variables as number (%). To compare the characteristics of the groups, bivariate analyzes were performed using contingency tables and logistic regression models if necessary. Results: Sixty three patients were included, 68% women. The mean age was 72 years old (SD 8.4). Seventeen biopsies (26.9%) were positive for GCA. The average post fixation length was 1.68 cm (SD 1.2). Patients were divided into 3 groups taking into account the result of the TAB, the ACR criteria and the imaging studies. We could not identify predictors of biopsy positivity. The group of patients with GCA and negative TAB showed a higher percentage of patients with abnormal temporal artery at physical examination. Conclusion: The TAB positive percentage (26.9%) was similar to the reported in other series as well as the post fixation length.  We could not identify predictors of biopsy positivity.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2020
url https://revistas.unc.edu.ar/index.php/med/article/view/21087
work_keys_str_mv AT delatorremarialaura anatomoclinicalresultsoftemporalarterybiopsiesatauniversityhospitalinargentina
AT kostianovskyalex anatomoclinicalresultsoftemporalarterybiopsiesatauniversityhospitalinargentina
AT pisonicecilianora anatomoclinicalresultsoftemporalarterybiopsiesatauniversityhospitalinargentina
AT delatorremarialaura resultadosanatomoclinicosdelasbiopsiasdearteriatemporalrealizadasenunhospitaluniversitariodeargentina
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AT pisonicecilianora resultadosanatomoclinicosdelasbiopsiasdearteriatemporalrealizadasenunhospitaluniversitariodeargentina
first_indexed 2024-09-03T20:59:34Z
last_indexed 2024-09-03T20:59:34Z
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spelling I10-R327-article-210872024-08-27T18:22:36Z Anatomoclinical results of temporal artery biopsies at a university hospital in Argentina Resultados anatomoclínicos de las biopsias de arteria temporal realizadas en un hospital universitario de Argentina de la Torre, María Laura Kostianovsky, Alex Pisoni, Cecilia Nora review giant cell arteritis biopsy revisión arteritis de células gigantes biopsia Introduction: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in patients older than 50 years. The diagnosis is based on the clinical history, laboratory findings and imaging studies associated with a temporal artery biopsy (TAB). However, the biopsy result could be inconclusive in up to 40% of the cases. The aim of this study was to review the current management of the patients with clinical suspect of GCA in the university hospital CEMIC in Buenos Aires, Argentina, and correlate the disease behavior with the TAB result. Methods: Retrospective study that reviewed consecutive patients to whom a TAB was made in an 11-year period (2005-2016). Clinical and pathology reports were reviewed. Descriptive statistics were performed. Quantitative variables were described as mean (S.D.) or median [range or inter- quartile range (IQR)] and qualitative variables as number (%). To compare the characteristics of the groups, bivariate analyzes were performed using contingency tables and logistic regression models if necessary. Results: Sixty three patients were included, 68% women. The mean age was 72 years old (SD 8.4). Seventeen biopsies (26.9%) were positive for GCA. The average post fixation length was 1.68 cm (SD 1.2). Patients were divided into 3 groups taking into account the result of the TAB, the ACR criteria and the imaging studies. We could not identify predictors of biopsy positivity. The group of patients with GCA and negative TAB showed a higher percentage of patients with abnormal temporal artery at physical examination. Conclusion: The TAB positive percentage (26.9%) was similar to the reported in other series as well as the post fixation length.  We could not identify predictors of biopsy positivity. Introducción: La arteritis de células gigantes (ACG) es la vasculitis sistémica primaria más frecuente en pacientes mayores de 50 años. El diagnóstico de ACG se basa en la evaluación clínica, de laboratorio y estudios por imágenes, asociados a una biopsia. Sin embargo, el resultado de la biopsia puede no ser concluyente en más del 40% de los casos. El objetivo de este estudio fue revisar el manejo de los pacientes con sospecha de ACG en el hospital universitario CEMIC en Buenos Aires, Argentina, y correlacionar el comportamiento de la enfermedad con el resultado de la biopsia de arteria temporal (BAT). Métodos: Estudio retrospectivo que analizó pacientes consecutivos a los cuales se les realizó BAT en un período de 11 años (2005-2016). La información recolectada se obtuvo a partir de las historias clínicas y de los informes de anatomía patológica. Se realizó estadística descriptiva. Para las variables cuantitativas se estimaron medias y sus respectivos desvíos estándar o medianas y percentil 25-75, y para las variables cualitativas, la cantidad y el porcentaje.  Para comparar las características de los grupos se realizaron análisis bivariados mediante tablas de contingencia y modelos de regresión logística de ser necesario. Resultados: Sesenta y tres pacientes fueron incluidos,  68% mujeres, con una edad media de 72 años (DS 8,4). Diecisiete biopsias (26,9%) fueron positivas. La longitud media posfijación fue de 1,68 cm (DS 1,2). La población se dividió en 3 grupos según la BAT, los criterios ACR y los estudios por imágenes. No se identificaron factores predictores de positividad de la BAT. El grupo con ACG y BAT negativa presentó mayor porcentaje de pacientes con arteria temporal anormal al examen físico. Conclusión: El porcentaje de positividad de las biopsias (26,9%) fue similar al reportado por otras series, así como la longitud de la biopsia luego de la fijación (1,68 cm). No identificamos factores predictores de positividad de la BAT. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-03-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/21087 10.31053/1853.0605.v76.n4.21087 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 77 No. 1 (2020); 4-9 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm. 1 (2020); 4-9 Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 1 (2020); 4-9 1853-0605 0014-6722 10.31053/1853.0605.v77.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/21087/29192 https://revistas.unc.edu.ar/index.php/med/article/view/21087/29205 Derechos de autor 2020 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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