Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications

Background: Mitochondrial activity is essential for cardiac and skeletal muscle. The relationship between mitochondrial dysfunction and different cardiovascular conditions has been well described. Pharmacological treatment for heart failure involves different drugs as: angiotensin-converting enzyme...

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Detalles Bibliográficos
Autores principales: Camino Willhuber, Gaston Oscar, Guzman Mentesana, Gustavo, Baez, Alejandra, Lo Presti, Silvina, Bazán, Carolina, Strauss, Mariana, Fretes, Ricardo, Paglini-Oliva, Patricia Adriana, Rivarola, Hector Walter
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
mitochondrial function
heart failure medication
mitochodrial morphology.
Término 1
función mitocondrial
Término 2
insuficiencia cardíaca
Término 3
morfología mitocondrial
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/15297
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-15297
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic mitochondrial function
heart failure medication
mitochodrial morphology.
Término 1
función mitocondrial
Término 2
insuficiencia cardíaca
Término 3
morfología mitocondrial
spellingShingle mitochondrial function
heart failure medication
mitochodrial morphology.
Término 1
función mitocondrial
Término 2
insuficiencia cardíaca
Término 3
morfología mitocondrial
Camino Willhuber, Gaston Oscar
Guzman Mentesana, Gustavo
Baez, Alejandra
Lo Presti, Silvina
Bazán, Carolina
Strauss, Mariana
Fretes, Ricardo
Paglini-Oliva, Patricia Adriana
Rivarola, Hector Walter
Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
topic_facet mitochondrial function
heart failure medication
mitochodrial morphology.
Término 1
función mitocondrial
Término 2
insuficiencia cardíaca
Término 3
morfología mitocondrial
author Camino Willhuber, Gaston Oscar
Guzman Mentesana, Gustavo
Baez, Alejandra
Lo Presti, Silvina
Bazán, Carolina
Strauss, Mariana
Fretes, Ricardo
Paglini-Oliva, Patricia Adriana
Rivarola, Hector Walter
author_facet Camino Willhuber, Gaston Oscar
Guzman Mentesana, Gustavo
Baez, Alejandra
Lo Presti, Silvina
Bazán, Carolina
Strauss, Mariana
Fretes, Ricardo
Paglini-Oliva, Patricia Adriana
Rivarola, Hector Walter
author_sort Camino Willhuber, Gaston Oscar
title Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
title_short Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
title_full Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
title_fullStr Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
title_full_unstemmed Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
title_sort analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications
description Background: Mitochondrial activity is essential for cardiac and skeletal muscle. The relationship between mitochondrial dysfunction and different cardiovascular conditions has been well described. Pharmacological treatment for heart failure involves different drugs as: angiotensin-converting enzyme inhibitors, B-adrenergic blockers, digitalis glycosides and diuretics. The clinical benefit from medication is clear, however, the role of this drugs in mitochondrial metabolisms is not well understood. Aim of the study: The objective of our study was to analyze structural and functional characteristics of cardiac and skeletal muscle mitochondria in mice treated with drugs normally used for heart failure and compare it to a control group. Methods: Twenty-five Albino Mice divided in five groups were treated with heart failure medication during 30 days (group I to IV). 30 days after treatment they were sacrificed, heart and skeletal muscle were analyzed and compared with a control group (V). Results: Enzymatic activity was slightly increased in groups treated with heart failure medication compared to control group (p>0.05). Mitochondrial morphology was significantly altered in groups treated compared to control group, in addition, mitochondrial area was significantly increased in the treated groups, in both cardiac and skeletal muscle. Conclusions: We concluded that heart failure medication could produce modifications in mitochondrial function; we believe that mitochondria maintains the enzymatic activity by increasing size and modifying morphology.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/15297
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spelling I10-R327-article-152972024-08-27T18:20:19Z Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications Análisis de la función y ultraestructura mitocondrial en ratones albinos sanos tratados con medicamentos para insuficiencia cardíaca Camino Willhuber, Gaston Oscar Guzman Mentesana, Gustavo Baez, Alejandra Lo Presti, Silvina Bazán, Carolina Strauss, Mariana Fretes, Ricardo Paglini-Oliva, Patricia Adriana Rivarola, Hector Walter mitochondrial function heart failure medication mitochodrial morphology. Término 1 función mitocondrial Término 2 insuficiencia cardíaca Término 3 morfología mitocondrial Background: Mitochondrial activity is essential for cardiac and skeletal muscle. The relationship between mitochondrial dysfunction and different cardiovascular conditions has been well described. Pharmacological treatment for heart failure involves different drugs as: angiotensin-converting enzyme inhibitors, B-adrenergic blockers, digitalis glycosides and diuretics. The clinical benefit from medication is clear, however, the role of this drugs in mitochondrial metabolisms is not well understood. Aim of the study: The objective of our study was to analyze structural and functional characteristics of cardiac and skeletal muscle mitochondria in mice treated with drugs normally used for heart failure and compare it to a control group. Methods: Twenty-five Albino Mice divided in five groups were treated with heart failure medication during 30 days (group I to IV). 30 days after treatment they were sacrificed, heart and skeletal muscle were analyzed and compared with a control group (V). Results: Enzymatic activity was slightly increased in groups treated with heart failure medication compared to control group (p>0.05). Mitochondrial morphology was significantly altered in groups treated compared to control group, in addition, mitochondrial area was significantly increased in the treated groups, in both cardiac and skeletal muscle. Conclusions: We concluded that heart failure medication could produce modifications in mitochondrial function; we believe that mitochondria maintains the enzymatic activity by increasing size and modifying morphology.   Resumen Introducción: la actividad mitocondrial es esencial para el músculo cardíaco y esquelético. La relación entre la disfunción mitocondrial y diferentes condiciones cardiovasculares ha sido bien descrita. El tratamiento farmacológico de la insuficiencia cardíaca implica diferentes medicamentos como: inhibidores de la enzima convertidora de la angiotensina, bloqueadores B-adrenérgicos, glucósidos digitálicos y diuréticos. Los beneficios clínicos del tratamiento son claros, sin embargo, el papel de estos fármacos en el metabolismo mitocondrial no esta bien establecido. Objetivo del estudio: El objetivo de nuestro estudio fue analizar las características estructurales y funcionales de las mitocondrias del músculo cardíaco y esquelético en ratones tratados con fármacos habitualmente utilizados para la insuficiencia cardíaca y compararlo con un grupo control. Métodos: Veinticinco ratones albinos divididos en cinco grupos fueron tratados con la medicación para insuficiencia cardíaca durante 30 días (grupo I a IV). 30 días después del tratamiento se sacrificaron, el corazón y el músculo esquelético se analizaron y se compararon con un grupo control (V). Resultados: La actividad enzimática se incrementó ligeramente en los grupos tratados con medicamentos insuficiencia cardiaca en comparación con el grupo control (p> 0,05). morfología mitocondrial se modificó significativamente en los grupos tratados en comparación con el grupo control, además, el área mitocondrial fue significativamente mayor en los grupos tratados, tanto en el músculo cardíaco y estriado. Conclusiones: Concluimos que la medicación insuficiencia cardíaca podría producir modificaciones en la función mitocondrial; creemos que las mitocondrias pueden mantener la actividad enzimática mediante el aumento de tamaño y modificación de la morfología. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-09-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/15297 10.31053/1853.0605.v74.n3.15297 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 3 (2017); 231-238 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 3 (2017); 231-238 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 3 (2017); 231-238 1853-0605 0014-6722 10.31053/1853.0605.v74.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/15297/19141 Derechos de autor 2017 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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