Innate receptors and IL-17 in the immune response against human pathogenic fungi

In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors...

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Autores principales: Miró, María Soledad, Vigezzi, Cecilia, Rodriguez, Emilse, Icely, Paula Alejandra, Caeiro, Juan Pablo, Riera, Fernando Oscar, Masih, Diana Teresa, Sotomayor, Claudia Elena
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
infecciones fungicas humanas
receptores nnatos
inflamasomas, IL-17
inmunidad antifungica
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/13353
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-13353
record_format ojs
spelling I10-R327-article-133532024-08-29T14:44:48Z Innate receptors and IL-17 in the immune response against human pathogenic fungi Receptores innatos e il-17 en la respuesta inmune frente a hongos patógenos humanos Miró, María Soledad Vigezzi, Cecilia Rodriguez, Emilse Icely, Paula Alejandra Caeiro, Juan Pablo Riera, Fernando Oscar Masih, Diana Teresa Sotomayor, Claudia Elena Human fungal infections antifungal immunity innate receptors Dectin-1 Inflamasommes IL-17 infecciones fungicas humanas receptores nnatos Dectin-1 inflamasomas, IL-17 inmunidad antifungica In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system.  This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed Durante los últimos años, el aumento de las infecciones fúngicas invasivas en humanos, emerge asociado a la faltade diagnóstico precoz, terapias antifúngicas efectivas y al desarrollo de vacunas. Perturbaciones en la homeostasisinmune debido a intervenciones médicas o a estados de inmunosupresión inducidos por diferentes enfermedades,son conocidos factores de riesgo para la adquisición de estas micosis. Las células del sistema inmune innato estánequipadas con receptores de superficie y citoplasmáticos que permiten el reconocimiento de diferentes microorganismos y que colectivamente han sido denominados Receptores de Reconocimiento de Patrones (PRRs). EstosPRRs reconocen estructuras altamente conservadas en los microorganismos identificadas como Patrones Moleculares Asociados a Patógenos (PAMPs), que son claves para la activación del sistema inmune y la inducción demuerte de estos patógenos fúngicos. Esta revisión aborda el rol de los PRRs, la participación de diferentes célulasen el desarrollo de una respuesta efectiva, con especial foco en la contribución de la IL-17 en la inmunidadantifúngica. La presencia de mutaciones naturales en humanos que confieren susceptibilidad a infecciones porhongos, su implicancia clínica y su aporte al conocimiento de la etiopatogenia de estas micosis es abordada eneste artículo Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-08-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/13353 10.31053/1853.0605.v73.n3.13353 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 73 No. 3 (2016); 188-196 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 73 Núm. 3 (2016); 188-196 Revista da Faculdade de Ciências Médicas de Córdoba; v. 73 n. 3 (2016); 188-196 1853-0605 0014-6722 10.31053/1853.0605.v73.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/13353/46479 Derechos de autor 2018 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
infecciones fungicas humanas
receptores nnatos
Dectin-1
inflamasomas, IL-17
inmunidad antifungica
spellingShingle Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
infecciones fungicas humanas
receptores nnatos
Dectin-1
inflamasomas, IL-17
inmunidad antifungica
Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
Innate receptors and IL-17 in the immune response against human pathogenic fungi
topic_facet Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
infecciones fungicas humanas
receptores nnatos
Dectin-1
inflamasomas, IL-17
inmunidad antifungica
author Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
author_facet Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
author_sort Miró, María Soledad
title Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_short Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_full Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_fullStr Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_full_unstemmed Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_sort innate receptors and il-17 in the immune response against human pathogenic fungi
description In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system.  This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/13353
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first_indexed 2024-09-03T20:58:07Z
last_indexed 2024-09-03T20:58:07Z
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