IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?

Objectives: Considerable differences are known between proximal and distal colon, these include embryological, anatomical, histological, biochemical, and physiological characteristics. Above mentioned distinctions may influence development of variable clinico-morphological entities. Multifunctional...

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Detalles Bibliográficos
Autores principales: Adamkov, Marian, Hurta Csizmar, Sandra, Mestanova, Veronika, Vybohova, Desanka, Krajnakova, Bibiana
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy) 2022
Materias:
proximal and distal colon
adenomas
survivin
colon proximal y distal
Acceso en línea:https://revistas.unc.edu.ar/index.php/anatclinar/article/view/37625
Aporte de:
Revista Argentina de Anatomía Clínica de Universidad Nacional de Córdoba
id I10-R321-article-37625
record_format ojs
spelling I10-R321-article-376252022-07-29T23:09:11Z IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON? Es idéntico el nivel de survivina entre los adenomas de colon proximal y distal? Adamkov, Marian Hurta Csizmar, Sandra Mestanova, Veronika Vybohova, Desanka Krajnakova, Bibiana proximal and distal colon adenomas survivin colon proximal y distal adenomas survivin Objectives: Considerable differences are known between proximal and distal colon, these include embryological, anatomical, histological, biochemical, and physiological characteristics. Above mentioned distinctions may influence development of variable clinico-morphological entities. Multifunctional antiapoptotic protein survivin participates in regulation of cell cycle, apoptotic cascades, and stimulates angiogenesis. Material and methods: We assessed immunohistochemically expression pattern of antiapoptotic protein survivin in a panel of 243 colon adenomas to determine its association with colon localization. In each section, subcellular compartmentalization of survivin and intensity of immunoreaction were evaluated. Results: Survivin was expressed in 190 cases (78.2%). Statistical analysis confirmed a significant correlation of subcellular survivin compartmentalization and intensity of immunoreaction with colon localization of adenomas. Conclusions: Taking into account unique features of survivin, its expression pattern in proximally sided adenomas, and distinctions between left and right colon, we suppose that survivin level may contribute to higher proliferative phenotype of proximal adenomas. Objetivos: Se conocen diferencias considerables entre el colon proximal y el distal, estas incluyen características embriológicas, anatómicas, histológicas, bioquímicas y fisiológicas. Las distinciones antes mencionadas pueden influir en el desarrollo de entidades clínico-morfológicas variables. La proteína antiapoptótica multifuncional survivina participa en la regulación del ciclo celular, las cascadas apoptóticas y estimula la angiogénesis. Material y métodos: Se evaluó inmunohistoquímicamente el patrón de expresión de la proteína antiapoptótica survivina en un panel de 243 adenomas de colon para determinar su asociación con la localización colónica. En cada sección se evaluó la compartimentación subcelular de la survivina y la intensidad de la inmunorreacción. Resultados: La survivina se expresó en 190 casos (78,2%). El análisis estadístico confirmó una correlación significativa de la compartimentación subcelular de survivina y la intensidad de la inmunorreacción con la localización de los adenomas en el colon. Conclusiones: Teniendo en cuenta las características únicas de la survivina, su patrón de expresión en los adenomas del lado proximal y las distinciones entre el colon derecho e izquierdo, suponemos que el nivel de survivina puede contribuir a un mayor fenotipo proliferativo de los adenomas proximales. Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy) 2022-07-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/anatclinar/article/view/37625 10.31051/1852.8023.v14.n2.37625 Revista Argentina de Anatomía Clínica (Argentine Journal of Clinical Anatomy); Vol. 14 No. 2 (2022): Jul 2022; 58-64 Revista Argentina de Anatomía Clínica; Vol. 14 Núm. 2 (2022): Jul 2022; 58-64 1852-8023 10.31051/1852.8023.v14.n2 eng https://revistas.unc.edu.ar/index.php/anatclinar/article/view/37625/38447 Derechos de autor 2022 Marian Adamkov, Sandra Hurta Csizmar, Veronika Mestanova, Desanka Vybohova, Bibiana Krajnakova http://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-321
container_title_str Revista Argentina de Anatomía Clínica
language Inglés
format Artículo revista
topic proximal and distal colon
adenomas
survivin
colon proximal y distal
adenomas
survivin
spellingShingle proximal and distal colon
adenomas
survivin
colon proximal y distal
adenomas
survivin
Adamkov, Marian
Hurta Csizmar, Sandra
Mestanova, Veronika
Vybohova, Desanka
Krajnakova, Bibiana
IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
topic_facet proximal and distal colon
adenomas
survivin
colon proximal y distal
adenomas
survivin
author Adamkov, Marian
Hurta Csizmar, Sandra
Mestanova, Veronika
Vybohova, Desanka
Krajnakova, Bibiana
author_facet Adamkov, Marian
Hurta Csizmar, Sandra
Mestanova, Veronika
Vybohova, Desanka
Krajnakova, Bibiana
author_sort Adamkov, Marian
title IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
title_short IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
title_full IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
title_fullStr IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
title_full_unstemmed IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?
title_sort is survivin level identical between adenomas of proximal and distal colon?
description Objectives: Considerable differences are known between proximal and distal colon, these include embryological, anatomical, histological, biochemical, and physiological characteristics. Above mentioned distinctions may influence development of variable clinico-morphological entities. Multifunctional antiapoptotic protein survivin participates in regulation of cell cycle, apoptotic cascades, and stimulates angiogenesis. Material and methods: We assessed immunohistochemically expression pattern of antiapoptotic protein survivin in a panel of 243 colon adenomas to determine its association with colon localization. In each section, subcellular compartmentalization of survivin and intensity of immunoreaction were evaluated. Results: Survivin was expressed in 190 cases (78.2%). Statistical analysis confirmed a significant correlation of subcellular survivin compartmentalization and intensity of immunoreaction with colon localization of adenomas. Conclusions: Taking into account unique features of survivin, its expression pattern in proximally sided adenomas, and distinctions between left and right colon, we suppose that survivin level may contribute to higher proliferative phenotype of proximal adenomas.
publisher Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy)
publishDate 2022
url https://revistas.unc.edu.ar/index.php/anatclinar/article/view/37625
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first_indexed 2024-09-03T22:46:59Z
last_indexed 2024-09-03T22:46:59Z
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