TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT

The purpose of the study was to determinate the morphometric parameters of epithelial cords, prostatic ducts, acini of the human prostate gland and their lining epithelium, the shape of prostate glands, and muscle tissue in fetal periods of development. Material and Method: The study was performed o...

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Detalles Bibliográficos
Autores principales: Piatsko, Irina, Usovich, Alexander
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy) 2020
Materias:
apoptosis
glándula prostática
canalización
canalization
prostate development
Acceso en línea:https://revistas.unc.edu.ar/index.php/anatclinar/article/view/28837
Aporte de:
Revista Argentina de Anatomía Clínica de Universidad Nacional de Córdoba
id I10-R321-article-28837
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-321
container_title_str Revista Argentina de Anatomía Clínica
language Inglés
format Artículo revista
topic apoptosis
glándula prostática
canalización
apoptosis
canalization
prostate development
spellingShingle apoptosis
glándula prostática
canalización
apoptosis
canalization
prostate development
Piatsko, Irina
Usovich, Alexander
TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
topic_facet apoptosis
glándula prostática
canalización
apoptosis
canalization
prostate development
author Piatsko, Irina
Usovich, Alexander
author_facet Piatsko, Irina
Usovich, Alexander
author_sort Piatsko, Irina
title TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
title_short TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
title_full TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
title_fullStr TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
title_full_unstemmed TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT
title_sort transformation of the human prostate gland in intermediate and late fetal periods of development
description The purpose of the study was to determinate the morphometric parameters of epithelial cords, prostatic ducts, acini of the human prostate gland and their lining epithelium, the shape of prostate glands, and muscle tissue in fetal periods of development. Material and Method: The study was performed on 19 prostate glands of male sex fetuses of intermediate and late fetal periods. We used the morphometric method of verification of apoptotic cells on stained histoligical preps using the criteria of apoptosis. Morphometric research included measurements of acini and acinar lumen areas, epithelium height, assessment of shape factors. Results: In the late fetal period compared to the intermediate fetal period the acini area was not increased in 1.1 times (p =0,004), the area of acinar lumens increases by 3.8 times (p=0.0005). Changes in the shape of acinar lumens were detected. Conclusion: An insignificant increase of the specific area of the glandular parenchyma in the organ of transformation of the developing glands occurs mainly due to their canalization. The formation of prostatic ducts was not followed by the increase in their total area and was the result of differentiation epithelial cells and apoptosis. Transformation of prostate glands in the prenatal period occurs in a certain sequence: the formation of epithelial buds, their canalization by apoptosis with formation of epithelial ducts and prostatic ducts, and formation of end pieces of prostate glands from these ducts. Apoptotic bodies were removed from the lumen of the prostatic ducts by extrusion. The design and orientation of the smooth muscle bundles around prostatic ducts and acini do not ensure the evacuation of content of the prostate glands in the fetal period.
publisher Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy)
publishDate 2020
url https://revistas.unc.edu.ar/index.php/anatclinar/article/view/28837
work_keys_str_mv AT piatskoirina transformationofthehumanprostateglandinintermediateandlatefetalperiodsofdevelopment
AT usovichalexander transformationofthehumanprostateglandinintermediateandlatefetalperiodsofdevelopment
AT piatskoirina transformaciondelaglandulaprostaticahumanaenlosperiodosdedesarrollofetalintermedioytario
AT usovichalexander transformaciondelaglandulaprostaticahumanaenlosperiodosdedesarrollofetalintermedioytario
first_indexed 2024-09-03T22:46:42Z
last_indexed 2024-09-03T22:46:42Z
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spelling I10-R321-article-288372020-12-06T18:39:04Z TRANSFORMATION OF THE HUMAN PROSTATE GLAND IN INTERMEDIATE AND LATE FETAL PERIODS OF DEVELOPMENT Transformación de la glándula prostática humana en los períodos de desarrollo fetal intermedio y tarío Piatsko, Irina Usovich, Alexander apoptosis glándula prostática canalización apoptosis canalization prostate development The purpose of the study was to determinate the morphometric parameters of epithelial cords, prostatic ducts, acini of the human prostate gland and their lining epithelium, the shape of prostate glands, and muscle tissue in fetal periods of development. Material and Method: The study was performed on 19 prostate glands of male sex fetuses of intermediate and late fetal periods. We used the morphometric method of verification of apoptotic cells on stained histoligical preps using the criteria of apoptosis. Morphometric research included measurements of acini and acinar lumen areas, epithelium height, assessment of shape factors. Results: In the late fetal period compared to the intermediate fetal period the acini area was not increased in 1.1 times (p =0,004), the area of acinar lumens increases by 3.8 times (p=0.0005). Changes in the shape of acinar lumens were detected. Conclusion: An insignificant increase of the specific area of the glandular parenchyma in the organ of transformation of the developing glands occurs mainly due to their canalization. The formation of prostatic ducts was not followed by the increase in their total area and was the result of differentiation epithelial cells and apoptosis. Transformation of prostate glands in the prenatal period occurs in a certain sequence: the formation of epithelial buds, their canalization by apoptosis with formation of epithelial ducts and prostatic ducts, and formation of end pieces of prostate glands from these ducts. Apoptotic bodies were removed from the lumen of the prostatic ducts by extrusion. The design and orientation of the smooth muscle bundles around prostatic ducts and acini do not ensure the evacuation of content of the prostate glands in the fetal period. Como el objetivo del estudio se ha planteado determinar los parâmetros morfométricos de los cordones epiteliales, los conductos prostáticos, luces de las glándulas finales de la próstata humana y el epitelio de revestimiento, las formas de las glándulas finales de la próstata humana, determinación de la relación entre las glándulas de la próstata y su tejido muscular durante los períodos del desarrollo fetal. Material y métodos. El estudio se ha realizado en 19 próstatas de niños de los períodos fetales medio y tardío. Utilizamos un método morfométrico para verificar las células apoptóticas en especimenes histológicos teñidos utilizando criterios de apoptosis. Los estudios morfométricos incluyeron mediciones del área de las glándulas terminales y sus luces, la altura del epitelio, la evaluación de los factores de forma. Resultados. En el último período de desarrollo fetal, en comparación con el período intermedio del desarrollo fetal, el área de las glándulas finales aumentó 1,1 veces (p <0,05); el área luminal de de las glándulas finales aumentó 3.8 veces (p <0.05); hubo un cambio en la forma de los luces de las glândulas finales (p <0.05). Conclusión. Un ligero aumento en el área específica del parénquima glandular en la próstata en desarrollo del feto masculino durante la transformación de las glándulas en desarrollo ocurre principalmente debido a la aparicion de las luces. La formación de conductos prostáticos no há sido acompañada por un aumento en su área total, sino que se ha presentado como el resultado de la diferenciación de las células epiteliales y la apoptosis. La transformación de la próstata en el período prenatal de ontogénesis ocurre en una secuencia determinada: la formación de túbulos epiteliales de los cordones epiteliales, su transformación en conductos prostáticos y la formación de las glândulas finales de la prostata. Los cuerpos apoptóticos se eliminan de la luz de los conductos prostáticos por medio de extrusión. La estructura y la disposición de los haces de músculo liso alrededor de los conductos prostáticos y de las glándulas finales no pueden garantizar la secrecion de su contenido durante la edad fetal. Asociación Argentina de Anatomía Clínica (Argentine Association of Clinical Anatomy) 2020-11-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/anatclinar/article/view/28837 10.31051/1852.8023.v12.n3.28837 Revista Argentina de Anatomía Clínica (Argentine Journal of Clinical Anatomy); Vol. 12 No. 3 (2020): Nov 2020; 131-136 Revista Argentina de Anatomía Clínica; Vol. 12 Núm. 3 (2020): Nov 2020; 131-136 1852-8023 10.31051/1852.8023.v12.n3 eng https://revistas.unc.edu.ar/index.php/anatclinar/article/view/28837/31635 Derechos de autor 2020 Irina Piatsko, Alexander Usovich http://creativecommons.org/licenses/by-nc/4.0

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