Apoptosis, Physiological Cell Death, Historical Review and Current Status
The concept of Programmed Cell Death (PCD) has been used since 1951, andthe idea of the physiological cell death and the term apoptosis was established in 1972.Apoptosis occurs in embryonic cells at specific times and it is crucial for the embryosdevelopment. The tissues are remodeled by cell death...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Asociación de Docentes de Ciencias Biológicas de la Argentina
2014
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/revistaadbia/article/view/22425 |
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| Sumario: | The concept of Programmed Cell Death (PCD) has been used since 1951, andthe idea of the physiological cell death and the term apoptosis was established in 1972.Apoptosis occurs in embryonic cells at specific times and it is crucial for the embryosdevelopment. The tissues are remodeled by cell death under genetic control and withoutdamaging the surrounding tissues. If the normal mitosis/apoptosis rate is altered duringtissue formation, birth defects may appear. The physiological meaning of PCD is differentfrom necrosis. While necrosis is accidental and damaged cells are removed from the tissuesusing the inflammatory process, apoptosis is a metabolic pathway and has evolved in lifeorganisms because it is necessary for morphogenesis and differentiation in specialized andcomplex tissues. In this work we review the understanding of apoptosis for the past 42years. |
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