Apoptosis, Physiological Cell Death, Historical Review and Current Status

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The concept of Programmed Cell Death (PCD) has been used since 1951, andthe idea of the physiological cell death and the term apoptosis was established in 1972.Apoptosis occurs in embryonic cells at specific times and it is crucial for the embryosdevelopment. The tissues are remodeled by cell death...

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Autor principal: Espinosa, María Beatriz
Formato: Artículo revista
Lenguaje:Español
Publicado: Asociación de Docentes de Ciencias Biológicas de la Argentina 2014
Acceso en línea:https://revistas.unc.edu.ar/index.php/revistaadbia/article/view/22425
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Revista de Educación en Biología de Universidad Nacional de Córdoba
id I10-R313-article-22425
record_format ojs
spelling I10-R313-article-224252021-11-12T18:42:09Z Apoptosis, Physiological Cell Death, Historical Review and Current Status Apoptosis, muerte celular fisiológica, reseña histórica y actualidad. Apoptosis, Physiological Cell Death, Historical Review and Current Status. Espinosa, María Beatriz The concept of Programmed Cell Death (PCD) has been used since 1951, andthe idea of the physiological cell death and the term apoptosis was established in 1972.Apoptosis occurs in embryonic cells at specific times and it is crucial for the embryosdevelopment. The tissues are remodeled by cell death under genetic control and withoutdamaging the surrounding tissues. If the normal mitosis/apoptosis rate is altered duringtissue formation, birth defects may appear. The physiological meaning of PCD is differentfrom necrosis. While necrosis is accidental and damaged cells are removed from the tissuesusing the inflammatory process, apoptosis is a metabolic pathway and has evolved in lifeorganisms because it is necessary for morphogenesis and differentiation in specialized andcomplex tissues. In this work we review the understanding of apoptosis for the past 42years. El concepto de muerte celular programada, descripto a mediados del siglo XX, se definió como “apoptosis” en 1972 y se diferenció de la necrosis. La apoptosis  ó “Programmed Cell Death” (PCD) ocurre en un momento específico del desarrollo embrionario y también en los tejidos adultos. Los tejidos se remodelan mediante apoptosis bajo control genético sin dañar el tejido circundante. Tanto la mitosis (proliferación) como la apoptosis, durante la formación de los tejidos, están reguladas genéticamente. El significado fisiológico de la apoptosis es completamente distinto al de la necrosis. Mientras que la necrosis es accidental y las células lesionadas se remueven provocando inflamación, la apoptosis es una vía metabólica celular, regulada genéticamente. En este trabajo revisamos el progreso del conocimiento del tema durante los últimos 42 años. Asociación de Docentes de Ciencias Biológicas de la Argentina 2014-06-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/revistaadbia/article/view/22425 10.59524/2344-9225.v17.n1.22425 Journal of Biology Education; Vol. 17 No. 1 (2014): Revista de Educación en Biología; (pp. 153-159) Revista de Educación en Biología; Vol. 17 Núm. 1 (2014): Revista de Educación en Biología; (pp. 153-159) 2344-9225 0329-5192 10.59524/2344.9225.v17.n1 spa https://revistas.unc.edu.ar/index.php/revistaadbia/article/view/22425/22043 Derechos de autor 2014 María Beatriz Espinosa https://creativecommons.org/licenses/by-nc-sa/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-313
container_title_str Revista de Educación en Biología
language Español
format Artículo revista
author Espinosa, María Beatriz
spellingShingle Espinosa, María Beatriz
Apoptosis, Physiological Cell Death, Historical Review and Current Status
author_facet Espinosa, María Beatriz
author_sort Espinosa, María Beatriz
title Apoptosis, Physiological Cell Death, Historical Review and Current Status
title_short Apoptosis, Physiological Cell Death, Historical Review and Current Status
title_full Apoptosis, Physiological Cell Death, Historical Review and Current Status
title_fullStr Apoptosis, Physiological Cell Death, Historical Review and Current Status
title_full_unstemmed Apoptosis, Physiological Cell Death, Historical Review and Current Status
title_sort apoptosis, physiological cell death, historical review and current status
description The concept of Programmed Cell Death (PCD) has been used since 1951, andthe idea of the physiological cell death and the term apoptosis was established in 1972.Apoptosis occurs in embryonic cells at specific times and it is crucial for the embryosdevelopment. The tissues are remodeled by cell death under genetic control and withoutdamaging the surrounding tissues. If the normal mitosis/apoptosis rate is altered duringtissue formation, birth defects may appear. The physiological meaning of PCD is differentfrom necrosis. While necrosis is accidental and damaged cells are removed from the tissuesusing the inflammatory process, apoptosis is a metabolic pathway and has evolved in lifeorganisms because it is necessary for morphogenesis and differentiation in specialized andcomplex tissues. In this work we review the understanding of apoptosis for the past 42years.
publisher Asociación de Docentes de Ciencias Biológicas de la Argentina
publishDate 2014
url https://revistas.unc.edu.ar/index.php/revistaadbia/article/view/22425
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AT espinosamariabeatriz apoptosismuertecelularfisiologicaresenahistoricayactualidadapoptosisphysiologicalcelldeathhistoricalreviewandcurrentstatus
first_indexed 2024-09-03T20:30:35Z
last_indexed 2024-09-03T20:30:35Z
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