Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina

Objectives: The aim of this study was to investigate the distribution of molecular polymorphisms of the ABO gene in four population samples from the province of Córdoba, in Central Argentina, and to compare them with other worldwide populations. Methods: A total of 110 buccal swab samples from autoc...

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Autores principales: Tavella, María Pía, García, Angelina, Pauro, Maia, Demarchi, Dario, Nores, Rodrigo
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Wiley-liss, Div John Wiley & Sons Inc 2017
Materias:
ABO BLOOD GROUP SYSTEM
O1v542
ADMIXED POPULATIONS
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Otras Humanidades
HUMANIDADES
Acceso en línea:http://hdl.handle.net/11336/63014
http://suquia.ffyh.unc.edu.ar/handle/11336/63014
Aporte de:
Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC) de Universidad Nacional de Córdoba
id I10-R181-11336-63014
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-181
collection Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC)
language Inglés
topic ABO BLOOD GROUP SYSTEM
O1v542
ADMIXED POPULATIONS
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Otras Humanidades
Otras Humanidades
HUMANIDADES
spellingShingle ABO BLOOD GROUP SYSTEM
O1v542
ADMIXED POPULATIONS
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Otras Humanidades
Otras Humanidades
HUMANIDADES
Tavella, María Pía
García, Angelina
Pauro, Maia
Demarchi, Dario
Nores, Rodrigo
Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
topic_facet ABO BLOOD GROUP SYSTEM
O1v542
ADMIXED POPULATIONS
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Otras Humanidades
Otras Humanidades
HUMANIDADES
description Objectives: The aim of this study was to investigate the distribution of molecular polymorphisms of the ABO gene in four population samples from the province of Córdoba, in Central Argentina, and to compare them with other worldwide populations. Methods: A total of 110 buccal swab samples from autochthonous individuals of Córdoba were typified. Molecular characterization of the allelic variants was performed by the analysis of exons 6 and 7 of the ABO gene using PCR-RFLP analysis. Additionally, the Native American AIM O1v542 was characterized by direct sequencing. Results: The four Córdoba populations did not show significant geographic structure, although the frequency of the O1v542 haplotype, detected in all the populations studied, ranged from 0.019 to 0.222. The principal component analysis based on O allele distribution showed that the populations from Córdoba clustered close to the admixed populations of Santiago and Mexico City, and at intermediate distances between European and Native American populations, while being distant from the African population. Conclusions: The results demonstrate that the analysis of the ABO system constitutes a useful tool for the study of the genetic structure and evolutionary history of human populations, reflecting accurately the relative contribution of parental continental contribution to the gene pool of admixed populations.
format Artículo
Artículo
publishedVersion
author Tavella, María Pía
García, Angelina
Pauro, Maia
Demarchi, Dario
Nores, Rodrigo
author_facet Tavella, María Pía
García, Angelina
Pauro, Maia
Demarchi, Dario
Nores, Rodrigo
author_sort Tavella, María Pía
title Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
title_short Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
title_full Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
title_fullStr Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
title_full_unstemmed Molecular polymorphisms of the ABO locus as informative markers of ancestry in Central Argentina
title_sort molecular polymorphisms of the abo locus as informative markers of ancestry in central argentina
publisher Wiley-liss, Div John Wiley & Sons Inc
publishDate 2017
url http://hdl.handle.net/11336/63014
http://suquia.ffyh.unc.edu.ar/handle/11336/63014
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