Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

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Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little i...

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Detalles Bibliográficos
Autores principales: Luisi, Pierre, García, Angelina, Berros, Juan Manuel, Motti, Josefina María Brenda, Demarchi, Dario, Alfaro Gómez, Emma Laura, Aquilano, Eliana Anahi, Argüelles, Carina Francisca, Avena, Sergio Alejandro, Bailliet, Graciela, Beltramo, Julieta, Bravi, Claudio Marcelo, Cuello, Mariela Vanesa, Dejean, Cristina Beatriz, Dipierri, Jose Edgardo, Jurado Medina, Laura Smeldy, Lanata, Jose Luis, Muzzio, Marina, Parolin, María Laura, Pauro, Maia, Paz Sepúlveda, Paula Beatriz, Rodríguez Golpe, Daniela Carmen, Santos, María Rita, Schwab, Marisol Elisabet, Silvero, Natalia, Zubrzycki, Jeremías Enrique, Ramallo, Virginia, Dopazo, Hernán Javier
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Public Library of Science 2020
Materias:
Ancestry
Native American
Argentina
Genética y Herencia
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Acceso en línea:http://hdl.handle.net/11336/128640
http://suquia.ffyh.unc.edu.ar/handle/11336/128640
Aporte de:
Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC) de Universidad Nacional de Córdoba
Descripción
Sumario:Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.

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