NAT2 gene diversity and its evolutionary trajectory in the Americas

N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native Ameri...

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Autores principales:	Bisso Machado, R., Ramallo, Virginia, Paixão Côrtes, V. R., Acuña Alonzo, V., Demarchi, Dario, Sandoval, J. R. S., Granara, A. A. S., Salzano, F. M., Hünemeier, T., Bortolini, M. C.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Macmillan Publishers 2016
Materias:	N-ACETYLTRANSFERASE 2 AMERINDIANS HUNTER AGRICULTURALISTS GATHERERS Genética y Herencia Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS
Acceso en línea:	http://hdl.handle.net/11336/11705 http://suquia.ffyh.unc.edu.ar/handle/11336/11705
Aporte de:	Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC) de Universidad Nacional de Córdoba

id	I10-R181-11336-11705
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institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-181
collection	Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC)
language	Inglés
topic	N-ACETYLTRANSFERASE 2 AMERINDIANS HUNTER AGRICULTURALISTS GATHERERS Genética y Herencia Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS
spellingShingle	N-ACETYLTRANSFERASE 2 AMERINDIANS HUNTER AGRICULTURALISTS GATHERERS Genética y Herencia Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS Bisso Machado, R. Ramallo, Virginia Paixão Côrtes, V. R. Acuña Alonzo, V. Demarchi, Dario Sandoval, J. R. S. Granara, A. A. S. Salzano, F. M. Hünemeier, T. Bortolini, M. C. NAT2 gene diversity and its evolutionary trajectory in the Americas
topic_facet	N-ACETYLTRANSFERASE 2 AMERINDIANS HUNTER AGRICULTURALISTS GATHERERS Genética y Herencia Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS
description	N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT24, the most frequent haplotypes are NAT25B (35.95%) in hunter-gatherers and NAT27B (20.61%) and NAT25B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ~ 44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal.
format	Artículo Artículo publishedVersion
author	Bisso Machado, R. Ramallo, Virginia Paixão Côrtes, V. R. Acuña Alonzo, V. Demarchi, Dario Sandoval, J. R. S. Granara, A. A. S. Salzano, F. M. Hünemeier, T. Bortolini, M. C.
author_facet	Bisso Machado, R. Ramallo, Virginia Paixão Côrtes, V. R. Acuña Alonzo, V. Demarchi, Dario Sandoval, J. R. S. Granara, A. A. S. Salzano, F. M. Hünemeier, T. Bortolini, M. C.
author_sort	Bisso Machado, R.
title	NAT2 gene diversity and its evolutionary trajectory in the Americas
title_short	NAT2 gene diversity and its evolutionary trajectory in the Americas
title_full	NAT2 gene diversity and its evolutionary trajectory in the Americas
title_fullStr	NAT2 gene diversity and its evolutionary trajectory in the Americas
title_full_unstemmed	NAT2 gene diversity and its evolutionary trajectory in the Americas
title_sort	nat2 gene diversity and its evolutionary trajectory in the americas
publisher	Macmillan Publishers
publishDate	2016
url	http://hdl.handle.net/11336/11705 http://suquia.ffyh.unc.edu.ar/handle/11336/11705
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bdutipo_str	Repositorios
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NAT2 gene diversity and its evolutionary trajectory in the Americas

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