Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions

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Previous works of our team had shown clinical data which suggest that Chronic Mechanical Irritation (CMI) could be a risk factor for Oral Cancer (OC). However, there are no known patterns of biomarkers in CMI indicative of cellular malignancy. The aim of this study was to identify a biomarker patter...

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Autores principales: Gilligan, Gerardo Marcelo, Piemonte, Eduardo David, Panico, René Luis, Di Tada, Cecilia E., Brunotto, Mabel
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2022
Materias:
Cáncer bucal
Inflamación endodóntica
Inmunohistoquímica
Acceso en línea:http://hdl.handle.net/11086/23671
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-23671
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Cáncer bucal
Inflamación endodóntica
Inmunohistoquímica
spellingShingle Cáncer bucal
Inflamación endodóntica
Inmunohistoquímica
Gilligan, Gerardo Marcelo
Piemonte, Eduardo David
Panico, René Luis
Di Tada, Cecilia E.
Brunotto, Mabel
Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
topic_facet Cáncer bucal
Inflamación endodóntica
Inmunohistoquímica
description Previous works of our team had shown clinical data which suggest that Chronic Mechanical Irritation (CMI) could be a risk factor for Oral Cancer (OC). However, there are no known patterns of biomarkers in CMI indicative of cellular malignancy. The aim of this study was to identify a biomarker pattern of differentiation (Ck19) and cell proliferation (Ki67) in CMI-associated lesions, similar to those observed in OC. Methods: a Cross-sectional study of adult patients (n = 61), both sexes, with lesions associated with CMI according to the Piemonte et al criteria. CK19 and Ki67 Immunohistochemistry were carried out in biopsies of both types of lesions and the patterns were described according to previous publications of Safadi and Argyris. The present study was approved by Ethics Committee of the College of Dentistry, Universidad Nacional de Cordoba. Results: Ki67 overexpression and a CK19 focal pattern with strong intensity in basal and parabasal cells were observed in CMI lesions, similar to that observed in OC. Conclusion: there is no scientific literature on biomarker patterns of Oral CMI. Therefore, the described pattern, particularly Ck19, is novel and could be indicative of the relationship between the presence of CMI and oral carcinogenesis.
format conferenceObject
author Gilligan, Gerardo Marcelo
Piemonte, Eduardo David
Panico, René Luis
Di Tada, Cecilia E.
Brunotto, Mabel
author_facet Gilligan, Gerardo Marcelo
Piemonte, Eduardo David
Panico, René Luis
Di Tada, Cecilia E.
Brunotto, Mabel
author_sort Gilligan, Gerardo Marcelo
title Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
title_short Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
title_full Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
title_fullStr Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
title_full_unstemmed Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions
title_sort oral carcinogenesis biomarkers in oral chronic mechanical irritation-associated lesions
publishDate 2022
url http://hdl.handle.net/11086/23671
work_keys_str_mv AT gilligangerardomarcelo oralcarcinogenesisbiomarkersinoralchronicmechanicalirritationassociatedlesions
AT piemonteeduardodavid oralcarcinogenesisbiomarkersinoralchronicmechanicalirritationassociatedlesions
AT panicoreneluis oralcarcinogenesisbiomarkersinoralchronicmechanicalirritationassociatedlesions
AT ditadaceciliae oralcarcinogenesisbiomarkersinoralchronicmechanicalirritationassociatedlesions
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bdutipo_str Repositorios
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