Risk Polymorphisms in oral Leukoplakia: a Systematic Review

Introduction The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma. Purpose Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal wa...

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Autores principales: Bono, Alejandra, Zárate, Ana María, Don, Julieta, Barra, José Luis, Brunotto, Mabel
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2022
Materias:
Revisión sistemática
Leucoplasia bucal
Carcinoma de células escamosas
Acceso en línea:http://hdl.handle.net/11086/22697
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-22697
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Revisión sistemática
Leucoplasia bucal
Carcinoma de células escamosas
spellingShingle Revisión sistemática
Leucoplasia bucal
Carcinoma de células escamosas
Bono, Alejandra
Zárate, Ana María
Don, Julieta
Barra, José Luis
Brunotto, Mabel
Risk Polymorphisms in oral Leukoplakia: a Systematic Review
topic_facet Revisión sistemática
Leucoplasia bucal
Carcinoma de células escamosas
description Introduction The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma. Purpose Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL. Method Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. Results The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL. Conclusions According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk.
format conferenceObject
author Bono, Alejandra
Zárate, Ana María
Don, Julieta
Barra, José Luis
Brunotto, Mabel
author_facet Bono, Alejandra
Zárate, Ana María
Don, Julieta
Barra, José Luis
Brunotto, Mabel
author_sort Bono, Alejandra
title Risk Polymorphisms in oral Leukoplakia: a Systematic Review
title_short Risk Polymorphisms in oral Leukoplakia: a Systematic Review
title_full Risk Polymorphisms in oral Leukoplakia: a Systematic Review
title_fullStr Risk Polymorphisms in oral Leukoplakia: a Systematic Review
title_full_unstemmed Risk Polymorphisms in oral Leukoplakia: a Systematic Review
title_sort risk polymorphisms in oral leukoplakia: a systematic review
publishDate 2022
url http://hdl.handle.net/11086/22697
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AT donjulieta riskpolymorphismsinoralleukoplakiaasystematicreview
AT barrajoseluis riskpolymorphismsinoralleukoplakiaasystematicreview
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