Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha

Background: Breast cancer (BC) is the most common tumour among women and 75% of BC are estrogen receptor (ER)dependent. In particular, ERα promotes tumour growth, while ERβ has an anti-proliferative effect [1]. Epidemiological data have linked ω-3 polyunsaturated fatty acid (PUFA) consumption to...

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Autores principales: Vara Messler, Marianela, Pasqualini, María Eugenia, Comba, Andrea, Toniolo, Alicia, Trenti, Annalisa, Quiroga, Patricia, Valentich, Mirta Ana, Bolego, Chiara
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2022
Materias:
Syngenic
Breast adenocarcinoma
Receptor alpha
Acceso en línea:http://hdl.handle.net/11086/22318
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-22318
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Syngenic
Breast adenocarcinoma
Receptor alpha
spellingShingle Syngenic
Breast adenocarcinoma
Receptor alpha
Vara Messler, Marianela
Pasqualini, María Eugenia
Comba, Andrea
Toniolo, Alicia
Trenti, Annalisa
Quiroga, Patricia
Valentich, Mirta Ana
Bolego, Chiara
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
topic_facet Syngenic
Breast adenocarcinoma
Receptor alpha
description Background: Breast cancer (BC) is the most common tumour among women and 75% of BC are estrogen receptor (ER)dependent. In particular, ERα promotes tumour growth, while ERβ has an anti-proliferative effect [1]. Epidemiological data have linked ω-3 polyunsaturated fatty acid (PUFA) consumption to lower incidence of BC and several experimental studies showed the anti-proliferative effects of ω-3 fish oil in different tumour models [2,3]. Chia seed oil is rich in α-linolenic acid (ALA 18:3 ω-3), while corn oil is rich in linoleic acid (LA 18:2 ω-6), precursors of eicosapentaenoic acid (EPA) and arachidonic acid (AA), respectively. Based on substrate availability, these FAs give rise to different eicosanoid signatures with opposite effects in cancer [4]. ω-3 PUFAs generate both anti-inflammatory prostanoids and reactive oxygen species (ROS), which in turn could affect NF-κB. Indeed, NF-κB belongs to a family of transcription factors with a key role in inflammation and oxidative stress, but its role in tumour development is still controversial [5]. The aim of the study was to determine possible processes that are activated by dietary lipids regulating BC growth and metastasis.
format conferenceObject
author Vara Messler, Marianela
Pasqualini, María Eugenia
Comba, Andrea
Toniolo, Alicia
Trenti, Annalisa
Quiroga, Patricia
Valentich, Mirta Ana
Bolego, Chiara
author_facet Vara Messler, Marianela
Pasqualini, María Eugenia
Comba, Andrea
Toniolo, Alicia
Trenti, Annalisa
Quiroga, Patricia
Valentich, Mirta Ana
Bolego, Chiara
author_sort Vara Messler, Marianela
title Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
title_short Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
title_full Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
title_fullStr Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
title_full_unstemmed Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
title_sort effects of ω-3 pufa-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
publishDate 2022
url http://hdl.handle.net/11086/22318
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