Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
Controversy exists over the maternal–fetal passage of fluoride (F-). This work sought to explore different aspects of F-metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F-accumulation in bones and teeth and growth morphometric parameters in the off...
Guardado en:
| Autores principales: | , , , , , , |
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| Formato: | conferenceObject |
| Lenguaje: | Inglés |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/11086/21543 |
| Aporte de: |
| Sumario: | Controversy exists over the maternal–fetal passage of fluoride (F-). This work
sought to explore different aspects of F-metabolism during pregnancy and lactation in
mothers and offspring. The specific aim was to study F-accumulation in bones and
teeth and growth morphometric parameters in the offspring of mothers exposed to
high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups
of mothers were used: a) control mothers (0.3 mg/L F-); b) treated mothers (50 mg/L F-).
The treatment was performed during the period of pregnancy and lactation. All animals
were euthanized and the upper and lower jaw and tibia of mothers were removed for the
determination of F-. Incisor diameter, mandibular growth and tibia length were
determined on RX digitalized images. Results were analyzed by Student t test.
Accumulated F-content was significantly higher in the jaws (p b 0.05), incisor (p b 0.01)
and tibia (p b 0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old
pups born to treated mothers, F-content in jaws did not differ from the control. However,
in 21-day-old pups, accumulated F- was higher (p b 0.05). No differences were found in Fcontent or growth parameters in tibia of the offspring in all studied groups. Lower incisor
diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F-compared to
their controls (p b 0.01). The results suggest that F-accumulation in calcified tissues of the
offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur
through milk during lactation. Further studies would help to elucidate the mechanism of
this process. |
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