Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats

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Controversy exists over the maternal–fetal passage of fluoride (F-). This work sought to explore different aspects of F-metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F-accumulation in bones and teeth and growth morphometric parameters in the off...

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Autores principales: Interlandi, Victoria, Fontanetti, Pablo Alejandro, Ponce, Rubén Hugo, Tirao, Germán Alfredo, Rigalli, Alfredo, Gallará, Raquel Vivian, Centeno, Viviana Andrea
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2021
Materias:
Fluoruros
Fluorosis dental
Exposición materna
Acceso en línea:http://hdl.handle.net/11086/21543
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-21543
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Fluoruros
Fluorosis dental
Exposición materna
spellingShingle Fluoruros
Fluorosis dental
Exposición materna
Interlandi, Victoria
Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
topic_facet Fluoruros
Fluorosis dental
Exposición materna
description Controversy exists over the maternal–fetal passage of fluoride (F-). This work sought to explore different aspects of F-metabolism during pregnancy and lactation in mothers and offspring. The specific aim was to study F-accumulation in bones and teeth and growth morphometric parameters in the offspring of mothers exposed to high levels of F- in drinking water. Pups aged 10-, 15- and 21-day-old from 2 groups of mothers were used: a) control mothers (0.3 mg/L F-); b) treated mothers (50 mg/L F-). The treatment was performed during the period of pregnancy and lactation. All animals were euthanized and the upper and lower jaw and tibia of mothers were removed for the determination of F-. Incisor diameter, mandibular growth and tibia length were determined on RX digitalized images. Results were analyzed by Student t test. Accumulated F-content was significantly higher in the jaws (p b 0.05), incisor (p b 0.01) and tibia (p b 0.05) of mothers exposed to F- compared to control. In 10- and 15-day-old pups born to treated mothers, F-content in jaws did not differ from the control. However, in 21-day-old pups, accumulated F- was higher (p b 0.05). No differences were found in Fcontent or growth parameters in tibia of the offspring in all studied groups. Lower incisor diameter was lower in 21-day-old pups born to mothers exposed 50 mg/L F-compared to their controls (p b 0.01). The results suggest that F-accumulation in calcified tissues of the offspring is lower than in maternal tissues. The passage of F- mother-offspring could occur through milk during lactation. Further studies would help to elucidate the mechanism of this process.
format conferenceObject
author Interlandi, Victoria
Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
author_facet Interlandi, Victoria
Fontanetti, Pablo Alejandro
Ponce, Rubén Hugo
Tirao, Germán Alfredo
Rigalli, Alfredo
Gallará, Raquel Vivian
Centeno, Viviana Andrea
author_sort Interlandi, Victoria
title Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_short Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_full Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_fullStr Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_full_unstemmed Effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
title_sort effect of pre- and post-natal exposure to fluoride on fluorosis indicators in offspring of rats
publishDate 2021
url http://hdl.handle.net/11086/21543
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