Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers

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Background: Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers (CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in Oral Medicine. Although these conditions may re-flect a benign nature, some authors have proposed its relationship with malig...

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Autores principales: Gilligan, Gerardo Marcelo, Panico, René Luis, Di Tada, Cecilia, Piemonte, Eduardo David, Brunotto, Mabel Noemí
Formato: article
Lenguaje:Inglés
Publicado: 2021
Materias:
Ck19
Ki67
Oral Cancer
Chronic Traumatic Ulcer
Chronic Mechanical Irritation
Acceso en línea:http://hdl.handle.net/11086/20178
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-20178
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Ck19
Ki67
Oral Cancer
Chronic Traumatic Ulcer
Chronic Mechanical Irritation
spellingShingle Ck19
Ki67
Oral Cancer
Chronic Traumatic Ulcer
Chronic Mechanical Irritation
Gilligan, Gerardo Marcelo
Panico, René Luis
Di Tada, Cecilia
Piemonte, Eduardo David
Brunotto, Mabel Noemí
Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
topic_facet Ck19
Ki67
Oral Cancer
Chronic Traumatic Ulcer
Chronic Mechanical Irritation
description Background: Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers (CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in Oral Medicine. Although these conditions may re-flect a benign nature, some authors have proposed its relationship with malignant transformation. Currently, there are scarce investigations that evaluate biomarkers within CTU. The aim of this study was to evaluate cell differentiation and proliferation biomarkers patterns of CTU and OSCC through recognized markers such as cytokeratin 19 and Ki67 and correlate it with clinical features of both groups of patients. Material and Methods: A Cross-sectional study of adult patients (n=79), both sexes, attended at Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba. The patients were classified into two groups: CTU (n=41), and OSCC (n=38). A subset of specimens were immunolabeled with Ki67 and Ck19. Results: The population consisted of 51.9% male and 48.1% female, with an average of 57.0 ± 13.9. years (OSCC group) and 60.9 ± 14.9 years (CTU group). OSCC group presented higher scores for both biomarkers (Ki67 and Ck19), but only there were differences statistically significant for Ki67 (p=0.032). 25% of non-healing CTU were positive with medium scores of Ck19 and showed an immunohistochemical profile similar to OSCC. The lateral tongue was the most frequent site in both groups. Conclusion: The altered immunohistochemical pattern found in many specimens of CTU was also observed in OSCC. The tongue border presents physiological conditions that could offer a suitable environment for the development of neoplastic events associated with CMI. Further studies are needed to understand the underlying mechanisms that could link oral non-healing ulcers with early malignant changes.
format article
author Gilligan, Gerardo Marcelo
Panico, René Luis
Di Tada, Cecilia
Piemonte, Eduardo David
Brunotto, Mabel Noemí
author_facet Gilligan, Gerardo Marcelo
Panico, René Luis
Di Tada, Cecilia
Piemonte, Eduardo David
Brunotto, Mabel Noemí
author_sort Gilligan, Gerardo Marcelo
title Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
title_short Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
title_full Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
title_fullStr Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
title_full_unstemmed Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
title_sort clinical and immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
publishDate 2021
url http://hdl.handle.net/11086/20178
work_keys_str_mv AT gilligangerardomarcelo clinicalandimmunohistochemicalepithelialprofileofnonhealingchronictraumaticulcers
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AT ditadacecilia clinicalandimmunohistochemicalepithelialprofileofnonhealingchronictraumaticulcers
AT piemonteeduardodavid clinicalandimmunohistochemicalepithelialprofileofnonhealingchronictraumaticulcers
AT brunottomabelnoemi clinicalandimmunohistochemicalepithelialprofileofnonhealingchronictraumaticulcers
bdutipo_str Repositorios
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