Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016

Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integr...

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Autores principales:	Kembro, Jackeline Melissa, Cortassa, Sonia, Lloyd, David, Sollott, Steven, Aon, Miguel
Formato:	dataSet
Lenguaje:	Español
Publicado:	2020
Materias:	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes
Acceso en línea:	https://doi.org/10.6084/m9.figshare.7117907.v1 http://hdl.handle.net/11086/17030
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R14111086-17030
record_format	dspace
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Español
topic	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes
spellingShingle	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
topic_facet	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress enzymes
description	Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms.All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG.
format	dataSet
author	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_facet	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_sort	Kembro, Jackeline Melissa
title	Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
title_short	Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
title_full	Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
title_fullStr	Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
title_full_unstemmed	Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016
title_sort	chaotic fluctuations in mitochondrial function under oxidative stress. sod2 concentrations of 0.016
publishDate	2020
url	https://doi.org/10.6084/m9.figshare.7117907.v1 http://hdl.handle.net/11086/17030
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bdutipo_str	Repositorios
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Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016

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