Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM

Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equat...

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Autores principales: Kembro, Jackelyn Melissa, Cortassa, Sonia, Lloyd, David, Sollot, Steven, Aon, Miguel
Formato: dataSet
Lenguaje:Inglés
Publicado: 2020
Materias:
Animal Physiology - Systems
Molecular Biology
Superoxide dismutase activity
Respiration
Oxidative stress effect
Oxidative stress enzymes
https://purl.org/becyt/ford/4.3
Acceso en línea:http://hdl.handle.net/11086/16912
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-16912
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Animal Physiology - Systems
Molecular Biology
Superoxide dismutase activity
Respiration
Oxidative stress effect
Oxidative stress enzymes
https://purl.org/becyt/ford/4.3
spellingShingle Animal Physiology - Systems
Molecular Biology
Superoxide dismutase activity
Respiration
Oxidative stress effect
Oxidative stress enzymes
https://purl.org/becyt/ford/4.3
Kembro, Jackelyn Melissa
Cortassa, Sonia
Lloyd, David
Sollot, Steven
Aon, Miguel
Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
topic_facet Animal Physiology - Systems
Molecular Biology
Superoxide dismutase activity
Respiration
Oxidative stress effect
Oxidative stress enzymes
https://purl.org/becyt/ford/4.3
description Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. The solutions were then evaluated with the function deval.m in MATLAB R2017a to obtain a time series with constant sampling frequency at 1ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column:1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG
format dataSet
author Kembro, Jackelyn Melissa
Cortassa, Sonia
Lloyd, David
Sollot, Steven
Aon, Miguel
author_facet Kembro, Jackelyn Melissa
Cortassa, Sonia
Lloyd, David
Sollot, Steven
Aon, Miguel
author_sort Kembro, Jackelyn Melissa
title Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
title_short Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
title_full Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
title_fullStr Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
title_full_unstemmed Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0216733 mM
title_sort chaotic fluctuations in mitochondrial function under oxidative stress. sod2 concentrations of 0.0216733 mm
publishDate 2020
url http://hdl.handle.net/11086/16912
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AT lloyddavid chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm
AT sollotsteven chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm
AT aonmiguel chaoticfluctuationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00216733mm
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