Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM

Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kembro, Jackelyn Melissa, Cortassa, Sonia, Lloyd, David, Sollot, Steven, Aon, Miguel
Formato:	dataSet
Lenguaje:	Inglés
Publicado:	2020
Materias:	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Bioenergetics model Oxidative stress effects Oxidative stress enzymes https://purl.org/becyt/ford/4.3
Acceso en línea:	http://hdl.handle.net/11086/16807
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R14111086-16807
record_format	dspace
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Bioenergetics model Oxidative stress effects Oxidative stress enzymes https://purl.org/becyt/ford/4.3
spellingShingle	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Bioenergetics model Oxidative stress effects Oxidative stress enzymes https://purl.org/becyt/ford/4.3 Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
topic_facet	Animal Physiology - Biophysics Animal Physiology - Systems Biophysics Mitochondria Bioenergetics model Oxidative stress effects Oxidative stress enzymes https://purl.org/becyt/ford/4.3
description	Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG.
format	dataSet
author	Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel
author_facet	Kembro, Jackelyn Melissa Cortassa, Sonia Lloyd, David Sollot, Steven Aon, Miguel
author_sort	Kembro, Jackelyn Melissa
title	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
title_short	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
title_full	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
title_fullStr	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
title_full_unstemmed	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM
title_sort	periodic oscillations in mitochondrial function under oxidative stress. sod2 concentrations of 0.0164 mm
publishDate	2020
url	http://hdl.handle.net/11086/16807
work_keys_str_mv	AT kembrojackelynmelissa periodicoscillationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00164mm AT cortassasonia periodicoscillationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00164mm AT lloyddavid periodicoscillationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00164mm AT sollotsteven periodicoscillationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00164mm AT aonmiguel periodicoscillationsinmitochondrialfunctionunderoxidativestresssod2concentrationsof00164mm
bdutipo_str	Repositorios
_version_	1764820393581871107

Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM

Ejemplares similares