Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats

Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.

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Detalles Bibliográficos
Autores principales: Macchione, Ana Fabiola, Trujillo, Veronica, Anastasia, Agustín, Molina, Juan Carlos
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2025
Materias:
Serotonina
Raphe
Etanol
Medicina
Acceso en línea:http://hdl.handle.net/11086/555206
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-555206
record_format dspace
spelling I10-R141-11086-5552062025-03-21T14:48:00Z Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats Macchione, Ana Fabiola Trujillo, Veronica Anastasia, Agustín Molina, Juan Carlos Serotonina Raphe Etanol Medicina Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicologías; Argentina. Fil: Trujillo, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Anastasia, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicologías; Argentina. Ethanol is the most commonly abused substance that impacts the humans during early ontogeny (gestation and lactation). Ethanol effects include alterations in brain development, learning and memory, cognitive abilities and neurovegetative functions such as breathing. A major target of ethanol in the central nervous system is the serotonin (5HT) neurons involved on the respiratory regulation. Preclinical studies employing chronic and severe ethanol consumption models during pregnancy and lactation, showed a decrease in the number of 5HT-neurons and 5HT levels in the raphe system. However, the status of the serotonergic system in animal models with moderate and neonatal ethanol exposure are understudied. Thus, the main goal of this study was to evaluate 5HT levels in the raphe obscurus (ROb) nucleus in neonate rats, as a function of moderate ethanol or vehicle exposure (2.0 or 0.0g/kg, intragastrically) at postnatal days (PD) 3, 5 and 7. At PD 9, pups were intoxicated or vehicle administrated. Ninety minutes after, all pups were sacrificed and 5HT levels were immunodetected at the ROb. A significant reduction of 5HT levels was observed in pups exposed to ethanol for the first time at PD 9 and vehicle-pretreated at PDs 3, 5 & 7. Interestingly, a similar decrease in 5HT levels was also found in ethanol-pretreated pups evaluated under sobriety at PD 9. These results indicate a profound effect of ethanol upon on 5HT levels at ROb, nucleus specifically involved in breathing regulation. These data indicate that perinatal ethanol exposure is enough to alter 5HT levels in the Rob. These results became important when associating the function of the ROb on respiratory response and breathing disturbances commonly observed in neonate rats and humans, such as Sudden Infant Death Syndrome. https://drive.google.com/file/d/1ANKFVSKnbUO3PJX7jV94t_L1nTDKgU-d/view Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicologías; Argentina. Fil: Trujillo, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Anastasia, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicologías; Argentina. Neurociencias (incluye Psicofiosiología) 2025-03-21T14:47:24Z 2025-03-21T14:47:24Z 2017 conferenceObject 1669-9106 http://hdl.handle.net/11086/555206 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso; Electrónico y/o Digital
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Serotonina
Raphe
Etanol
Medicina
spellingShingle Serotonina
Raphe
Etanol
Medicina
Macchione, Ana Fabiola
Trujillo, Veronica
Anastasia, Agustín
Molina, Juan Carlos
Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
topic_facet Serotonina
Raphe
Etanol
Medicina
description Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.
format conferenceObject
author Macchione, Ana Fabiola
Trujillo, Veronica
Anastasia, Agustín
Molina, Juan Carlos
author_facet Macchione, Ana Fabiola
Trujillo, Veronica
Anastasia, Agustín
Molina, Juan Carlos
author_sort Macchione, Ana Fabiola
title Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
title_short Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
title_full Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
title_fullStr Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
title_full_unstemmed Brief ethanol doses modifies 5HT levels at Raphe obscurus in neonate rats
title_sort brief ethanol doses modifies 5ht levels at raphe obscurus in neonate rats
publishDate 2025
url http://hdl.handle.net/11086/555206
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AT anastasiaagustin briefethanoldosesmodifies5htlevelsatrapheobscurusinneonaterats
AT molinajuancarlos briefethanoldosesmodifies5htlevelsatrapheobscurusinneonaterats
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