Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs

2023. Impact factor: 2.7

Guardado en:
Detalles Bibliográficos
Autores principales: Mosconi, Giuliana, Formica, María Lina, Palma, Santiago D., Rojas, Ricardo
Otros Autores: https://orcid.org/0000-0001-7225-0998
Formato: publishedVersion article
Lenguaje:Inglés
Publicado: Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2024
Materias:
Drug delivery
Layered double hydroxides (LDHs)
Rheological properties
Sustained release
Mucoadhesion
Acceso en línea:http://hdl.handle.net/11086/553238
https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c
https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth
https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf
https://doi.org/10.1039/D3NJ04434C
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-553238
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Drug delivery
Layered double hydroxides (LDHs)
Rheological properties
Sustained release
Mucoadhesion
spellingShingle Drug delivery
Layered double hydroxides (LDHs)
Rheological properties
Sustained release
Mucoadhesion
Mosconi, Giuliana
Formica, María Lina
Palma, Santiago D.
Rojas, Ricardo
Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
topic_facet Drug delivery
Layered double hydroxides (LDHs)
Rheological properties
Sustained release
Mucoadhesion
description 2023. Impact factor: 2.7
author2 https://orcid.org/0000-0001-7225-0998
author_facet https://orcid.org/0000-0001-7225-0998
Mosconi, Giuliana
Formica, María Lina
Palma, Santiago D.
Rojas, Ricardo
format publishedVersion
article
author Mosconi, Giuliana
Formica, María Lina
Palma, Santiago D.
Rojas, Ricardo
author_sort Mosconi, Giuliana
title Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
title_short Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
title_full Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
title_fullStr Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
title_full_unstemmed Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
title_sort carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs
publisher Royal Society of Chemistry and the Centre National de la Recherche Scientifique
publishDate 2024
url http://hdl.handle.net/11086/553238
https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c
https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth
https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf
https://doi.org/10.1039/D3NJ04434C
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spelling I10-R141-11086-5532382024-08-10T06:25:53Z Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs Mosconi, Giuliana Formica, María Lina Palma, Santiago D. Rojas, Ricardo https://orcid.org/0000-0001-7225-0998 https://orcid.org/0000-0003-3161-6425 https://orcid.org/0000-0003-2767-9087 https://orcid.org/0000-0001-5826-2036 Drug delivery Layered double hydroxides (LDHs) Rheological properties Sustained release Mucoadhesion 2023. Impact factor: 2.7 info:eu-repo/semantics/publishedVersion Fil: Mosconi, Giuliana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Mosconi, Giuliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Fil: Formica, María Lina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Palma, Santiago D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palma Santiago D. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Rojas, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rojas, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Drug delivery to ocular tissues is mainly hindered by anatomical and physiological barriers that diminish their bioavailability. In this work, layered double hydroxides (LDHs) intercalated with non-steroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, and ketorolac) were incorporated into carboxymethylcellulose (CMC) dispersions with the aim of adjusting their rheological properties, producing sustained release, and inducing mucoadhesive properties. Pure NSAID-intercalated LDHs (LDH-NSAID) with high drug loading were obtained. The obtained particles showed high aggregation and positive surface charges, which allowed interaction with the negatively charged groups of CMC. Isotonic 1% CMC and 1% LDH-NSAID (w/w) dispersions behaved as viscous, shear-thinning fluids, although a stronger interaction with ketoprofen led to more gel-like behavior. Also, CMC/LDH-NSAID dispersions exhibited a more sustained drug release than that achieved with analogous formulations containing pure drugs, and the modeling of the profile indicated that the release rate was mainly determined by the anion exchange of the intercalated NSAID. Finally, the formulations showed strong mucoadhesion capacity, as they produce significant changes in the zeta potential of mucin dispersions. Further optimization of the particle size and surface properties of the particles is required to modulate the release profile and to enhance the rheological properties of these CMC/LDH-based formulations. info:eu-repo/semantics/publishedVersion Fil: Mosconi, Giuliana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Mosconi, Giuliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. Fil: Formica, María Lina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Palma, Santiago D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina. Fil: Palma Santiago D. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Fil: Rojas, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rojas, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Fisicoquímica de Córdoba; Argentina. 2024-08-09T20:11:47Z 2024-08-09T20:11:47Z 2023-11-24 article Mosconi, G., Formica, M. L., Palma, S. D., & Rojas, R. (2024). Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs. New Journal of Chemistry, 48(1), 406-415. http://hdl.handle.net/11086/553238 1369-9261 https://pubs.rsc.org/en/content/articlehtml/2024/nj/d3nj04434c https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj04434c/unauth https://www.rsc.org/suppdata/d3/nj/d3nj04434c/d3nj04434c1.pdf https://doi.org/10.1039/D3NJ04434C eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Royal Society of Chemistry and the Centre National de la Recherche Scientifique

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