Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles

Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina.

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Detalles Bibliográficos
Autores principales: Chamorro Cañon, J. David, Luna, M. Alejandra, Sabini, M. Carola, Molina, Patricia G., Correa, Mariano
Otros Autores: https://orcid.org/0000-0001-7493-8964
Formato: acceptedVersion article
Lenguaje:Inglés
Publicado: 2024
Materias:
Assays
Cells
Encapsulation
Nanocarriers
Vesicles
Acceso en línea:http://hdl.handle.net/11086/552898
https://pubs.acs.org/journal/jpcbfk
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-552898
record_format dspace
spelling I10-R141-11086-5528982024-07-27T06:21:27Z Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles Chamorro Cañon, J. David Luna, M. Alejandra Sabini, M. Carola Molina, Patricia G. Correa, Mariano https://orcid.org/0000-0001-7493-8964 https://orcid.org/0000-0002-1728-3620 Assays Cells Encapsulation Nanocarriers Vesicles info:eu-repo/semantics/acceptedVersion Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Luna, M. Alejandra. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Sabini, María Carola. Universidad Nacional de Río Cuarto; Argentina. Fil: Sabini, María Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Molina, Patricia G. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Correa, Mariano. niversidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. 5-Fluorouracil (5-FU) is an antineoplastic agent known for its low bioavailability and limited cellular penetration, often resulting in adverse effects on healthy cells. Thus, finding vehicles that enhance bioavailability, enable controlled release, and mitigate adverse effects is crucial. The study focuses on encapsulating 5-FU within soy lecithin vesicles (SLVs) and assessing its impact on the carrier’s properties and functionality. Results show that incorporating 5-FU does not affect SLVs’ size or polydispersity, even postlyophilization. Liberation of 5-FU from SLVs requires system disruption rather than spontaneous release, with an encapsulation efficiency of approximately 43% determined using Square Wave Voltammetry. Cytotoxicity assays on colorectal cancer cells reveal SLV-based delivery’s significant efficacy, surpassing free drug solution effects with 45% cell viability after 72 h vs 73% viability. The research addresses 5-FU’s limited bioavailability by creating a biocompatible nanocarrier for efficient drug delivery, highlighting SLVs as promising for targeted cancer therapy due to sustained antiproliferative effects and improved cellular uptake. The study underscores the importance of tailored drug delivery systems in enhancing therapeutic outcomes and suggests SLV/5-FU formulations as a potential advancement in cancer treatment strategies. info:eu-repo/semantics/acceptedVersion Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Luna, M. Alejandra. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Sabini, María Carola. Universidad Nacional de Río Cuarto; Argentina. Fil: Sabini, María Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Molina, Patricia G. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Fil: Correa, Mariano. niversidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. 2024-07-25T19:40:44Z 2024-07-25T19:40:44Z 2024-05-29 article J. Phys. Chem. B 2024, 128, 22, 5427–5436 1520-6106 http://hdl.handle.net/11086/552898 1520-5207 https://pubs.acs.org/journal/jpcbfk eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Assays
Cells
Encapsulation
Nanocarriers
Vesicles
spellingShingle Assays
Cells
Encapsulation
Nanocarriers
Vesicles
Chamorro Cañon, J. David
Luna, M. Alejandra
Sabini, M. Carola
Molina, Patricia G.
Correa, Mariano
Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
topic_facet Assays
Cells
Encapsulation
Nanocarriers
Vesicles
description Fil: Chamorro Cañon, J. David. Universidad Nacional de Río Cuarto. Departamento de Química. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina.
author2 https://orcid.org/0000-0001-7493-8964
author_facet https://orcid.org/0000-0001-7493-8964
Chamorro Cañon, J. David
Luna, M. Alejandra
Sabini, M. Carola
Molina, Patricia G.
Correa, Mariano
format acceptedVersion
article
author Chamorro Cañon, J. David
Luna, M. Alejandra
Sabini, M. Carola
Molina, Patricia G.
Correa, Mariano
author_sort Chamorro Cañon, J. David
title Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
title_short Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
title_full Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
title_fullStr Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
title_full_unstemmed Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles
title_sort electrochemical characterization of the encapsulation and release of 5-fluorouracil in nanocarriers formed from soy lecithin vesicles
publishDate 2024
url http://hdl.handle.net/11086/552898
https://pubs.acs.org/journal/jpcbfk
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