RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans
Fil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.
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2024
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| Acceso en línea: | http://hdl.handle.net/11086/552733 |
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I10-R141-11086-5527332024-07-13T06:23:24Z RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans Varela, Gonzalo M. García, Beatriz A. Stroppa, María M. Chagas disease Triatoma infestans Pyrethroid resistance Cytochrome P450 NADPH cytochrome P450 reductase info:eu-repo/semantics/publishedVersion Fil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Varela, Gonzalo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. The enzyme NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochromes P450 activity. Gene expression analysis of cytochromes P450 and CPR in deltamethrin-resistant and susceptible populations revealed that P450s genes are involved in the development of insecticide resistance in Triatoma infestans. To clarify the role of cytochromes P450 in insecticide resistance, it was proposed to investigate the effect of CPR gene silencing by RNA interference (RNAi) in a pyrethroid resistant population of T. infestans. Silencing of the CPR gene showed a significant increase in susceptibility to deltamethrin in the population analysed. This result support the hypothesis that the metabolic process of detoxification mediated by cytochromes P450 contributes to the decreased deltamethrin susceptibility observed in the resistant strain of T. infestans. info:eu-repo/semantics/publishedVersion Fil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Varela, Gonzalo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. 2024-07-12T17:03:22Z 2024-07-12T17:03:22Z 2024-04 article Varela, G. M., García, B. A., & Stroppa, M. M. (2024). RNA interference of NADPHcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans. Acta Tropica, 252, 107149. http://hdl.handle.net/11086/552733 1873-6254 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-141 |
| collection |
Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Chagas disease Triatoma infestans Pyrethroid resistance Cytochrome P450 NADPH cytochrome P450 reductase |
| spellingShingle |
Chagas disease Triatoma infestans Pyrethroid resistance Cytochrome P450 NADPH cytochrome P450 reductase Varela, Gonzalo M. García, Beatriz A. Stroppa, María M. RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| topic_facet |
Chagas disease Triatoma infestans Pyrethroid resistance Cytochrome P450 NADPH cytochrome P450 reductase |
| description |
Fil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. |
| format |
publishedVersion article |
| author |
Varela, Gonzalo M. García, Beatriz A. Stroppa, María M. |
| author_facet |
Varela, Gonzalo M. García, Beatriz A. Stroppa, María M. |
| author_sort |
Varela, Gonzalo M. |
| title |
RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| title_short |
RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| title_full |
RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| title_fullStr |
RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| title_full_unstemmed |
RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans |
| title_sort |
rna interference of nadphsingle bondcytochrome p450 increased deltamethrin susceptibility in a resistant strain of the chagas disease vector triatoma infestans |
| publishDate |
2024 |
| url |
http://hdl.handle.net/11086/552733 |
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