Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase

This is a preprint article, it offers immediate access but has not been peer reviewed. All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open ac...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Romero, Jorge Miguel
Formato: publishedVersion article
Lenguaje:Español
Publicado: SSRN - Elsevier 2024
Materias:
Triosephosphate isomerase deficiency
X-ray crystallization
Stability
Flexibility
Acceso en línea:http://hdl.handle.net/11086/552351
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610
http://dx.doi.org/10.2139/ssrn.4848610
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-552351
record_format dspace
spelling I10-R141-11086-5523512024-06-21T06:25:36Z Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase Romero, Jorge Miguel Triosephosphate isomerase deficiency X-ray crystallization Stability Flexibility This is a preprint article, it offers immediate access but has not been peer reviewed. All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply. info:eu-repo/semantics/publishedVersion Fil: Romero, Jorge Miguel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto, Argentina. Fil: Romero, Jorge Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba, Argentina. Human triosephosphate isomerase G122R, also known as TPI-Manchester, is a thermolabile variant detected in a screening of more than 3,400 individuals from a population in Ann Arbor, Michigan. Here, the crystallographic structure of G122R was solved to determine the molecular basis of its thermal stability. Structural analysis revealed an increase in the flexibility of residues at the dimer interface, even though R122 is about 20 Å away, suggesting that long-range electrostatic interactions may play a key role in the mutation effect. info:eu-repo/semantics/publishedVersion Fil: Romero, Jorge Miguel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto, Argentina. Fil: Romero, Jorge Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba, Argentina. 2024-06-20T18:58:59Z 2024-06-20T18:58:59Z 2024-05-30 article Romero, Jorge Miguel, Structural Analysis of the Tpi-Manchester, a Thermolabile Variant of Human Triosephosphate Isomerase. Available at SSRN: https://ssrn.com/abstract=4848610 or http://dx.doi.org/10.2139/ssrn.4848610 http://hdl.handle.net/11086/552351 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610 http://dx.doi.org/10.2139/ssrn.4848610 spa Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ SSRN - Elsevier
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Español
topic Triosephosphate isomerase deficiency
X-ray crystallization
Stability
Flexibility
spellingShingle Triosephosphate isomerase deficiency
X-ray crystallization
Stability
Flexibility
Romero, Jorge Miguel
Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
topic_facet Triosephosphate isomerase deficiency
X-ray crystallization
Stability
Flexibility
description This is a preprint article, it offers immediate access but has not been peer reviewed. All content on this site: Copyright © 2023 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply.
format publishedVersion
article
author Romero, Jorge Miguel
author_facet Romero, Jorge Miguel
author_sort Romero, Jorge Miguel
title Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
title_short Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
title_full Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
title_fullStr Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
title_full_unstemmed Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase
title_sort structural analysis of the tpi-manchester, a thermolabile variant of human triosephosphate isomerase
publisher SSRN - Elsevier
publishDate 2024
url http://hdl.handle.net/11086/552351
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4848610
http://dx.doi.org/10.2139/ssrn.4848610
work_keys_str_mv AT romerojorgemiguel structuralanalysisofthetpimanchesterathermolabilevariantofhumantriosephosphateisomerase
_version_ 1806948978166595584

Ejemplares similares