Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
9 p.
| Autores principales: | , , , , , , , , |
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| Formato: | publishedVersion article |
| Lenguaje: | Inglés |
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2023
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| Acceso en línea: | http://hdl.handle.net/11086/550191 |
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I10-R141-11086-550191 |
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dspace |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-141 |
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Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Perinatal development Neurobehavior Reproductive function Subflower oil Fish oil |
| spellingShingle |
Perinatal development Neurobehavior Reproductive function Subflower oil Fish oil Bianconi, Santiago Santillán, María Emilia Solís, María del Rosario Martini, Ana Carolina Ponzio, Marina Flavia Vicenti, Laura María Carlini, Valeria Paola Stutz, Graciela Schiöth, Helgi B. Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| topic_facet |
Perinatal development Neurobehavior Reproductive function Subflower oil Fish oil |
| description |
9 p. |
| author2 |
https://orcid.org/0000-0001-7656-7212 |
| author_facet |
https://orcid.org/0000-0001-7656-7212 Bianconi, Santiago Santillán, María Emilia Solís, María del Rosario Martini, Ana Carolina Ponzio, Marina Flavia Vicenti, Laura María Carlini, Valeria Paola Stutz, Graciela Schiöth, Helgi B. |
| format |
publishedVersion article |
| author |
Bianconi, Santiago Santillán, María Emilia Solís, María del Rosario Martini, Ana Carolina Ponzio, Marina Flavia Vicenti, Laura María Carlini, Valeria Paola Stutz, Graciela Schiöth, Helgi B. |
| author_sort |
Bianconi, Santiago |
| title |
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| title_short |
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| title_full |
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| title_fullStr |
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| title_full_unstemmed |
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model |
| title_sort |
effects of dietary omega-3 pufas on growth and development: somatic, neurobiological and reproductive functions in a murine model |
| publishDate |
2023 |
| url |
http://hdl.handle.net/11086/550191 |
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1806948508894232576 |
| spelling |
I10-R141-11086-5501912023-12-14T11:26:19Z Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model Bianconi, Santiago Santillán, María Emilia Solís, María del Rosario Martini, Ana Carolina Ponzio, Marina Flavia Vicenti, Laura María Carlini, Valeria Paola Stutz, Graciela Schiöth, Helgi B. https://orcid.org/0000-0001-7656-7212 https://orcid.org/0000-0001-7414-3942 https://orcid.org/0000-0002-3549-2063 https://orcid.org/0000-0002-4742-2986 https://orcid.org/0000-0002-1116-1497 Perinatal development Neurobehavior Reproductive function Subflower oil Fish oil 9 p. info:eu-repo/semantics/publishedVersion Fil: Bianconi, Santiago. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Santillán, María Emilia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Solís, María del Rosario. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Ponzio, Marina Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Vicenti, Laura María. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Schiöth, Helgi B. Uppsala University. Department of Neuroscience. Functional Pharmacology; Suecia. Fil: Bianconi, Santiago. Uppsala University. Departament of Neuroscience. Functional Pharmacology; Suecia. Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Carlini, Valeria Paola. Uppsala University. Departament of Neuroscience. Functional Pharmacology; Suecia. Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P<.05). On PND14, the percentage of pups with eye opening in Excess group was lower than those from Control and Deficient groups (P<.05). In Excess female offspring, puberty onset (vaginal opening and first estrus) occurred significantly later and the percentage of parthenogenetic oocytes on PND63 was higher than Control and Deficient ones (P<.05). Deficient pups were shorter in length (males: on PND14, 21, 35 and 49; females: on PND14, 21 and 42) compared with Control pups (P<.05). Deficient offspring exhibited higher percentage of bending spermatozoa compared to Control and Excess offspring (P<.05). These results show that either an excessively high or insufficient ω-3 PUFA consumption prior to conception until adulthood seems inadvisable because of the potential risks of short-term adverse effects on growth and development of the progeny or long-lasting effects on their reproductive maturation and function. info:eu-repo/semantics/publishedVersion Fil: Bianconi, Santiago. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Santillán, María Emilia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Solís, María del Rosario. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Ponzio, Marina Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Vicenti, Laura María. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Fil: Schiöth, Helgi B. Uppsala University. Department of Neuroscience. Functional Pharmacology; Suecia. Fil: Bianconi, Santiago. Uppsala University. Departament of Neuroscience. Functional Pharmacology; Suecia. Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina Fil: Carlini, Valeria Paola. Uppsala University. Departament of Neuroscience. Functional Pharmacology; Suecia. Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto y Cátedra de Fisiología Humana; Argentina. Otras Ciencias de la Salud 2023-12-13T21:18:17Z 2023-12-13T21:18:17Z 2018 article Bianconi, Santiago; Santillan, Maria Emilia; Solís, María del Rosario; Martini, Ana Carolina; Ponzio, Marina Flavia; et al.; Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model; Elsevier Science Inc; Journal Of Nutritional Biochemistry; 61; 11-2018; 82-90 0955-2863 http://hdl.handle.net/11086/550191 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |