Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)

7 p.

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Autores principales: Stroppa, María Mercedes, Giménez, Ignacio, García, Beatriz A.
Formato: publishedVersion article
Lenguaje:Inglés
Publicado: American Society of Tropical Medicine and Hygiene 2023
Materias:
Chagas Disease
Triatoma Infestans
Clock gene period
Acceso en línea:http://hdl.handle.net/11086/550116
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
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spelling I10-R141-11086-5501162023-12-06T11:35:54Z Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae) Stroppa, María Mercedes Giménez, Ignacio García, Beatriz A. Chagas Disease Triatoma Infestans Clock gene period 7 p. info:eu-repo/semantics/publishedVersion Fil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Giménez, Ignacio. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. To contribute to a better understanding of the molecular bases of the circadian biological rhythms in Chagas disease vectors, in this work we identified functional domains in the sequences of the clock protein PERIOD in Rhodnius prolixus and Triatoma infestans and analyzed the expression of the period gene at mRNA level in T. infestans. The PERIOD protein sequences comparison among these species and those from other insects revealed that the most similar regions are the PAS domains and the most variable is the COOH-terminal. On the other hand, the per gene expression in nervous tissue of adults T. infestans varies with a daily canonical rhythm in groups of individuals maintained under photoperiod (LD) and constant dark (DD), showing a significant peak of expression at sunset. The pattern of expression detected in LD persists under the DD condition. As expected, in the group maintained in constant light (LL), no daily increase was detected in per transcript level. Besides, the presence of per transcript in different tissues of adult individuals and in nervous tissue of nymphs evidenced activity of peripheral clocks in adults and activity of the central clock in nymphs of T. infestans. info:eu-repo/semantics/publishedVersion Fil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Fil: Giménez, Ignacio. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. Bioquímica y Biología Molecular (ídem 3.1.10) 2023-12-05T21:24:57Z 2023-12-05T21:24:57Z 2018 article 0002-9637 http://hdl.handle.net/11086/550116 1476-1645 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso American Society of Tropical Medicine and Hygiene
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Chagas Disease
Triatoma Infestans
Clock gene period
spellingShingle Chagas Disease
Triatoma Infestans
Clock gene period
Stroppa, María Mercedes
Giménez, Ignacio
García, Beatriz A.
Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
topic_facet Chagas Disease
Triatoma Infestans
Clock gene period
description 7 p.
format publishedVersion
article
author Stroppa, María Mercedes
Giménez, Ignacio
García, Beatriz A.
author_facet Stroppa, María Mercedes
Giménez, Ignacio
García, Beatriz A.
author_sort Stroppa, María Mercedes
title Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
title_short Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
title_full Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
title_fullStr Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
title_full_unstemmed Clock gene period in the Chagas disease vector Triatoma infestans (Hemiptera: Reduviidae)
title_sort clock gene period in the chagas disease vector triatoma infestans (hemiptera: reduviidae)
publisher American Society of Tropical Medicine and Hygiene
publishDate 2023
url http://hdl.handle.net/11086/550116
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AT gimenezignacio clockgeneperiodinthechagasdiseasevectortriatomainfestanshemipterareduviidae
AT garciabeatriza clockgeneperiodinthechagasdiseasevectortriatomainfestanshemipterareduviidae
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