Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine

Fil: Trujillo, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.

Guardado en:
Detalles Bibliográficos
Autores principales: Trujillo, Verónica, Rivarola, Angélica, Suárez, Marta
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2023
Materias:
Hipocampo
Hipotálamo
Amígdala
Tianeptina
Acceso en línea:http://hdl.handle.net/11086/549914
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-549914
record_format dspace
spelling I10-R141-11086-5499142023-11-18T06:21:05Z Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine Trujillo, Verónica Rivarola, Angélica Suárez, Marta Hipocampo Hipotálamo Amígdala Tianeptina Fil: Trujillo, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Rivarola, Angélica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Suárez, Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Hippocampus, amygdala and paraventricular nucleus of hypothalamus (PVN), which belong to the reward system, widely express Gluco- and mineralo- corticoid receptors (GR and MR, respectively) and are critically involved in the regulation of stress response. It has been well established that stress both during early life as well as in adulthood, increases the susceptibility of developing depression. The aim of this work was to determine the effect of chronic treatment with 10 mg/Kg of tianeptine on GR and MR expression in the layers CA1, CA2, CA3 and dentate gyrus (DG) of dorsal hippocampus, medial amygdala and PVN, in male Wistar rats submitted to early maternal separation and variable chronic stress as adults (a model of depression). GR and MR levels were determined by immunohistochemistry. In hippocampus and amygdala, we found that in non-maternally separated (NMS) groups, animals subjected to stress showed more GR immunoreactive (GR-ir) cells, whereas in maternally separated (NS) groups, stress decreased the number of these neurons, showing similar levels to control group (p<0,05). Furthermore, there was a similar effect in the MR immunoreactivity (MR-ir) (p<0,05) in the layers CA2 and DG of the hippocampus. Besides, in the layers CA1 and CA2, we found less GR-ir and MR-ir neurons in MS-stressed compared with NMS-stressed group (p<0,05). In MS-stressed animals, daily administration of the antidepressant tianeptine increased GR-ir in hippocampus and amygdala and MR-ir in DG of hippocampus and PVN (p<0,05). In conclusion, stressed animals show a differential regulation of GR and MR levels in dorsal hippocampus, PVN and medial amygdala, according with early life events. Whereas tianeptine increased GR-ir and MR-ir in MS-stressed animals, which might attenuate the upsetting of hypothalamic-pituitary-adrenal axis. http://dx.doi.org/10.1016/j.ijdevneu.2015.04.204 Fil: Trujillo, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Rivarola, Angélica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Suárez, Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Bioquímica y Biología Molecular (ídem 3.1.10) 2023-11-17T11:56:29Z 2023-11-17T11:56:29Z 2014 conferenceObject http://hdl.handle.net/11086/549914 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso; Electrónico y/o Digital
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Hipocampo
Hipotálamo
Amígdala
Tianeptina
spellingShingle Hipocampo
Hipotálamo
Amígdala
Tianeptina
Trujillo, Verónica
Rivarola, Angélica
Suárez, Marta
Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
topic_facet Hipocampo
Hipotálamo
Amígdala
Tianeptina
description Fil: Trujillo, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
format conferenceObject
author Trujillo, Verónica
Rivarola, Angélica
Suárez, Marta
author_facet Trujillo, Verónica
Rivarola, Angélica
Suárez, Marta
author_sort Trujillo, Verónica
title Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
title_short Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
title_full Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
title_fullStr Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
title_full_unstemmed Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
title_sort corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: effects of tianeptine
publishDate 2023
url http://hdl.handle.net/11086/549914
work_keys_str_mv AT trujilloveronica corticosteroidreceptorimmunoreactivityinneuronsofthehippocampusamygdalaandparaventricularnucleusinratsundermaternalseparationandchronicstresseffectsoftianeptine
AT rivarolaangelica corticosteroidreceptorimmunoreactivityinneuronsofthehippocampusamygdalaandparaventricularnucleusinratsundermaternalseparationandchronicstresseffectsoftianeptine
AT suarezmarta corticosteroidreceptorimmunoreactivityinneuronsofthehippocampusamygdalaandparaventricularnucleusinratsundermaternalseparationandchronicstresseffectsoftianeptine
_version_ 1806949685717368832

Ejemplares similares