Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair

Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.

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Detalles Bibliográficos
Autores principales:	Romanazzi Chumbita, Lucas, Reati, Carolina, Interlandi, Victoria, Fontanetti, Pablo Alejandro, Centeno, Viviana Andrea
Formato:	conferenceObject
Lenguaje:	Inglés
Publicado:	2023
Materias:	Sodiun monofluorphosphate Dental extraction Bone repair
Acceso en línea:	http://hdl.handle.net/11086/548378
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R141-11086-548378
record_format	dspace
spelling	I10-R141-11086-5483782023-08-31T18:10:14Z Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair Romanazzi Chumbita, Lucas Reati, Carolina Interlandi, Victoria Fontanetti, Pablo Alejandro Centeno, Viviana Andrea Sodiun monofluorphosphate Dental extraction Bone repair Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina. Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. The most used drugs as sources of fluoride (F-) in human therapeutics are sodium fluoride (NaF) and sodic monofluorphosphate (Na2FPO ? MFP). Fluoride bioavailability is greater when MFP is administrated, which allows to use lower doses to decrease adverse effects. According to the dose and the administration form, this ion produces different biologic and physical-chemical effects on bone tissue. OBJECTIVE: To study the effect triggered by chronic exposure to MFP during the active phase of bone resorption post-dental extraction, on the structural properties of alveolar bone and metabolic parameters associated. METHODS: Male Wistar rats (n=4-6 per group) to which it was extracted the first molar from one of the hemimandible, were divided into two experimental groups who drank water with different F- concentrations during 4 weeks: Controls (0,016 mM of F-) and Treated with MFP (0,4 mM of F-). Biochemical parameters of phosphocalcic metabolism were analyzed in plasma samples. Urinary F- was determined using an ion selective electrode. Complete jaws were extracted, histologically processed and stained with H&E. On digital microphotographs of serial buccolingual sections, at the level of first molar, the percentage of bone formed [BV/TV (%)], in the alveolar cavity during post-extraction period was measured using Image Pro Plus software. Results were analyzed by Student ?t? test and were expressed as media ± SE. RESULTS: No significant differences were observed in water intake nor body weight gain due to treatment. Urinary F- was higher in rats chronically exposed to MFP (p<0,05). Calcemia and phosphatemia were increased in treated animals (p<0,05) and total alkaline phosphatase (FAL) did not showed significant differences between groups. BV/TV (%) in alveolar cavity was lower in treated animals compared to controls (p<0,05). CONCLUSION: Fluoride incorporation in the form of MFP during the immediate post-dental extraction period produced an alteration in phosphocalcic metabolism and a decrease of alveolar bone volume, suggesting a negative effect on the dental bone repair process. Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina. Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina. Otras Ciencias de la Salud 2023-08-07T14:51:20Z 2023-08-07T14:51:20Z 2016 conferenceObject http://hdl.handle.net/11086/548378 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Sodiun monofluorphosphate Dental extraction Bone repair
spellingShingle	Sodiun monofluorphosphate Dental extraction Bone repair Romanazzi Chumbita, Lucas Reati, Carolina Interlandi, Victoria Fontanetti, Pablo Alejandro Centeno, Viviana Andrea Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
topic_facet	Sodiun monofluorphosphate Dental extraction Bone repair
description	Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
format	conferenceObject
author	Romanazzi Chumbita, Lucas Reati, Carolina Interlandi, Victoria Fontanetti, Pablo Alejandro Centeno, Viviana Andrea
author_facet	Romanazzi Chumbita, Lucas Reati, Carolina Interlandi, Victoria Fontanetti, Pablo Alejandro Centeno, Viviana Andrea
author_sort	Romanazzi Chumbita, Lucas
title	Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
title_short	Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
title_full	Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
title_fullStr	Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
title_full_unstemmed	Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
title_sort	chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair
publishDate	2023
url	http://hdl.handle.net/11086/548378
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Chronic exposure to sodium monofluorphosphate post-dental extraction decreases alveolar bone repair

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