Analysis of factors and mechanisms that control growth in the genital disc of drosophila

Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina.

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Detalles Bibliográficos
Autores principales: Arias, Carolina, Fussero, Gimena, Zacharonok, Marcelo
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2023
Materias:
Drosófila
Células
Dpp/Wg
JNK
Acceso en línea:http://hdl.handle.net/11086/547664
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-547664
record_format dspace
spelling I10-R141-11086-5476642023-08-30T13:57:10Z Analysis of factors and mechanisms that control growth in the genital disc of drosophila Arias, Carolina Fussero, Gimena Zacharonok, Marcelo Drosófila Células Dpp/Wg JNK Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Arias, Carolina. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. The relation among proliferation and death duringgrowth is explained by the competition mechanism. This sees, the cells growth,in relation with their neighbors; if the rhythms of growth are notcoincidental, the lower growing cells are removed by apoptosis.There is aspecial type of cell competition called morphogenetic apoptosis.This occurs ifdiscontinuities in the growth /surviving signals Dpp/Wg are induced.Under thesecircumstances death mediated by the JNK mechanism is observed at the borders ofthe discontinuities. A tissue-physiologycal scenario for such discontinuitiescould be the time/place when Dpp and Wg expressions start. The differences inthe amount among, expressing and non expressing cells should be high at the beginningbut should decreased as development progress. In accordance, morphogeneticapoptosis must occurs at the borders of Dpp/Wg expressions. We tested this ideain the genital disc of Drosophilawhere the activation of Dpp occurs late in development, there is a celldivision arrest up to that time, and death plays roles. We center our analysisin the activities of Dpp, JNK, the pro-apoptotic genes RGH and the enzymes caspases.Our main results indicated there is cell competition/morphogenetic apoptosis atthe borders of Dpp expression, revealed principally not by the death but forits compensatory proliferation. The net balance among death/proliferationappeared cero, so physiologycal cell competition does not vary the size. Thelevels of active JNK and caspases are important for: the execution of death,the control of proliferation, and the occurrence of compensatory proliferation.TheJNK/capases activity over proliferation determines them as factors of cellcompetition. Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Arias, Carolina. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Biología del Desarrollo 2023-06-06T14:18:34Z 2023-06-06T14:18:34Z 2013 conferenceObject http://hdl.handle.net/11086/547664 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Drosófila
Células
Dpp/Wg
JNK
spellingShingle Drosófila
Células
Dpp/Wg
JNK
Arias, Carolina
Fussero, Gimena
Zacharonok, Marcelo
Analysis of factors and mechanisms that control growth in the genital disc of drosophila
topic_facet Drosófila
Células
Dpp/Wg
JNK
description Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina.
format conferenceObject
author Arias, Carolina
Fussero, Gimena
Zacharonok, Marcelo
author_facet Arias, Carolina
Fussero, Gimena
Zacharonok, Marcelo
author_sort Arias, Carolina
title Analysis of factors and mechanisms that control growth in the genital disc of drosophila
title_short Analysis of factors and mechanisms that control growth in the genital disc of drosophila
title_full Analysis of factors and mechanisms that control growth in the genital disc of drosophila
title_fullStr Analysis of factors and mechanisms that control growth in the genital disc of drosophila
title_full_unstemmed Analysis of factors and mechanisms that control growth in the genital disc of drosophila
title_sort analysis of factors and mechanisms that control growth in the genital disc of drosophila
publishDate 2023
url http://hdl.handle.net/11086/547664
work_keys_str_mv AT ariascarolina analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila
AT fusserogimena analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila
AT zacharonokmarcelo analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila
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