Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function

Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.

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Autor principal: Kembro, Jackelyn Melissa
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2023
Materias:
Química biológica
Redes mitocondriales
Reactive oxygen species [ROS]
Investigaciones biológicas
Acceso en línea:http://hdl.handle.net/11086/547217
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-547217
record_format dspace
spelling I10-R141-11086-5472172024-02-29T06:23:24Z Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function Kembro, Jackelyn Melissa Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Biofísica 2023-04-27T13:00:32Z 2023-04-27T13:00:32Z 2014 conferenceObject http://hdl.handle.net/11086/547217 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Química biológica
Redes mitocondriales
Reactive oxygen species [ROS]
Investigaciones biológicas
spellingShingle Química biológica
Redes mitocondriales
Reactive oxygen species [ROS]
Investigaciones biológicas
Kembro, Jackelyn Melissa
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
topic_facet Química biológica
Redes mitocondriales
Reactive oxygen species [ROS]
Investigaciones biológicas
description Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
format conferenceObject
author Kembro, Jackelyn Melissa
author_facet Kembro, Jackelyn Melissa
author_sort Kembro, Jackelyn Melissa
title Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
title_short Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
title_full Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
title_fullStr Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
title_full_unstemmed Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
title_sort complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
publishDate 2023
url http://hdl.handle.net/11086/547217
work_keys_str_mv AT kembrojackelynmelissa complexoscillatoryredoxdynamicswithsignalingpotentialattheedgebetweennormalandpathologicalmitochondrialfunction
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