Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.

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Creatine (Cr) plays an important role in storage and transmission of phosphate-bound energy. Cerebral creatine deficiency syndromes comprise three inherited defects in Cr biosynthesis and transport. The aim of this study was to investigate whether Cr and Guanidinoacetate (GAA) can be detected in sa...

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Autores principales: Martínez, L.D., Bezard, M., Brunotto, M., Dodelson de Kremer, R.
Formato: article
Lenguaje:Inglés
Publicado: Acta Odontológica Latinoamericana : AOL. 2017
Materias:
Creatine deficiency
Biomarkers
Saliva
Brain
Chromatography, Gas
Acceso en línea:http://hdl.handle.net/11086/4888
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-4888
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Creatine deficiency
Biomarkers
Saliva
Brain
Chromatography, Gas
spellingShingle Creatine deficiency
Biomarkers
Saliva
Brain
Chromatography, Gas
Martínez, L.D.
Bezard, M.
Brunotto, M.
Dodelson de Kremer, R.
Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
topic_facet Creatine deficiency
Biomarkers
Saliva
Brain
Chromatography, Gas
description Creatine (Cr) plays an important role in storage and transmission of phosphate-bound energy. Cerebral creatine deficiency syndromes comprise three inherited defects in Cr biosynthesis and transport. The aim of this study was to investigate whether Cr and Guanidinoacetate (GAA) can be detected in saliva of healthy subjects and to establish the relationship between salivary and plasma levels of these molecules. An adapted gas chromatography (GC) method is described for the quantification of Cr and GAA biomarkers in saliva. Reference values were established for GAA and Cr in saliva. These values were age dependent (p= 0.001). No difference between genders was observed. We detected a difference between GAA and Cr concentrations in saliva and in plasma. The GC method for simultaneous determination of GAA and Cr in human saliva is fast, reliable, sensitive, non-invasive and precise to use as a biochemical approach in early detection of cerebral creatine deficiency syndromes.
format article
author Martínez, L.D.
Bezard, M.
Brunotto, M.
Dodelson de Kremer, R.
author_facet Martínez, L.D.
Bezard, M.
Brunotto, M.
Dodelson de Kremer, R.
author_sort Martínez, L.D.
title Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
title_short Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
title_full Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
title_fullStr Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
title_full_unstemmed Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
title_sort creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
publisher Acta Odontológica Latinoamericana : AOL.
publishDate 2017
url http://hdl.handle.net/11086/4888
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