Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin

In this work, complexes of β-cyclodextrin and the two solid forms of furosemide were prepared and characterized for their potential pharmaceutical applications, with the interactions between the two compounds being studied in the solution and solid states. The solubility studies revealed different b...

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Detalles Bibliográficos
Autores principales: Garnero, Claudia, Chattah, Ana Karina, Longhi, Marcela Raquel
Formato: article
Lenguaje:Inglés
Publicado: 2022
Materias:
Furosemide
β-ciclodextrin
Beta-cyclodextrin
Complexation
Polymorphism
Ssnmr
Acceso en línea:http://hdl.handle.net/11086/28061
http://dx.doi.org/10.1016/j.jpba.2014.02.017
http://dx.doi.org/10.1016/j.jpba.2014.02.017
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-28061
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Furosemide
β-ciclodextrin
Beta-cyclodextrin
Complexation
Polymorphism
Ssnmr
spellingShingle Furosemide
β-ciclodextrin
Beta-cyclodextrin
Complexation
Polymorphism
Ssnmr
Garnero, Claudia
Chattah, Ana Karina
Longhi, Marcela Raquel
Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
topic_facet Furosemide
β-ciclodextrin
Beta-cyclodextrin
Complexation
Polymorphism
Ssnmr
description In this work, complexes of β-cyclodextrin and the two solid forms of furosemide were prepared and characterized for their potential pharmaceutical applications, with the interactions between the two compounds being studied in the solution and solid states. The solubility studies revealed different behaviors of the polymorphs. In particular, it was observed that the binary complex significantly increased the solubility of furosemide form I in the gastric simulated fluid, which resulted in a rise in the bioavailability of this formulation after oral administration. In addition, results using ssNMR, FT-IR, DSC, TGA, SEM and XRPD provided evidence of the formation of complexes after utilizing kneading and freeze-drying methods. A comparison with previous developed complexes that used maltodextrin as the ligand was performed. Our results suggest that these novel supramolecular complexes showed promise to be used in drug delivery systems with an application in pharmaceutical formulations.
format article
author Garnero, Claudia
Chattah, Ana Karina
Longhi, Marcela Raquel
author_facet Garnero, Claudia
Chattah, Ana Karina
Longhi, Marcela Raquel
author_sort Garnero, Claudia
title Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
title_short Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
title_full Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
title_fullStr Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
title_full_unstemmed Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
title_sort improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
publishDate 2022
url http://hdl.handle.net/11086/28061
http://dx.doi.org/10.1016/j.jpba.2014.02.017
http://dx.doi.org/10.1016/j.jpba.2014.02.017
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